Reactome | Inhibition of Host mRNA Processing and RNA Silencing

Inhibition of Host mRNA Processing and RNA Silencing

Stable Identifier

R-HSA-168315

Type

Pathway

Species

Homo sapiens

Related Species

Influenza A virus

ReviewStatus

5/5

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Inhibition of Host mRNA Processing and RNA Silencing

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The Influenza Virus NS1 protein inhibits the cleavage and polyadenylation specificity factor CPSF and the PABII components of the host cell 3' end processing machinery, preventing efficient 3' end processing of host pre-mRNAs. NS1 also inhibits the splicing of pre-mRNAs, resulting in their retention within the host cell nucleus.

Literature References

PubMed ID	Title	Journal	Year
10205180	Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery Chen, Z, Krug, RM, Li, Y	EMBO J	1999
7958859	The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing Lu, Y, Krug, RM, Qian, XY	Genes Dev	1994
8313914	Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport Beloso, A, Ortin, J, Fortes, P	EMBO J	1994

Participants

Events

Participates

as an event of

NS1 Mediated Effects on Host Pathways (Homo sapiens)

Event Information

Go Biological Process

suppression by virus of host mRNA processing (0039524)

Disease

Name	Identifier	Synonyms
influenza	DOID:8469	Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation

Authored

Gillespie, ME (2013-11-18)

Reviewed

Gale M, Jr (2004-05-12)

Created

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