Protons are translocated from the intermembrane space to the matrix

Stable Identifier
R-HSA-170026
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In this reaction, 1 molecule of 'H+' is translocated from mitochondrial intermembrane space to mitochondrial matrix.

This reaction takes place in the 'mitochondrial inner membrane' and is mediated by the 'hydrogen ion transporter activity' of 'UCP dimer' (Echtay et al. 2002a, Echtay et al. 2002b).

Literature References
PubMed ID Title Journal Year
12372827 Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants

Echtay, KS, Murphy, MP, Smith, RA, Talbot, DA, Brand, MD

J. Biol. Chem. 2002
11780125 Superoxide activates mitochondrial uncoupling proteins

Echtay, KS, Roussel, D, St-Pierre, J, Jekabsons, MB, Cadenas, S, Stuart, JA, Harper, JA, Roebuck, SJ, Morrison, A, Pickering, S, Clapham, JC, Brand, MD

Nature 2002
Participants
Participates
Catalyst Activity

proton transmembrane transporter activity of UCP dimer [mitochondrial inner membrane]

This event is regulated
Negatively by
Positively by
Regulator
Orthologous Events
Cross References
Rhea
Created
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