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Crk's SH3 domain engages C3G
Stable Identifier
R-HSA-169895
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Prolonged ERK activation events (Homo sapiens)
ARMS-mediated activation (Homo sapiens)
Crk's SH3 domain engages C3G (Homo sapiens)
General
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SBGN
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Rap guanine nucleotide exchange factor 1 (RAPGEF1, C3G) is a guanine nucleotide exchange factor for Rap1, which is recruited by Crk adaptor proteins (Knudsen et al. 1994; York, 1998).
Literature References
PubMed ID
Title
Journal
Year
16284401
Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation
Arevalo, JC
,
Teng, KK
,
Pereira, DB
,
Yano, H
,
Chao, MV
J Biol Chem
2006
Participants
Input
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane]
(Homo sapiens)
Output
Active TrkA receptor:Phospho-ARMS:Crk:C3G complex [plasma membrane]
(Homo sapiens)
Participates
as an event of
ARMS-mediated activation (Homo sapiens)
Orthologous Events
Crk's SH3 domain engages C3G (Bos taurus)
Crk's SH3 domain engages C3G (Canis familiaris)
Crk's SH3 domain engages C3G (Danio rerio)
Crk's SH3 domain engages C3G (Gallus gallus)
Crk's SH3 domain engages C3G (Mus musculus)
Crk's SH3 domain engages C3G (Rattus norvegicus)
Crk's SH3 domain engages C3G (Sus scrofa)
Crk's SH3 domain engages C3G (Xenopus tropicalis)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Greene, LA (2007-11-08)
Created
Jassal, B (2005-12-16)
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