Full activity of most CDKs is dependent on CAK mediated phosphorylation at a conserved residue (Thr 161 in Cdc2). This modification is thought to improve substrate binding. High affinity binding of Cyclin A within the Cyclin A:Cdc2 complex requires this phosphorylation (Desai et al 1995).
Wessling, HC, Desai, D, Fisher, RP, Morgan, DO
protein serine/threonine kinase activity of CAK [nucleoplasm]
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