Reactome | TGFBR2 [plasma membrane]

TGFBR2 [plasma membrane]

Stable Identifier

R-HSA-170842

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

TGF-beta II receptor

Icon

Locations in the PathwayBrowser for interactor UniProt:P15036 ETS2

Expand all

External Reference Information

External Reference

UniProt:P37173 TGFBR2

Gene Names

TGFBR2

Chain

signal peptide:1-22, chain:23-567

Reference Genes

BioGPS Gene:7048 TGFBR2

COSMIC (genes):TGFBR2 TGFBR2

CTD Gene:7048 TGFBR2

dbSNP Gene:7048 TGFBR2

ENSEMBL:ENSG00000163513 TGFBR2

HGNC:11773 TGFBR2

KEGG Gene (Homo sapiens):7048 TGFBR2

Monarch:7048 TGFBR2

NCBI Gene:7048 TGFBR2

OMIM:190182 TGFBR2

UCSC:P37173 TGFBR2

Reference Transcript

Other Identifiers

0005720092

11724682_s_at

11750840_s_at

16938562

1814_at

1815_g_at

207334_PM_s_at

207334_s_at

208944_PM_at

208944_at

2615378

2615379

2615380

2615384

2615393

2615395

2615396

2615401

2615402

2615403

2615410

2615412

2615413

2615414

2615415

2615423

7048

8078350

A_14_P126005

A_23_P211957

A_23_P337242

D50683_at

GE57247

GE578892

GO:0000003

GO:0000166

GO:0001568

GO:0001569

GO:0001570

GO:0001666

GO:0001701

GO:0001947

GO:0002053

GO:0002088

GO:0002376

GO:0002651

GO:0002663

GO:0002666

GO:0003148

GO:0003149

GO:0003151

GO:0003181

GO:0003186

GO:0003214

GO:0003274

GO:0003417

GO:0003430

GO:0003674

GO:0004672

GO:0004674

GO:0004675

GO:0005024

GO:0005026

GO:0005515

GO:0005524

GO:0005539

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0005887

GO:0005901

GO:0006464

GO:0006468

GO:0006810

GO:0006898

GO:0006915

GO:0006950

GO:0007155

GO:0007165

GO:0007178

GO:0007179

GO:0007182

GO:0007219

GO:0007224

GO:0007369

GO:0007420

GO:0007507

GO:0007566

GO:0007568

GO:0007584

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008285

GO:0009410

GO:0009612

GO:0009749

GO:0009790

GO:0009887

GO:0009897

GO:0009986

GO:0010033

GO:0010468

GO:0010634

GO:0010718

GO:0010862

GO:0014070

GO:0016020

GO:0016021

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0017002

GO:0018105

GO:0018107

GO:0019899

GO:0030154

GO:0030324

GO:0031100

GO:0031435

GO:0032147

GO:0032924

GO:0032991

GO:0034713

GO:0034714

GO:0035162

GO:0038023

GO:0040007

GO:0040008

GO:0040011

GO:0042060

GO:0042127

GO:0043011

GO:0043167

GO:0043235

GO:0043415

GO:0043627

GO:0045121

GO:0045766

GO:0046332

GO:0046872

GO:0048185

GO:0048545

GO:0048565

GO:0048646

GO:0048661

GO:0048701

GO:0048856

GO:0048870

GO:0050431

GO:0051138

GO:0051216

GO:0051239

GO:0060044

GO:0060389

GO:0060412

GO:0060425

GO:0060433

GO:0060434

GO:0060439

GO:0060440

GO:0060443

GO:0060463

GO:0062009

GO:0070021

GO:0070723

GO:0071363

GO:1905007

GO:1905317

GO:1990086

GO:1990428

GO:2000379

GO:2000563

HMNXSV003024864

ILMN_1726245

ILMN_1744862

ILMN_2384241

PH_hs_0004687

TC03000149.hg

TC03002268.hg

g1827474_3p_at

g4507468_3p_a_at

Participates

as a component of

as an input of

Other forms of this molecule

TGFBR2 Y470D [plasma membrane]

TGFBR2 E526Q [plasma membrane]

TGFBR2 D522N [plasma membrane]

TGFBR2 R528H [plasma membrane]

TGFBR2 R528C [plasma membrane]

TGFBR2 K128fs*3 [cytosol]

TGFBR2 K128fs*35 [cytosol]

NEDD8-K556,K567-TGFBR2 [plasma membrane]

Inferred To

tgfbr2 [plasma membrane] (Xenopus tropicalis)

Tgfbr2 [plasma membrane] (Mus musculus)

Tgfbr2 [plasma membrane] (Rattus norvegicus)

put [plasma membrane] (Drosophila melanogaster)

tgfbr2b [plasma membrane] (Danio rerio)

