Reactome | p-S172-TBK1 [cytosol]

p-S172-TBK1 [cytosol]

Stable Identifier

R-HSA-168379

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        TBK1 binds amlexanox (Homo sapiens)
        
        TBK1:amlexanox [cytosol] (Homo sapiens)
        
        dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
        
        dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
        
        p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
        
        p-S172-TBK1:p-S172-TBK1 [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Death Receptor Signaling (Homo sapiens)
  - TNF signaling (Homo sapiens)
    - Regulation of TNFR1 signaling (Homo sapiens)
      - TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Homo sapiens)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
        
        p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
        
        p-S172-TBK1:p-S172-TBK1 [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
      - TBK1, IKBKE phosphorylate RIPK1 at T189 (Homo sapiens)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
        
        p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
        
        p-S172-TBK1:p-S172-TBK1 [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
        
        TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
        
        p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
        
        p-S172-TBK1:p-S172-TBK1 [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
        
        p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
        
        p-S172-TBK1:p-S172-TBK1 [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
    - TNFR1-induced proapoptotic signaling (Homo sapiens)
      - TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Homo sapiens)
        
        TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
        
        p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
        
        p-S172-TBK1:p-S172-TBK1 [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)
        
        p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
        
        p-S172-TBK1:p-S172-TBK1 [cytosol] (Homo sapiens)
        
        p-S172-TBK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UHD2 TBK1

Gene Names

TBK1, NAK

Chain

chain:1-729

Reference Genes

BioGPS Gene:29110 TBK1

COSMIC (genes):TBK1 TBK1

CTD Gene:29110 TBK1

dbSNP Gene:29110 TBK1

ENSEMBL:ENSG00000183735 TBK1

ENSEMBL:ENSG00000183735.11 TBK1

HGNC:11584 TBK1

KEGG Gene (Homo sapiens):29110 TBK1

Monarch:29110 TBK1

NCBI Gene:29110 TBK1

OMIM:604834 TBK1

UCSC:Q9UHD2 TBK1

Reference Transcript

Other Identifiers

11717931_at

11717932_at

16753498

218520_PM_at

218520_at

29110

3419850

3419853

3419854

3419855

3419856

3419858

3419861

3419865

3419866

3419867

3419870

3419871

3419872

3419873

3419874

3419875

3419877

3419879

3419881

3419882

3419883

3419884

3419885

3419887

3419889

3419890

3419891

63819_at

7956795

A_14_P113016

A_23_P44768

GO:0000166

GO:0002218

GO:0002376

GO:0002753

GO:0003676

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006468

GO:0006914

GO:0006954

GO:0007249

GO:0009615

GO:0010468

GO:0010508

GO:0010629

GO:0010803

GO:0016239

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018107

GO:0019903

GO:0023052

GO:0032479

GO:0032481

GO:0032727

GO:0032728

GO:0033138

GO:0036211

GO:0042802

GO:0043123

GO:0043226

GO:0043231

GO:0044565

GO:0045087

GO:0045944

GO:0050830

GO:0051219

GO:0051607

GO:0060337

GO:0060340

GO:0098542

GO:0098772

GO:0106310

GO:0140096

GO:0140374

GO:0140677

GO:1901214

GO:1902554

GO:1904417

HMNXSV003037647

ILMN_1739967

PH_hs_0025240

TC12000570.hg

g7019546_3p_at

Participates

as a component of

Other forms of this molecule

pS-172,K48polyUb-TBK1 [cytosol]

p-TBK1 [cytosol]

TBK1 [cytosol]

Inferred To

phospho-TBK1 [cytosol] (Gallus gallus)

phospho-TBK1 [cytosol] (Sus scrofa)

p-S172-Tbk1 [cytosol] (Mus musculus)

phospho-p-S172-TBK1 [cytosol] (Bos taurus)

phospho-p-S172-TBK1 [cytosol] (Canis familiaris)

phospho-p-S172-TBK1 [cytosol] (Danio rerio)

phospho-p-S172-TBK1 [cytosol] (Drosophila melanogaster)

phospho-p-S172-TBK1 [cytosol] (Xenopus tropicalis)

phospho-Tbk1 [cytosol] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-serine at 172

Coordinate

172

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_005268867.1, NP_037386.1, XP_005268866.1

ZINC - World Drugs

TBK1_HUMAN

Guide to Pharmacology - Targets

2237

OpenTargets

ENSG00000183735

ZINC - FDA approved

TBK1_HUMAN

ZINC - Substances

TBK1_HUMAN

ZINC - Biogenic

TBK1_HUMAN

ZINC target

Q9UHD2

PRO

Q9UHD2

PDB

6NT9, 5EOA, 6BOD, 6CQ4, 5EOF, 6BOE, 6CQ5, 6RSR, 4EFO, 4IWO, 5W5V, 6RST, 4IWP, 6RSU, 5EP6, 4IM0, 4IWQ, 4EUT, 4IM2, 4IW0, 6O8B, 6BNY, 4IM3, 6CQ0, 4EUU

