Protons are translocated from the intermembrane space to the matrix

Stable Identifier
R-HSA-170026
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
ReviewStatus
5/5
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Protons are translocated from the intermembrane space to the matrix
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In this reaction, 1 molecule of 'H+' is translocated from mitochondrial intermembrane space to mitochondrial matrix.

This reaction takes place in the 'mitochondrial inner membrane' and is mediated by the 'hydrogen ion transporter activity' of 'UCP dimer' (Echtay et al. 2002a, Echtay et al. 2002b).
Literature References
PubMed ID Title Journal Year
11780125 Superoxide activates mitochondrial uncoupling proteins

Pickering, S, Harper, JA, St-Pierre, J, Clapham, JC, Morrison, A, Stuart, JA, Brand, MD, Roebuck, SJ, Jekabsons, MB, Roussel, D, Cadenas, S, Echtay, KS

Nature 2002
12372827 Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants

Smith, RA, Talbot, DA, Brand, MD, Murphy, MP, Echtay, KS

J. Biol. Chem. 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

proton transmembrane transporter activity of UCP dimer [mitochondrial inner membrane]

Physical Entity
UCP dimer [mitochondrial inner membrane] (Homo sapiens)
Activity
proton transmembrane transporter activity (GO:0015078)
This event is regulated
Negatively by
Regulator
Purine nucleotide [cytosol]
Positively by
Regulator
LCFA [cytosol]
Orthologous Events
Protons are translocated from the intermembrane space to the matrix (Bos taurus)
Protons are translocated from the intermembrane space to the matrix (Caenorhabditis elegans)
Protons are translocated from the intermembrane space to the matrix (Canis familiaris)
Protons are translocated from the intermembrane space to the matrix (Danio rerio)
Protons are translocated from the intermembrane space to the matrix (Drosophila melanogaster)
Protons are translocated from the intermembrane space to the matrix (Gallus gallus)
Protons are translocated from the intermembrane space to the matrix (Mus musculus)
Protons are translocated from the intermembrane space to the matrix (Rattus norvegicus)
Protons are translocated from the intermembrane space to the matrix (Sus scrofa)
Protons are translocated from the intermembrane space to the matrix (Xenopus tropicalis)
Cross References
Rhea
Created
Jassal, B  (2005-12-20)
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