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FRS2 [plasma membrane]
Stable Identifier
R-HSA-170963
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
FRS2-alpha
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
RET signaling (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
ALK fusions bind FRS (Homo sapiens)
ALK fusions:FRS [cytosol] (Homo sapiens)
FRS2,3 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
FRS2,3 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
ALK fusions phosphorylate FRS (Homo sapiens)
ALK fusions:FRS [cytosol] (Homo sapiens)
FRS2,3 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR1 in disease (Homo sapiens)
Activated FGFR1 mutants bind FRS2 (Homo sapiens)
Activated FGFR1 mutants:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants phosphorylate FRS2 (Homo sapiens)
Activated FGFR1 mutants:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Signaling by FGFR2 in disease (Homo sapiens)
Activated FGFR2 mutants bind FRS2 (Homo sapiens)
Activated FGFR2 mutants:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants phosphorylate FRS2 (Homo sapiens)
Activated FGFR2 mutants:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Signaling by FGFR3 in disease (Homo sapiens)
Activated FGFR3 point, translocation and fusion mutants bind FRS2 (Homo sapiens)
Activated FGFR3 point, translocation and fusion mutants:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2 (Homo sapiens)
Activated FGFR3 point, translocation and fusion mutants:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Signaling by FGFR4 in disease (Homo sapiens)
Activated FGFR4 mutants bind FRS2 (Homo sapiens)
Activated FGFR4 mutants:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants phosphorylate FRS2 (Homo sapiens)
Activated FGFR4 mutants:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Downstream signaling of activated FGFR1 (Homo sapiens)
FRS-mediated FGFR1 signaling (Homo sapiens)
Activated FGFR1 binds FRS2 (Homo sapiens)
Activated FGFR1:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 phosphorylates FRS2 (Homo sapiens)
Activated FGFR1:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Negative regulation of FGFR1 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 (Homo sapiens)
Activated FGFR1:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Signaling by FGFR2 (Homo sapiens)
Downstream signaling of activated FGFR2 (Homo sapiens)
FRS-mediated FGFR2 signaling (Homo sapiens)
Activated FGFR2 binds FRS2 (Homo sapiens)
Activated FGFR2:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 phosphorylates FRS2 (Homo sapiens)
Activated FGFR2:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Negative regulation of FGFR2 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Homo sapiens)
Activated FGFR2:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Signaling by FGFR3 (Homo sapiens)
Downstream signaling of activated FGFR3 (Homo sapiens)
FRS-mediated FGFR3 signaling (Homo sapiens)
Activated FGFR3 binds FRS2 (Homo sapiens)
Activated FGFR3:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR3 phosphorylates FRS2 (Homo sapiens)
Activated FGFR3:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Negative regulation of FGFR3 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2 (Homo sapiens)
Activated FGFR3:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
FRS-mediated FGFR4 signaling (Homo sapiens)
Activated FGFR4 binds FRS2 (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates FRS2 (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Negative regulation of FGFR4 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RND1 GTPase cycle (Homo sapiens)
RND1 binds effectors (Homo sapiens)
RND1 effectors [cytosol] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
RND1:GTP:RND1 effectors [plasma membrane] (Homo sapiens)
RND1 effectors [cytosol] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
