RIP1 modification with Lys-63 polyubiquitin chains was shown to be essential for TNF-induced activation of NF-kB (Ea et al. 2006). It is thought that TRAF family members mediate this Lys63-linked ubiquitination of RIP1 (Wertz et al. 2004, Tada et al 2001, Vallabhapurapu and Karin 2009), which may facilitate recruitment of the TAK1 complex and thus activation of NF-kB. Binding of NEMO to Lys63-linked polyubiquitinated RIP1 is also required in the signaling cascade from the activated receptor to the IKK-mediated NF-kB activation (Wu et al. 2006).
Deng, L, Chen, ZJ, Pineda, G, Xia, ZP, Ea, CK
Roelandt, R, De Medts, J, Vandenabeele, P, Staes, A, Gilbert, B, Bertrand, MJ, Lippens, S, Declercq, W, Gevaert, K
ubiquitin-protein transferase activity of RIP1 ubiqutin ligases [cytosol]
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