Regulation of Apoptosis

Stable Identifier
R-HSA-169911
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Regulation of Apoptosis
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A regulated balance between cell survival and apoptosis is essential for normal development and homeostasis of multicellular organisms (see Matsuzawa, 2001). Defects in control of this balance may contribute to autoimmune disease, neurodegeneration and cancer. Protein ubiquitination and degradation is one of the major mechanisms that regulate apoptotic cell death (reviewed in Yang and Yu 2003).
Literature References
PubMed ID Title Journal Year
12724336 Regulation of apoptosis: the ubiquitous way

Yu, X, Yang, Y

FASEB J 2003
11432772 Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1

Matsuzawa, A, Ichijo, H

J Biochem 2001
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Event Information
Go Biological Process
regulation of apoptotic process (0042981)
Orthologous Events
Regulation of Apoptosis (Bos taurus)
Regulation of Apoptosis (Canis familiaris)
Regulation of Apoptosis (Danio rerio)
Regulation of Apoptosis (Dictyostelium discoideum)
Regulation of Apoptosis (Gallus gallus)
Regulation of Apoptosis (Mus musculus)
Regulation of Apoptosis (Rattus norvegicus)
Regulation of Apoptosis (Saccharomyces cerevisiae)
Regulation of Apoptosis (Schizosaccharomyces pombe)
Regulation of Apoptosis (Sus scrofa)
Regulation of Apoptosis (Xenopus tropicalis)
Authored
Jakobi, R  (2008-02-05)
Reviewed
Chang, E  (2008-05-21)
Created
Gopinathrao, G  (2005-12-16)
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