NA activation of TGF-beta

Stable Identifier
R-HSA-168865
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
plasma membrane
ReviewStatus
5/5
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NA activation of TGF-beta
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Influenza A virus induces apoptosis in a variety of ways including by activation of host TGF-beta by viral neuraminidase (NA).
Literature References
PubMed ID Title Journal Year
9934696 Role of neuraminidase in influenza virus-induced apoptosis

Hiscox, SA, Sweet, C, Barnett, JM, Smith, H, Price, GE, Morris, SJ

J Gen Virol 1999
25535343 Influenza viral neuraminidase primes bacterial coinfection through TGF-β-mediated expression of host cell receptors

Fan, X, Cleary, P, Gao, GF, Wang, X, Wang, B, Ren, A, Li, N, Zhao, Y

Proc. Natl. Acad. Sci. U.S.A. 2015
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
induction by virus of host immune response (0046730)
Catalyst Activity

peptidase activator activity of NA [extracellular region]

Physical Entity
NA [extracellular region] (Influenza A virus)
Activity
peptidase activator activity (GO:0016504)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Gillespie, ME  (2013-11-18)
Reviewed
Gale M, Jr  (2004-05-12)
Created
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