Reactome | EIF2AK2 [cytosol]

EIF2AK2 [cytosol]

Stable Identifier

R-HSA-168699

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PKR, Double stranded RNA activated protein kinase (PKR)

Locations in the PathwayBrowser for interactor UniProt:P06748 NPM1

Expand all

External Reference Information

External Reference

UniProt:P19525 EIF2AK2

Gene Names

EIF2AK2, PKR, PRKR

Chain

initiator methionine:1, chain:2-551

Reference Genes

BioGPS Gene:5610 EIF2AK2

COSMIC (genes):EIF2AK2 EIF2AK2

CTD Gene:5610 EIF2AK2

dbSNP Gene:5610 EIF2AK2

ENSEMBL:ENSG00000055332 EIF2AK2

HGNC:9437 EIF2AK2

KEGG Gene (Homo sapiens):5610 EIF2AK2

Monarch:5610 EIF2AK2

NCBI Gene:5610 EIF2AK2

OMIM:176871 EIF2AK2

UCSC:P19525 EIF2AK2

Reference Transcript

Other Identifiers

0002360278

1008_f_at

11730991_a_at

11730992_x_at

16896442

204211_PM_x_at

204211_x_at

213294_PM_at

213294_at

238743_PM_at

238743_at

242898_PM_at

242898_at

2548403

2548404

2548405

2548406

2548407

2548408

2548409

2548410

2548412

2548414

2548417

2548418

2548420

2548421

2548422

2548426

2548427

2548428

2548429

2548430

2548431

2548433

2548434

2548435

2548436

2548441

38662_at

5610

61940_at

80047_at

8051501

85147_at

A_19_P00804527

A_32_P38003

A_33_P3224858

GE61104

GO:0000166

GO:0001819

GO:0002376

GO:0003674

GO:0003723

GO:0003725

GO:0004672

GO:0004674

GO:0004694

GO:0004712

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0006464

GO:0006468

GO:0006950

GO:0007165

GO:0008150

GO:0008219

GO:0008283

GO:0008285

GO:0009058

GO:0009615

GO:0010998

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0017148

GO:0018108

GO:0019888

GO:0022607

GO:0030154

GO:0030234

GO:0030968

GO:0032722

GO:0032874

GO:0033689

GO:0034198

GO:0034641

GO:0035455

GO:0042802

GO:0043066

GO:0043167

GO:0043226

GO:0043410

GO:0045071

GO:0045087

GO:0046777

GO:0048471

GO:0048856

GO:0050790

GO:0051092

GO:0051607

GO:0065003

GO:0106310

GO:1900225

GO:1901224

GO:1901532

GO:1902033

GO:1902036

HMNXSV003049578

Hs.169816.0.A1_3p_at

Hs.271866.0.A1_3p_at

Hs.306117.1.A1_3p_at

ILMN_1706502

PH_hs_0025752

TC02001739.hg

TC02004161.hg

U50648_s_at

g4506102_3p_at

Participates

as a candidate of

ISG15 targets [cytosol] (Homo sapiens)

as a component of

NS1 Homodimer:PKR Complex [cytosol] (Homo sapiens)

as an input of

Binding of NS1 to PKR (Homo sapiens)

Inferred To

Eif2ak2 [cytosol] (Mus musculus)

Eif2ak2 [cytosol] (Rattus norvegicus)

Homologues of EIF2AK2 [cytosol] (Caenorhabditis elegans)

Homologues of EIF2AK2 [cytosol] (Dictyostelium discoideum)

EIF2AK2 [cytosol] (Bos taurus)

EIF2AK2 [cytosol] (Caenorhabditis elegans)

EIF2AK2 [cytosol] (Canis familiaris)

EIF2AK2 [cytosol] (Dictyostelium discoideum)

EIF2AK2 [cytosol] (Sus scrofa)

pek-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002750.1, XP_011531289.1, NP_001129123.1, NP_001129124.1

Guide to Pharmacology - Targets

2016

OpenTargets

ENSG00000055332

IntEnz

2.7.10.2, 2.7.11.1

HPA

ENSG00000055332-EIF2AK2

GeneCards

P19525

ZINC target

P19525

Ensembl

ENST00000681507, ENSP00000385014, ENSP00000506024, ENSP00000505772, ENST00000405334, ENSG00000055332, ENST00000233057, ENSP00000233057, ENSP00000497534, ENSP00000505138, ENST00000681463, ENSP00000378559, ENST00000395127, ENST00000647926, ENST00000679507

PRO

P19525

Pharos - Targets

P19525

HMDB Protein

HMDBP08840

PDB

2A1A, 2A19, 3UIU, 6D3K, 1QU6, 6D3L

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.822	8
UniProt:O75569 PRKRA	1	PRKRA [cytosol] (R-HSA-2399897)	0.8	6
UniProt:P05198 EIF2S1	2	p-S52-EIF2S1 [cytosol] (R-HSA-381060) EIF2S1 [cytosol] (R-HSA-72510)	0.783	5
UniProt:Q7L2E3 DHX30			0.708	4
UniProt:P27958-PRO_0000037576			0.698	5
UniProt:P27958-PRO_0000037570			0.684	4
UniProt:P20639 K3			0.667	3
UniProt:Q9UL40 ZN346			0.623	3
UniProt:Q9HCE1 MOV10	1	MOV10 [cytosol] (R-HSA-427772)	0.623	3
UniProt:Q9NUL3 STAU2			0.623	3
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.623	3
UniProt:Q96P20 NLRP3	2	K63polyUb-NLRP3 [cytosol] (R-HSA-6783288) NLRP3 [cytosol] (R-HSA-561189)	0.602	6
UniProt:Q27968 DNJC3			0.591	5
UniProt:P04487 RNB			0.591	3
UniProt:P19525 EIF2AK2	1	EIF2AK2 [cytosol] (R-HSA-168699)	0.558	2
UniProt:P78563-4 ADARB1			0.556	3
UniProt:O75569-1 PRKRA			0.544	3
UniProt:Q9NZM5 NOP53			0.527	2
UniProt:Q8WTT2 NOC3L			0.527	2
UniProt:Q14684 RRP1B			0.527	2
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.527	2
UniProt:Q9BZE4 GTPB4			0.527	2
UniProt:Q9NX58 LYAR			0.527	2
UniProt:Q00577 PURA			0.527	2
UniProt:Q6P2E9 EDC4	1	EDC4 [cytosol] (R-HSA-429963)	0.499	2
UniProt:P56537 IF6			0.499	2
UniProt:Q15633 TARBP2	1	TARBP2 [cytosol] (R-HSA-203864)	0.499	2
UniProt:Q9UPY3 DICER1	1	DICER1 [cytosol] (R-HSA-203820)	0.499	2
UniProt:Q96C10 DHX58	1	DHX58 [cytosol] (R-HSA-913540)	0.499	2
UniProt:Q9H0E2 TOLLIP	4	TOLLIP [cytosol] (R-HSA-446885) TOLLIP [azurophil granule lumen] (R-HSA-6799709) TOLLIP [extracellular region] (R-HSA-6800448) TOLLIP [specific granule lumen] (R-HSA-6799719)	0.499	2
UniProt:Q08211 DHX9	2	DHX9 [cytosol] (R-HSA-847700) DHX9 [nucleoplasm] (R-HSA-53517)	0.499	2
UniProt:P06748 NPM1	10	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y ALK(1068-1620) fusion [cytosol] (R-HSA-9730703)	0.463	3

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