TGFBR2 [plasma membrane] (Bos taurus)

TGFBR2 [plasma membrane] (Canis familiaris)

TGFBR2 [plasma membrane] (Gallus gallus)

TGFBR2 [plasma membrane] (Sus scrofa)

Ghost homologue of TGFBR2 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001020018.1, NP_003233.4

ZINC - World Drugs

TGFR2_HUMAN

Guide to Pharmacology - Targets

1795

OpenTargets

ENSG00000163513

ZINC - FDA approved

TGFR2_HUMAN

ZINC - Substances

TGFR2_HUMAN

ZINC - Biogenic

TGFR2_HUMAN

ZINC target

P37173

PRO

P37173

PDB

1M9Z, 3KFD, 1KTZ, 5E8Y, 1PLO, 4XJJ, 5E91, 5TY4, 5TX4, 2PJY, 5E92, 5QIN, 5E8V, 7DV6, 4P7U

ZINC - Investigational

TGFR2_HUMAN

HPA

ENSG00000163513-TGFBR2

GeneCards

P37173

Ensembl

ENST00000295754, ENSG00000163513, ENST00000359013, ENSP00000351905, ENSP00000295754

Pharos - Targets

P37173

Orphanet

15611

ZINC - Predictions - Purchasable

TGFR2_HUMAN

HMDB Protein

HMDBP01237

Interactors (75)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.811	6
UniProt:P10600 TGFB3	3	TGFB3 [platelet alpha granule lumen] (R-HSA-65942) TGFB3(21-300) [extracellular region] (R-HSA-2395290) TGFB3 [extracellular region] (R-HSA-114707)	0.765	8
UniProt:Q8IX30 SCUBE3	3	SCUBE3(?-993) [plasma membrane] (R-HSA-8943967) SCUBE3(21-?) [plasma membrane] (R-HSA-8943978) SCUBE3 [plasma membrane] (R-HSA-8943884)	0.632	6
UniProt:P09471 GNAO1	1	GNAO1 [plasma membrane] (R-HSA-2997536)	0.556	3
UniProt:P15036 ETS2	2	p-T72-ETS2 [nucleoplasm] (R-HSA-3132735) ETS2 [nucleoplasm] (R-HSA-1629811)	0.556	3
UniProt:Q99435-2 NELL2			0.556	3
UniProt:Q969W3 F104A			0.556	3
UniProt:Q3SY56 SP6			0.556	3
UniProt:Q8NCS7 SLC44A5	1	SLC44A5 [plasma membrane] (R-HSA-444459)	0.556	3
UniProt:Q96BQ3 TRI43			0.556	3
UniProt:O14531 DPYSL4	3	p-Y-DPYSL4 [cytosol] (R-HSA-399794) DPYSL4 [cytosol] (R-HSA-398126) p-S544-DPYSL4 [cytosol] (R-HSA-399808)	0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:Q9UMR2 DD19B			0.556	3
UniProt:Q9UHP3 USP25	1	USP25 [cytosol] (R-HSA-5696900)	0.556	3
UniProt:P46977 STT3A	1	STT3A [endoplasmic reticulum membrane] (R-HSA-265023)	0.556	3
UniProt:P06756 ITGAV	3	ITGAV(31-1048) [specific granule membrane] (R-HSA-6806145) ITGAV(31-1048) [phagocytic vesicle] (R-HSA-1236773) ITGAV(31-1048) [plasma membrane] (R-HSA-210013)	0.556	3
UniProt:Q8TAB5 CA216			0.556	3
UniProt:P49184 DNASE1L1	2	DNASE1L1 [specific granule lumen] (R-HSA-6799554) DNASE1L1 [extracellular region] (R-HSA-6806320)	0.556	3
UniProt:Q6NTF9-3 Q6NTF93			0.556	3
UniProt:P26378-2 P263782			0.556	3
UniProt:Q96NA2 RILP	1	RILP [lysosomal membrane] (R-HSA-2213229)	0.556	3
UniProt:Q9BZ95-3 Q9BZ953			0.556	3
UniProt:Q93084-2 Q930842			0.556	3
UniProt:P61966-2 AP1S1			0.556	3
UniProt:Q8NE08 Q8NE08			0.556	3
UniProt:Q4VBR4 Q4VBR4			0.556	3
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.556	3
UniProt:Q16560-2 SNRNP35			0.556	3
UniProt:P54819 AK2	1	AK2 [mitochondrial intermembrane space] (R-HSA-57822)	0.556	3
UniProt:P19544-6 WT1			0.556	3
UniProt:O75874 IDH1	10	IDH1 R132H mutant [cytosol] (R-HSA-880015) IDH1 R132L mutant [cytosol] (R-HSA-880000) IDH1 R132S mutant [cytosol] (R-HSA-880048) IDH1 R132C mutant [cytosol] (R-HSA-880031) IDH1 [tertiary granule lumen] (R-HSA-6800163) IDH1 [secretory granule lumen] (R-HSA-6800980) IDH1 [extracellular region] (R-HSA-6806433) IDH1 [ficolin-1-rich granule lumen] (R-HSA-6800977) IDH1 [cytosol] (R-HSA-389549) IDH1 [peroxisomal matrix] (R-HSA-389546)	0.556	3
