Reactome | p-4S-CCNB1 [cytosol]

p-4S-CCNB1 [cytosol]

Stable Identifier

R-HSA-170058

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S126,S128,S133,S144-CCNB1, phospho-Cyclin B1 (CRS)

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General

At the onset of mitosis, Cyclin B1 is phosphorylated in the CRS region. The identity of the kinase(s) responsible for this phosphorylation have not yet been determined with certainty.

External Reference Information

External Reference

UniProt:P14635 CCNB1

Gene Names

CCNB1, CCNB

Chain

chain:1-433

Reference Genes

BioGPS Gene:891 CCNB1

COSMIC (genes):CCNB1 CCNB1

CTD Gene:891 CCNB1

dbSNP Gene:891 CCNB1

ENSEMBL:ENSG00000134057 CCNB1

HGNC:1579 CCNB1

KEGG Gene (Homo sapiens):891 CCNB1

Monarch:891 CCNB1

NCBI Gene:891 CCNB1

OMIM:123836 CCNB1

UCSC:P14635 CCNB1

Reference Transcript

RefSeq:NM_031966.3 CCNB1

Other Identifiers

0000770053

11723939_a_at

16985599

1945_at

214710_s_at

228729_at

2813416

2813417

2813418

2813419

2813421

2813422

2813423

2813424

2813425

2813427

2813429

2813432

2813434

2813435

2813436

2813437

34736_at

63638_at

8105828

891

A_23_P122197

A_33_P3401621

GE57886

GO:0000003

GO:0000079

GO:0000086

GO:0000228

GO:0000278

GO:0000307

GO:0000922

GO:0000942

GO:0001556

GO:0001701

GO:0001933

GO:0003674

GO:0005113

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005759

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006091

GO:0006397

GO:0006464

GO:0006468

GO:0006950

GO:0006977

GO:0007010

GO:0007049

GO:0007052

GO:0007059

GO:0007076

GO:0007077

GO:0007080

GO:0007084

GO:0007165

GO:0007283

GO:0008150

GO:0008283

GO:0009056

GO:0009058

GO:0009612

GO:0009636

GO:0009790

GO:0010629

GO:0010971

GO:0016020

GO:0016538

GO:0019899

GO:0019901

GO:0021700

GO:0022607

GO:0030154

GO:0030234

GO:0031145

GO:0031442

GO:0032991

GO:0033129

GO:0034641

GO:0040007

GO:0042246

GO:0042493

GO:0043226

GO:0044389

GO:0044772

GO:0045737

GO:0045787

GO:0045931

GO:0046680

GO:0048146

GO:0048565

GO:0048856

GO:0051276

GO:0051301

GO:0051726

GO:0051987

GO:0055015

GO:0060045

GO:0060260

GO:0060623

GO:0061024

GO:0061575

GO:0065003

GO:0071283

GO:0071398

GO:0071407

GO:0071456

GO:0090266

GO:0097125

GO:0140014

GO:1901990

GO:1905448

GO:2000775

HMNXSV003039343

Hs.23960.0.S1_3p_at

Hs.23960.2.S1_3p_a_at

ILMN_1712803

M25753_at

PH_hs_0002110

TC05000298.hg

TC05002418.hg

Participates

as a component of

Other forms of this molecule

CCNB1 [nucleoplasm]

CCNB1 [cytosol]

p-4S-CCNB1 [nucleoplasm]

Inferred To

phospho-CycB [cytosol] (Drosophila melanogaster)

phospho-cyb-2.1 [cytosol] (Caenorhabditis elegans)

phospho-ccnb1 [cytosol] (Danio rerio)

phospho-cyb-2.2 [cytosol] (Caenorhabditis elegans)

phospho-p-4S-CCNB1 [cytosol] (Canis familiaris)

phospho-p-4S-CCNB1 [cytosol] (Sus scrofa)

phospho-p-4S-CCNB1 [cytosol] (Xenopus tropicalis)

Homologues of p-4S-CCNB1 [cytosol] (Caenorhabditis elegans)

Homologues of p-4S-CCNB1 [cytosol] (Canis familiaris)

phospho-Ccnb1 [cytosol] (Mus musculus)

phospho-Ccnb1 [cytosol] (Rattus norvegicus)

phospho-CCNB1 [cytosol] (Canis familiaris)

phospho-cyb-1 [cytosol] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-serine at 126

Coordinate

126

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 128

Coordinate

128

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 133

Coordinate

133

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 144

Coordinate

144

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_114172.1

OpenTargets

ENSG00000134057

HPA

ENSG00000134057-CCNB1

ZINC - Substances

CCNB1_HUMAN

GeneCards

P14635

ZINC target

P14635

Ensembl

ENST00000256442, ENST00000505500, ENSP00000256442, ENSG00000134057, ENSP00000424588

PRO

P14635

Pharos - Targets

P14635

ZINC - Predictions - Purchasable

CCNB1_HUMAN

GlyGen

P14635

PDB

6GU3, 5LQF, 2JGZ, 6GU2, 2B9R, 6GU4, 5HQ0, 4Y72, 4YC3

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06493 CDK1	10	CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) CDK1 [cytosol] (R-HSA-170075) p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078)	0.969	22
UniProt:P24941 CDK2	5	p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.788	7
UniProt:Q00535 CDK5	4	p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [nucleoplasm] (R-HSA-8863586) CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809)	0.725	4
UniProt:Q99640 PKMYT1	3	PKMYT1 [nucleoplasm] (R-HSA-74386) p-PKMYT1 [nucleoplasm] (R-HSA-162650) PKMYT1 [cytosol] (R-HSA-157457)	0.713	5
UniProt:P38936 CDKN1A	5	p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585)	0.65	3
UniProt:P11440 Cdk1	10	phospho-Cdk1 [nucleoplasm] (R-MMU-170074) phospho-Cdk1 [nucleoplasm] (R-MMU-170078) phospho-Cdk1 [nucleoplasm] (R-MMU-170045) phospho-Cdk1 [cytosol] (R-MMU-170064) phospho-Cdk1 [cytosol] (R-MMU-170071) phospho-Cdk1 [cytosol] (R-MMU-157415) phospho-Cdk1 [nucleoplasm] (R-MMU-170066) Cdk1 [cytosol] (R-MMU-170075) Cdk1 [nucleoplasm] (R-MMU-1362302) Cdk1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.623	4
UniProt:O75618-1 DEDD			0.576	3
UniProt:Q12778 FOXO1	5	FOXO1 [nucleoplasm] (R-HSA-199300) p-S215 FOXO1 [nucleoplasm] (R-HSA-5692651) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942)	0.571	2
UniProt:P46527 CDKN1B	8	CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.564	2
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.527	2
UniProt:Q9NPC3 CIP1			0.527	2
UniProt:P33552 CKS2			0.527	2
UniProt:Q13635 PTCH1	4	ub-PTCH1 [endocytic vesicle membrane] (R-HSA-5632520) PTCH1 [plasma membrane] (R-HSA-445133) ub-PTCH1 [ciliary membrane] (R-HSA-5632517) PTCH1 [ciliary membrane] (R-HSA-5610415)	0.499	2
UniProt:Q14674 ESPL1	4	ESPL1(1507-1535) [cytosol] (R-HSA-2500272) ESPL1(1-1506) [cytosol] (R-HSA-2467768) ESPL1(1536-2120) [cytosol] (R-HSA-2467767) ESPL1 [cytosol] (R-HSA-1638167)	0.462	2

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