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About
What is Reactome ?
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Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
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How do I search ?
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MDP:NOD2 [cytosol]
Stable Identifier
R-HSA-168414
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
Activated NOD oligomer recruites RIP2 (RICK) (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
Activated NOD2 oligomerizes (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
CARD9 binds RIP2 (and NOD2) (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:CARD9 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
CYLD deubiquitinates NEMO (Homo sapiens)
PAMP:NOD oligomer:RIP2:K63-Ub-K285-NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
K63 polyubiquitinated RIP2 associates with the TAK1 complex (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
MDP elicits a NOD2 response (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
RIP2 binds NEMO (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
RIP2 induces K63-linked ubiquitination of NEMO (Homo sapiens)
PAMP:NOD oligomer:RIP2:K63-Ub-K285-NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
RIP2 is K63 polyubiquitinated (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
TAK1 is activated (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
TNFAIP3 (A20) deubiquitinates RIP2 (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ovarian tumor domain proteases (Homo sapiens)
TNFAIP3 (A20) deubiquitinates RIP2 (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
Participants
components
MDP [cytosol]
NOD2 [cytosol]
(Homo sapiens)
Participates
as an output of
MDP elicits a NOD2 response (Homo sapiens)
as an input of
Activated NOD2 oligomerizes (Homo sapiens)
as a component of
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
Inferred To
MDP:NOD2 [cytosol]
(Bos taurus)
MDP:NOD2 [cytosol]
(Canis familiaris)
MDP:NOD2 [cytosol]
(Danio rerio)
MDP:NOD2 [cytosol]
(Dictyostelium discoideum)
MDP:NOD2 [cytosol]
(Mus musculus)
MDP:NOD2 [cytosol]
(Rattus norvegicus)
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