UniProt:Q6PI98 INO80C	1	INO80C [nucleoplasm] (R-HSA-5689605)	0.556	3
UniProt:Q8TBE0 BAHD1			0.556	3
UniProt:P23276 KEL	1	KEL [plasma membrane] (R-HSA-5694121)	0.556	3
UniProt:Q9NP61 ARFGAP3	1	ARFGAP3 [cytosol] (R-HSA-6807740)	0.556	3
UniProt:Q8NC51 PAIRB			0.556	3
UniProt:P52756 RBM5	1	RBM5 [nucleoplasm] (R-HSA-72049)	0.556	3
UniProt:Q8TAT6 NPLOC4	2	NPLOC4 [nucleoplasm] (R-HSA-5654987) NPLOC4 [cytosol] (R-HSA-9755492)	0.556	3
UniProt:Q9Y228 T3JAM			0.556	3
UniProt:O75143-2 O751432			0.556	3
UniProt:Q14728 MFS10			0.556	3
UniProt:P54253 ATX1			0.556	3
UniProt:Q96IY1 NSL1	1	NSL1 [cytosol] (R-HSA-375309)	0.556	3
UniProt:Q16549 PCSK7			0.556	3
UniProt:Q16586 SGCA			0.556	3
UniProt:Q99720-4 SIGMAR1			0.556	3
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.556	3
IntAct:EBI-25836632 CCSB			0.556	3
UniProt:Q7Z614-3 SNX20			0.556	3
UniProt:Q13428-5 TCOF1			0.556	3
UniProt:Q13702-2 Q137022			0.556	3
UniProt:Q8TBJ4 PLPPR1	1	LPPR1 [plasma membrane] (R-HSA-6797625)	0.556	3
IntAct:EBI-25833683 CCSB			0.556	3
UniProt:P51674 GPM6A			0.556	3
UniProt:Q13200 PSMD2	5	PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.556	3
UniProt:Q9NPC7 MYNN			0.556	3
UniProt:Q8N448 LNX2			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9ULR0 ISY1	1	ISY1 [nucleoplasm] (R-HSA-6781963)	0.556	3
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.556	3
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.556	3
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.556	3
UniProt:O60259 KLK8	3	proKLK8 [extracellular region] (R-HSA-8850832) KLK8 [extracellular region] (R-HSA-8850833) KLK8 propeptide [extracellular region] (R-HSA-8850829)	0.556	3
UniProt:Q07869 PPARA	2	monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099) PPARA [nucleoplasm] (R-HSA-400186)	0.556	3
UniProt:Q9NUD9 PIGV	1	PIGV [endoplasmic reticulum membrane] (R-HSA-162739)	0.556	3
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.556	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.556	3
UniProt:Q96E93 KLRG1	1	KLRG1 [plasma membrane] (R-HSA-198006)	0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:P21246 PTN	1	PTN [extracellular region] (R-HSA-201500)	0.556	3
UniProt:P07200	7	TGFB1 [platelet alpha granule lumen] (R-SSC-65936) TGFB1 [plasma membrane] (R-SSC-5146781) TGFB1 [Golgi lumen] (R-SSC-114705) TGFB1 [Golgi lumen] (R-SSC-177108) TGFB1 [Golgi lumen] (R-SSC-9736812) TGFB1 [extracellular region] (R-SSC-2395367) TGFB1 [extracellular region] (R-SSC-170838)	0.525	2
UniProt:Q93074 MED12	1	MED12 [nucleoplasm] (R-HSA-212343)	0.524	3
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.508	2
UniProt:A2AGH6 Med12	2	Mediator of RNA polymerase II transcription subunit 12 [nucleoplasm] (R-MMU-556777) Med12 [nucleoplasm] (R-MMU-212343)	0.471	3
UniProt:Q9BYF1 ACE2	5	ACE2(18-805) [plasma membrane] (R-HSA-2022344) ACE2 [endoplasmic reticulum lumen] (R-HSA-9683474) glycosylated-ACE2 [endocytic vesicle membrane] (R-HSA-9686721) ACE2 [endocytic vesicle membrane] (R-HSA-9698958) glycosylated-ACE2 [plasma membrane] (R-HSA-9683480)	0.463	2

Cite Us!