ZINC - Investigational

TBK1_HUMAN

HPA

ENSG00000183735-TBK1

GeneCards

Q9UHD2

Ensembl

ENSG00000183735, ENSP00000329967, ENST00000331710, ENST00000650790, ENSP00000498995

Pharos - Targets

Q9UHD2

Orphanet

21615

ZINC - Predictions - Purchasable

TBK1_HUMAN

Interactors (46)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92844 TANK	2	TANK [cytosol] (R-HSA-933407) K63polyUb-TANK [cytosol] (R-HSA-5362480)	0.924	14
UniProt:Q14653 IRF3	6	p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) IRF3(272-427) [cytosol] (R-HSA-9729737) IRF3(2-271) [cytosol] (R-HSA-9729696) IRF3 [cytosol] (R-HSA-166251)	0.92	10
UniProt:Q86WV6 STING1	5	TMEM173 [plasma membrane] (R-HSA-6804815) TMEM173 [secretory granule membrane] (R-HSA-6804798) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) STING [endoplasmic reticulum membrane] (R-HSA-1834940)	0.899	9
UniProt:Q96CV9 OPTN	5	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907)	0.898	16
UniProt:A7MCY6 TBKB1			0.858	9
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.857	7
UniProt:P0DTD1-PRO_0000449630 REP			0.822	6
UniProt:Q9H6S1 AZI2			0.813	7
UniProt:Q13137 CACO2			0.748	7
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.723	6
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.708	6
UniProt:P59596 M	10	M [plasma membrane] (R-COV-9731038) M [Golgi membrane] (R-COV-9683651) N-glycan M [endoplasmic reticulum membrane] (R-COV-9683588) nascent M [endoplasmic reticulum lumen] (R-COV-9683586) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684206) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684213) M [endocytic vesicle membrane] (R-COV-9686687) N-glycan M [endocytic vesicle membrane] (R-COV-9686698) M [virion membrane] (R-COV-9678151) N-glycan M [virion membrane] (R-COV-9685474)	0.702	5
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.702	4
UniProt:Q13114 TRAF3	4	TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.688	4
UniProt:Q8IUC6 TICAM1	4	TICAM1 S186L [cytosol] (R-HSA-5607964) TICAM1 R141* [cytosol] (R-HSA-5602690) TICAM1 [cytosol] (R-HSA-166170) TICAM1 [endosome membrane] (R-HSA-450316)	0.688	3
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.681	10
UniProt:Q14164 IKBKE	4	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.669	5
UniProt:Q6DT37 MRCKG			0.623	3
UniProt:Q9UHD2 TBK1	4	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267)	0.609	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.589	3
UniProt:Q60803	3	Traf3 [cytosol] (R-MMU-936556) Traf3 [cytosol] (R-MMU-914241) Traf3 [cytosol] (R-MMU-936402)	0.589	2
UniProt:P42226 STAT6	6	p-S407,Y641-STAT6 [nucleoplasm] (R-HSA-3261241) p-S407,Y641-STAT6 [cytosol] (R-HSA-3249376) p-S407-STAT6 [cytosol] (R-HSA-3249369) STAT6 [cytosol] (R-HSA-629625) p-Y641-STAT6 [nucleoplasm] (R-HSA-6786279) p-Y641-STAT6 [cytosol] (R-HSA-6786109)	0.577	7
UniProt:P27958-PRO_0000037573			0.571	4
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.564	2
UniProt:W5VXH5 W5VXH5			0.556	3
UniProt:O75558 STX11			0.547	2
UniProt:Q9H492 MAP1LC3A	3	MAP1LC3A [autophagosome membrane] (R-HSA-5683640) MAP1LC3A(1-121) [cytosol] (R-HSA-5682681) MAP1LC3A [cytosol] (R-HSA-5205676)	0.544	2
UniProt:Q05127 VP35			0.544	2
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.544	2
UniProt:O95801 TTC4			0.537	5
UniProt:I6W9F2 I6W9F2			0.537	6
UniProt:P27958-PRO_0000037572			0.524	2
UniProt:K7Y1A2 K7Y1A2			0.524	2
UniProt:Q92985 IRF7	5	K63polyUb-IRF7 [endosome membrane] (R-HSA-975154) IRF7 [endosome membrane] (R-HSA-450274) p-S477,S479-IRF7 [nucleoplasm] (R-HSA-450270) p-S477,S479-IRF7 [cytosol] (R-HSA-450318) IRF7 [cytosol] (R-HSA-450281)	0.508	2
UniProt:CYorf15B CY15B			0.499	2
UniProt:Q9Y6W8 ICOS			0.499	5
UniProt:Q9NVV4 PAPD1			0.499	2
UniProt:Q86YT6 MIB1	1	MIB1 [cytosol] (R-HSA-1472877)	0.499	2
UniProt:Q7Z3C6 ATG9A	1	ATG9A [phagophore assembly site membrane] (R-HSA-5671732)	0.499	2
UniProt:Q8BHN1 TXLNG			0.499	2
UniProt:O14730 RIOK3	1	RIOK3 [cytosol] (R-HSA-6791522)	0.499	3
UniProt:Q96AX9 MIB2	1	MIB2 [cytosol] (R-HSA-1472879)	0.499	2
UniProt:Q9UKV8 AGO2	2	AGO2 [nucleoplasm] (R-HSA-5578701) AGO2 [cytosol] (R-HSA-209723)	0.499	2
UniProt:O41932 O41932			0.488	4
UniProt:A0A0B5AC19 NSS			0.463	4
UniProt:P0DTD2 9b	3	p-S53-9b [cytosol] (R-COV-9758478) 9b [cytosol] (R-COV-9694649) 9b [mitochondrial outer membrane] (R-COV-9709803)	0.463	2

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