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About
What is Reactome ?
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Team
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Our Logo
License Agreement
Privacy Notice
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Digital Preservation
Contact us
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Table of Contents
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NOD1 [cytosol]
Stable Identifier
R-HSA-168407
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Caspase recruitment domain protein 4
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
Activated NOD oligomer recruites RIP2 (RICK) (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
Activated NOD1 oligomerizes (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
CARD9 binds RIP2 (and NOD2) (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:CARD9 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
CYLD deubiquitinates NEMO (Homo sapiens)
PAMP:NOD oligomer:RIP2:K63-Ub-K285-NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
K63 polyubiquitinated RIP2 associates with the TAK1 complex (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
NOD1:iE-DAP:Long prodomain caspases [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
RIP2 binds NEMO (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
RIP2 induces K63-linked ubiquitination of NEMO (Homo sapiens)
PAMP:NOD oligomer:RIP2:K63-Ub-K285-NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
RIP2 is K63 polyubiquitinated (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
TAK1 is activated (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
TNFAIP3 (A20) deubiquitinates RIP2 (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
iE-DAP elicits a NOD1 response (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ovarian tumor domain proteases (Homo sapiens)
TNFAIP3 (A20) deubiquitinates RIP2 (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP oligomer [cytosol] (Homo sapiens)
NOD1:iE-DAP [cytosol] (Homo sapiens)
NOD1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y239 NOD1
Gene Names
NOD1, CARD4
Chain
chain:1-953
Reference Genes
BioGPS Gene:10392 NOD1
COSMIC (genes):NOD1 NOD1
CTD Gene:10392 NOD1
dbSNP Gene:10392 NOD1
ENSEMBL:ENSG00000106100 NOD1
ENSEMBL_homo_sapiens_GENE:ENSG00000106100.11 NOD1
HGNC:16390 NOD1
KEGG Gene (Homo sapiens):10392 NOD1
Monarch:10392 NOD1
NCBI Gene:10392 NOD1
OMIM:605980 NOD1
UCSC:Q9Y239 NOD1
Reference Transcript
RefSeq:XM_011515084.1 NOD1
RefSeq:NM_006092.2 NOD1
RefSeq:XM_006715633.2 NOD1
RefSeq:XM_011515080.2 NOD1
RefSeq:XM_005249568.1 NOD1
RefSeq:XM_011515079.1 NOD1
RefSeq:XM_017011675.1 NOD1
RefSeq:XM_005249572.1 NOD1
RefSeq:XM_011515081.2 NOD1
Other Identifiers
10392
11734125_a_at
11734126_a_at
11750550_a_at
11756913_s_at
17056328
221073_PM_s_at
221073_s_at
224190_PM_x_at
224190_x_at
3044073
3044074
3044075
3044077
3044078
3044080
3044082
3044083
3044085
3044086
3044092
3044093
3044094
3044095
3044096
3044097
3044100
3044101
3044102
3044103
3044105
3044106
3044121
65529_at
8138842
A_24_P129277
GE80439
GO:0000166
GO:0002221
GO:0002376
GO:0002606
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006914
GO:0006915
GO:0006919
GO:0006952
GO:0006954
GO:0007165
GO:0007254
GO:0008656
GO:0009595
GO:0010508
GO:0012501
GO:0016020
GO:0016045
GO:0016323
GO:0016324
GO:0016328
GO:0023052
GO:0031410
GO:0032731
GO:0032755
GO:0032757
GO:0032760
GO:0032874
GO:0034976
GO:0035556
GO:0038187
GO:0042742
GO:0042802
GO:0042803
GO:0042834
GO:0042981
GO:0043065
GO:0043123
GO:0043130
GO:0043226
GO:0043280
GO:0044877
GO:0045087
GO:0045335
GO:0046330
GO:0050700
GO:0050829
GO:0050830
GO:0051092
GO:0051403
GO:0060089
GO:0060907
GO:0070371
GO:0070374
GO:0070427
GO:0071225
GO:0097367
GO:0098542
GO:0098772
GO:0098792
GO:1901224
GO:1904417
HMNXSV003041422
HMNXSV003042575
ILMN_2114422
PH_hs_0001708
TC07001249.hg
g4760399_3p_a_at
g5174616_3p_a_at
Participates
as an input of
iE-DAP elicits a NOD1 response (Homo sapiens)
as a component of
NOD1:iE-DAP [cytosol] (Homo sapiens)
Inferred To
NOD1 [cytosol]
(Canis familiaris)
NOD1 [cytosol]
(Dictyostelium discoideum)
NOD1 [cytosol]
(Mus musculus)
nod1 [cytosol]
(Xenopus tropicalis)
Homologues of NOD1 [cytosol]
(Dictyostelium discoideum)
Nod1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
XP_011513382.1
,
XP_011513386.1
,
XP_011513383.1
,
XP_011513381.1
,
XP_005249625.1
,
XP_016867164.1
,
XP_006715696.1
,
XP_005249629.1
,
NP_006083.1
Guide to Pharmacology - Targets
1762
OpenTargets
ENSG00000106100
HPA
ENSG00000106100-NOD1
ZINC - Substances
NOD1_HUMAN
GeneCards
Q9Y239
ZINC target
Q9Y239
Ensembl
ENST00000222823
,
ENSG00000106100
,
ENSP00000222823
PRO
Q9Y239
Pharos - Targets
Q9Y239
ZINC - Predictions - Purchasable
NOD1_HUMAN
PDB
2NSN
,
2NZ7
,
4JQW
,
2DBD
,
4E9M
,
2B1W
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43353 RIPK2
2
RIPK2 [cytosol]
(R-HSA-168402)
Ub-209-RIPK2 [cytosol]
(R-HSA-706483)
0.762
6
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.589
2
UniProt:Q9Y2Z0 SUGT1
1
SUGT1 [cytosol]
(R-HSA-874107)
0.564
5
UniProt:Q9Y239 NOD1
1
NOD1 [cytosol]
(R-HSA-168407)
0.558
2
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q13153 PAK1
5
PAK1 [plasma membrane]
(R-HSA-3928409)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
Active PAK1 [cytosol]
(R-HSA-8964622)
PAK1 [cytosol]
(R-HSA-162629)
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
0.556
3
UniProt:Q53GS7 GLE1
1
GLE1 [nucleoplasm]
(R-HSA-8932905)
0.556
3
UniProt:P02545 LMNA
3
LMNA(1-646) [nuclear envelope]
(R-HSA-535479)
LMNA(1-567)-RAF1(279-648) fusion [cytosol]
(R-HSA-6802399)
LMNA(1-567)-p-RAF1(279-648) fusion [cytosol]
(R-HSA-6802537)
0.556
3
UniProt:P02489 CRYAA
0.556
3
UniProt:Q92876 KLK6
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
9
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:A0A0H3NF38 A0A0H3NF38
0.499
4
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