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Accumulation of M1 at the inner leaflet of the lipid bilayer
Stable Identifier
R-HSA-168894
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
Virus Assembly and Release (Homo sapiens)
Assembly of Viral Components at the Budding Site (Homo sapiens)
Accumulation of M1 at the inner leaflet of the lipid bilayer (Homo sapiens)
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There is evidence for the association of M1 with lipid rafts in influenza infected cells, whereas M1 expressed alone remains soluble (Ali et al., 2000; Zhang and Lamb, 1996), suggesting association of M1 with other viral proteins in targetting to the cell membrane. Coexpression of HA and NA together with M1 has been shown to promote raft association of M1. This association requires the TMD and cytoplasmic tails of HA and NA (Ali et al, 2000; Zhang et al, 2000). This is consistent with M1 becoming associated with HA and NA during their passage through the exocytic pathway to raft domains in the apical membrane. alternatively M1 may use the cytoskeleton to reach the virus assembly site, as M1 interacts with cytoskeletal components (Alvalos et al., 1997). The M1 interaction depends on the presence of RNP and is most likely mediated by direct binding of F-actin by NP (Digard et al., 1999).
Literature References
PubMed ID
Title
Journal
Year
8918911
Characterization of the membrane association of the influenza virus matrix protein in living cells
Lamb, RA
,
Zhang, J
Virology
1996
Participants
Input
M1 [cytosol]
(Influenza A virus)
Output
M1 [plasma membrane]
(Influenza A virus)
Participates
as an event of
Assembly of Viral Components at the Budding Site (Homo sapiens)
Event Information
Go Biological Process
virion assembly (0019068)
Disease
Name
Identifier
Synonyms
influenza
DOID:8469
Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Steel, J (2007-05-01)
Reviewed
Squires, B (2007-05-01)
Rush, MG (2007-05-01)
Created
© 2025
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