Phosphorylation of Cyclin B1 in the CRS domain

Stable Identifier
R-HSA-170126
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylation of Cyclin B1 in the CRS domain
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At the onset of mitosis, cyclin B is phosphorylated in the CRS sequence which creates a nuclear import signal in the amino terminus. The kinase(s) responsible for this phosphorylation are not yet known (Hagting et al., 1999).
Literature References
PubMed ID Title Journal Year
10395539 Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal

Pines, J, Hagting, A, Simpson, K, Jackman, M

Curr Biol 1999
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Catalyst Activity

protein serine/threonine kinase activity of CRS kinase [cytosol]

Physical Entity
CRS kinase [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of Cyclin B1 in the CRS domain (Bos taurus)
Phosphorylation of Cyclin B1 in the CRS domain (Caenorhabditis elegans)
Phosphorylation of Cyclin B1 in the CRS domain (Canis familiaris)
Phosphorylation of Cyclin B1 in the CRS domain (Danio rerio)
Phosphorylation of Cyclin B1 in the CRS domain (Drosophila melanogaster)
Phosphorylation of Cyclin B1 in the CRS domain (Mus musculus)
Phosphorylation of Cyclin B1 in the CRS domain (Rattus norvegicus)
Phosphorylation of Cyclin B1 in the CRS domain (Sus scrofa)
Phosphorylation of Cyclin B1 in the CRS domain (Xenopus tropicalis)
Created
Matthews, L  (2005-12-23)
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