Reactome | RIPK2 [cytosol]

RIPK2 [cytosol]

Stable Identifier

R-HSA-168402

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RIP2, RICK, receptor-interacting serine-threonine kinase 2

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Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ovarian tumor domain proteases (Homo sapiens)
      - TNFAIP3 (A20) deubiquitinates RIP2 (Homo sapiens)
        
        PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
        
        PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
        
        RIPK2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43353 RIPK2

Gene Names

RIPK2, RIPK2, CARDIAK, RICK, RIP2, UNQ277/PRO314/PRO34092

Chain

chain:1-540

Reference Genes

BioGPS Gene:8767 RIPK2

COSMIC (genes):RIPK2 RIPK2

CTD Gene:8767 RIPK2

dbSNP Gene:8767 RIPK2

ENSEMBL:ENSG00000104312 RIPK2

HGNC:10020 RIPK2

KEGG:hsa:8767 RIPK2

Monarch:8767 RIPK2

NCBI Gene:8767 RIPK2

OMIM:603455 RIPK2

UCSC:O43353 RIPK2

Reference Transcript

Other Identifiers

11724236_a_at

11758901_at

17070634

209544_PM_at

209544_at

209545_PM_s_at

209545_s_at

3106244

3106245

3106246

3106247

3106248

3106249

3106250

3106251

3106252

3106254

3106257

3106258

3106260

3106261

3106262

3106263

3106264

3106265

3106266

41384_at

8147206

8767

A_14_P112304

A_14_P130548

A_14_P202266

A_23_P252106

A_24_P124032

GE54827

GO:0001961

GO:0002250

GO:0002376

GO:0002827

GO:0003824

GO:0004672

GO:0004674

GO:0004706

GO:0004713

GO:0004715

GO:0005102

GO:0005515

GO:0005524

GO:0005737

GO:0005783

GO:0005829

GO:0005856

GO:0005886

GO:0006355

GO:0006468

GO:0006914

GO:0006915

GO:0006950

GO:0006954

GO:0007165

GO:0007166

GO:0007249

GO:0007254

GO:0010800

GO:0012501

GO:0016301

GO:0016740

GO:0019221

GO:0030274

GO:0031349

GO:0031398

GO:0031663

GO:0031982

GO:0032092

GO:0032722

GO:0032727

GO:0032728

GO:0032729

GO:0032731

GO:0032735

GO:0032743

GO:0032755

GO:0032760

GO:0032874

GO:0032991

GO:0033080

GO:0033092

GO:0033138

GO:0034134

GO:0034142

GO:0035591

GO:0035739

GO:0042098

GO:0042742

GO:0042802

GO:0042803

GO:0042981

GO:0043065

GO:0043123

GO:0043226

GO:0043330

GO:0045087

GO:0045627

GO:0045944

GO:0046330

GO:0050700

GO:0050731

GO:0050830

GO:0050852

GO:0051092

GO:0051260

GO:0051403

GO:0051604

GO:0060090

GO:0060907

GO:0065003

GO:0070371

GO:0070374

GO:0070427

GO:0070431

GO:0070555

GO:0070671

GO:0070673

GO:0071222

GO:0071223

GO:0071224

GO:0071225

GO:0089720

GO:0097202

GO:0098542

GO:0098792

GO:0106310

GO:0140096

GO:1902523

GO:1904417

GO:2000563

HMNXSV003009409

ILMN_1758939

PH_hs_0005753

TC08000545.hg

TC08002008.hg

g3123886_3p_at

g3123886_3p_x_at

g3290171_3p_a_at

Participates

as a component of

as an input of

Other forms of this molecule

Ub-209-RIPK2 [cytosol]

Inferred To

Homologues of RIPK2 [cytosol] (Plasmodium falciparum)

Ripk2 [cytosol] (Rattus norvegicus)

RIPK2 [cytosol] (Bos taurus)

RIPK2 [cytosol] (Caenorhabditis elegans)

RIPK2 [cytosol] (Canis familiaris)

RIPK2 [cytosol] (Danio rerio)

RIPK2 [cytosol] (Drosophila melanogaster)

RIPK2 [cytosol] (Gallus gallus)

RIPK2 [cytosol] (Mus musculus)

RIPK2 [cytosol] (Plasmodium falciparum)

RIPK2 [cytosol] (Sus scrofa)

ripk2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_003812.1, XP_005251149.1

ZINC - World Drugs

RIPK2_HUMAN

Guide to Pharmacology - Targets

2190

OpenTargets

ENSG00000104312

ENSEMBL

ENSP00000220751, ENST00000220751

ZINC - FDA approved

RIPK2_HUMAN

ZINC - Substances

RIPK2_HUMAN

ZINC - Biogenic

RIPK2_HUMAN

ZINC target

O43353

PRO

O43353

GlyGen

O43353

PDB

5J7B, 5AR8, 6S1F, 2N83, 6UL8, 6GGS, 5NG0, 5W5O, 6HMX, 7OBS, 6FU5, 5W5J, 5YRN, 6SZE, 7OBT, 5AR7, 5AR5, 6RNA, 5AR4, 6RN8, 5J79, 2N7Z, 6ES0, 6GFJ, 4C8B, 5AR3, 5AR2, 5NG3, 5NG2, 6SZJ, 8AZA

ZINC - Investigational

RIPK2_HUMAN

HPA

ENSG00000104312-RIPK2

Pharos - Targets

O43353

ZINC - Predictions - Purchasable

RIPK2_HUMAN

HMDB Protein

HMDBP01505

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.951	22
UniProt:Q9HC29 NOD2	1	NOD2 [cytosol] (R-HSA-168411)	0.8	6
UniProt:Q9Y239 NOD1	1	NOD1 [cytosol] (R-HSA-168407)	0.762	6
UniProt:O43353 RIPK2	2	Ub-209-RIPK2 [cytosol] (R-HSA-706483) RIPK2 [cytosol] (R-HSA-168402)	0.749	7
UniProt:Q13114 TRAF3	4	K63polyUb-TRAF3 [cytosol] (R-HSA-936402) TRAF3 [cytosol] (R-HSA-914241) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 R118W [cytosol] (R-HSA-5602321)	0.72	6
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.688	3
UniProt:Q13489 BIRC3	3	BIRC3 [cytosol] (R-HSA-50845) K48pUb-BIRC3 [cytosol] (R-HSA-5675478) K63polyUb-BIRC3 [cytosol] (R-HSA-5668478)	0.602	3
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.602	3
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.576	3
UniProt:Q9BVT8 TMUB1			0.527	2
UniProt:Q5VV17 OTUD1	1	OTUD1 [cytosol] (R-HSA-9816081)	0.463	3