Reactome | NOD2 [cytosol]

NOD2 [cytosol]

Stable Identifier

R-HSA-168411

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Caspase recruitment domain protein 15

Locations in the PathwayBrowser for interactor UniProt:Q9P0J0 NDUFA13

Expand all

External Reference Information

External Reference

UniProt:Q9HC29 NOD2

Gene Names

NOD2, CARD15, IBD1

Chain

chain:1-1040

Reference Genes

BioGPS Gene:64127 NOD2

COSMIC (genes):NOD2 NOD2

CTD Gene:64127 NOD2

dbSNP Gene:64127 NOD2

ENSEMBL:ENSG00000167207 NOD2

ENSEMBL_homo_sapiens_GENE:ENSG00000167207.15 NOD2

HGNC:5331 NOD2

KEGG Gene (Homo sapiens):64127 NOD2

Monarch:64127 NOD2

NCBI Gene:64127 NOD2

OMIM:605956 NOD2

UCSC:Q9HC29 NOD2

Reference Transcript

Other Identifiers

11731340_at

11750212_a_at

16818820

220066_PM_at

220066_at

3660179

3660181

3660182

3660183

3660189

3660191

3660193

3660194

3660195

3660201

3660202

3660203

3660204

3660205

3660206

3660207

3660209

3660210

64127

75064_at

7995539

A_23_P420863

A_23_P77389

GE553808

GO:0000165

GO:0000166

GO:0001659

GO:0002221

GO:0002227

GO:0002250

GO:0002253

GO:0002376

GO:0002606

GO:0002710

GO:0002720

GO:0002732

GO:0002815

GO:0002830

GO:0002862

GO:0002925

GO:0003779

GO:0005515

GO:0005524

GO:0005737

GO:0005739

GO:0005794

GO:0005829

GO:0005856

GO:0005886

GO:0006351

GO:0006355

GO:0006909

GO:0006914

GO:0006952

GO:0006954

GO:0006963

GO:0006965

GO:0007005

GO:0007155

GO:0007254

GO:0007584

GO:0008092

GO:0008284

GO:0009595

GO:0009986

GO:0010508

GO:0010936

GO:0012501

GO:0016020

GO:0016045

GO:0016192

GO:0016323

GO:0019897

GO:0019899

GO:0019901

GO:0022600

GO:0023052

GO:0030277

GO:0030544

GO:0031398

GO:0031410

GO:0031982

GO:0032098

GO:0032494

GO:0032495

GO:0032496

GO:0032498

GO:0032500

GO:0032689

GO:0032695

GO:0032701

GO:0032703

GO:0032720

GO:0032731

GO:0032733

GO:0032735

GO:0032740

GO:0032755

GO:0032757

GO:0032760

GO:0032874

GO:0032991

GO:0034134

GO:0034136

GO:0034976

GO:0035556

GO:0036211

GO:0036335

GO:0038187

GO:0042742

GO:0042834

GO:0042981

GO:0043123

GO:0043130

GO:0043226

GO:0043330

GO:0043410

GO:0043531

GO:0044877

GO:0045087

GO:0045089

GO:0045335

GO:0045747

GO:0045944

GO:0046330

GO:0046645

GO:0048870

GO:0048874

GO:0050679

GO:0050700

GO:0050727

GO:0050731

GO:0050766

GO:0050830

GO:0050871

GO:0051092

GO:0051403

GO:0051649

GO:0051770

GO:0051879

GO:0060089

GO:0060907

GO:0070371

GO:0070374

GO:0070431

GO:0071222

GO:0071224

GO:0071225

GO:0071407

GO:0071639

GO:0090022

GO:0097367

GO:0098542

GO:0098792

GO:0140367

GO:1900017

GO:1901224

GO:1901526

GO:1902523

GO:1904417

GO:2000110

HMNXSV003012580

HMNXSV003020150

ILMN_1762594

PH_hs_0008160

TC16000442.hg

TC16001548.hg

TC16001549.hg

g11545911_3p_at

Participates

as a component of

as an input of

Inferred To

nod2 [cytosol] (Danio rerio)

NOD2 [cytosol] (Bos taurus)

NOD2 [cytosol] (Canis familiaris)

NOD2 [cytosol] (Dictyostelium discoideum)

NOD2 [cytosol] (Mus musculus)

Nod2 [cytosol] (Rattus norvegicus)

Homologues of NOD2 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_071445.1, XP_005256141.1, NP_001280486.1

Guide to Pharmacology - Targets

1763

OpenTargets

ENSG00000167207

ZINC - Substances

NOD2_HUMAN

ZINC target

Q9HC29

PRO

Q9HC29

GeneCards

Q9HC29

HPA

ENSG00000167207-NOD2

Ensembl

ENST00000300589, ENST00000647318, ENSP00000495993, ENSG00000167207, ENSP00000300589

Pharos - Targets

Q9HC29

ZINC - Predictions - Purchasable

NOD2_HUMAN

Orphanet

16556

HMDB Protein

HMDBP13949

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43353 RIPK2	2	RIPK2 [cytosol] (R-HSA-168402) Ub-209-RIPK2 [cytosol] (R-HSA-706483)	0.734	4
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.725	7
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.664	10
UniProt:Q96RT1 ERBIN	1	ERBIN [plasma membrane] (R-HSA-1358718)	0.664	5
UniProt:P29466 CASP1	5	CASP1(1-119) [cytosol] (R-HSA-448680) CASP1(120-297) [cytosol] (R-HSA-448686) CASP1(317-404) [cytosol] (R-HSA-448704) CASP1(298-316) [cytosol] (R-HSA-448674) CASP1(1-404) [cytosol] (R-HSA-448692)	0.591	4
UniProt:Q96RT1-2 ERBIN			0.581	5
UniProt:Q9P0J0 NDUFA13	8	NDUFA13 [mitochondrial inner membrane] (R-HSA-59936) NDUFA13(41-49) [mitochondrial inner membrane] (R-HSA-9839958) NDUFA13(100-108) [mitochondrial inner membrane] (R-HSA-9839959) NDUFA13(109-144) [mitochondrial inner membrane] (R-HSA-9839968) NDUFA13(2-19) [mitochondrial inner membrane] (R-HSA-9839966) NDUFA13(69-99) [mitochondrial inner membrane] (R-HSA-9839964) NDUFA13(20-40) [mitochondrial inner membrane] (R-HSA-9839963) NDUFA13(50-68) [mitochondrial inner membrane] (R-HSA-9839961)	0.543	6
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.527	2
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.508	2
UniProt:Q16537 PPP2R5E	1	PPP2R5E [cytosol] (R-HSA-1638770)	0.508	2
UniProt:Q10471 GALNT2	2	GALNT2(1-571) [endoplasmic reticulum membrane] (R-HSA-8849322) GALNT2(1-571) [Golgi membrane] (R-HSA-913618)	0.508	2
UniProt:Q9Y3D6 FIS1	2	FIS1 [peroxisomal membrane] (R-HSA-9033123) FIS1 [cytosol] (R-HSA-9033099)	0.508	2
UniProt:Q04724 TLE1	2	Ub-TLE1 [nucleoplasm] (R-HSA-3322369) TLE1 [nucleoplasm] (R-HSA-212327)	0.508	2