Protons are translocated from the intermembrane space to the matrix

Stable Identifier
Reaction [transition]
Homo sapiens
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In this reaction, 1 molecule of 'H+' is translocated from mitochondrial intermembrane space to mitochondrial matrix.

This reaction takes place in the 'mitochondrial inner membrane' and is mediated by the 'hydrogen ion transporter activity' of 'UCP dimer' (Echtay et al. 2002a, Echtay et al. 2002b).

Literature References
PubMed ID Title Journal Year
11780125 Superoxide activates mitochondrial uncoupling proteins

Pickering, S, Harper, JA, St-Pierre, J, Clapham, JC, Morrison, A, Stuart, JA, Brand, MD, Roebuck, SJ, Jekabsons, MB, Roussel, D, Cadenas, S, Echtay, KS

Nature 2002
12372827 Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants

Smith, RA, Talbot, DA, Brand, MD, Murphy, MP, Echtay, KS

J. Biol. Chem. 2002
Catalyst Activity

proton transmembrane transporter activity of UCP dimer [mitochondrial inner membrane]

This event is regulated
Negatively by