RND2 GTPase cycle (Homo sapiens)
RND2 binds effectors (Homo sapiens)
RND2 effectors [cytosol] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
RND2:GTP:RND2 effectors [plasma membrane] (Homo sapiens)
RND2 effectors [cytosol] (Homo sapiens)
FRS2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WU20 FRS2
Gene Names
FRS2
Chain
initiator methionine:, chain:2-508
Reference Genes
BioGPS Gene:10818 FRS2
COSMIC (genes):FRS2 FRS2
CTD Gene:10818 FRS2
dbSNP Gene:10818 FRS2
ENSEMBL:ENSG00000166225 FRS2
HGNC:16971 FRS2
KEGG:hsa:10818 FRS2
Monarch:10818 FRS2
NCBI Gene:10818 FRS2
OMIM:607743 FRS2
UCSC:Q8WU20 FRS2
Reference Transcript
RefSeq:NM_001278357.1 FRS2
RefSeq:XM_017018718.1 FRS2
RefSeq:NM_001278354.1 FRS2
RefSeq:NM_001278355.1 FRS2
RefSeq:NM_001278351.1 FRS2
RefSeq:XM_017018717.1 FRS2
RefSeq:NM_001278353.1 FRS2
RefSeq:NM_001042555.2 FRS2
RefSeq:NM_006654.4 FRS2
RefSeq:XM_017018719.1 FRS2
RefSeq:NM_001278356.1 FRS2
Other Identifiers
10818
11743789_a_at
11743790_a_at
11743791_s_at
11750929_a_at
16753943
221308_PM_at
221308_at
226045_PM_at
226045_at
238486_PM_at
238486_at
3421580
3421584
3421599
3421600
3421601
3421604
3421609
3421614
3421615
3421616
3421617
3421618
3421619
3421620
3421621
3421622
3421623
3421624
3421625
3421626
3421627
3421628
3421629
50853_at
63302_at
69396_at
69399_g_at
69401_at
7957043
A_14_P139031
A_23_P430785
A_33_P3364112
GE61785
GE79952
GO:0001702
GO:0001759
GO:0002088
GO:0003281
GO:0005068
GO:0005104
GO:0005168
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0005912
GO:0007169
GO:0007185
GO:0007186
GO:0007405
GO:0008543
GO:0008595
GO:0012505
GO:0016020
GO:0019211
GO:0022414
GO:0030900
GO:0042981
GO:0043410
GO:0044344
GO:0046619
GO:0048856
GO:0050678
GO:0060090
GO:0060527
GO:0070307
GO:0070372
GO:0098772
GO:1904707
GO:2000726
HMNXSV003042492
Hs.202404.0.A1_3p_at
Hs.283705.0.A1_3p_at
ILMN_1703222
ILMN_1911605
ILMN_2254562
ILMN_2335893
PH_hs_0023008
PH_hs_0036448
TC12000614.hg
g5730056_3p_at
Participates
as a member of
RND2 effectors [cytosol] (Homo sapiens)
RND1 effectors [cytosol] (Homo sapiens)
FRS2,3 [plasma membrane] (Homo sapiens)
as a component of
Activated FGFR4 mutants:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR3 point, translocation and fusion mutants:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants:FRS2 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR3:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR2:FRS2 [plasma membrane] (Homo sapiens)
as an input of
Activated FGFR4 mutants bind FRS2 (Homo sapiens)
Activated FGFR2 mutants bind FRS2 (Homo sapiens)
Activated FGFR3 point, translocation and fusion mutants bind FRS2 (Homo sapiens)
Activated FGFR1 mutants bind FRS2 (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Homo sapiens)
Activated FGFR4 binds FRS2 (Homo sapiens)
Activated FGFR1 binds FRS2 (Homo sapiens)
Activated FGFR3 binds FRS2 (Homo sapiens)
Activated FGFR2 binds FRS2 (Homo sapiens)
Other forms of this molecule
p-6Y-FRS2 [plasma membrane]
p-8T-FRS2 [plasma membrane]
p-6Y-FRS2 [cytosol]
FRS2 [cytosol]
p-Y-FRS2 [cytosol]
Inferred To
Dmel\CG13398 [plasma membrane]
(Drosophila melanogaster)
Frs2 [plasma membrane]
(Mus musculus)
Frs2 [plasma membrane]
(Rattus norvegicus)
Ghost homologue of FRS2 [plasma membrane]
(Caenorhabditis elegans)
Ghost homologue of FRS2 [plasma membrane]
(Danio rerio)
FRS2 [plasma membrane]
(Bos taurus)
FRS2 [plasma membrane]
(Canis familiaris)
FRS2 [plasma membrane]
(Gallus gallus)
FRS2 [plasma membrane]
(Sus scrofa)
frs2 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001265280.1
,
NP_001265282.1
,
NP_001036020.1
,
NP_001265283.1
,
NP_001265284.1
,
NP_001265285.1
,
XP_016874208.1
,
NP_001265286.1
,
XP_016874206.1
,
XP_016874207.1
,
NP_006645.3
OpenTargets
ENSG00000166225
ENSEMBL
ENSP00000381083
,
ENST00000550389
,
ENST00000549921
,
ENSP00000450048
,
ENST00000397997
,
ENSP00000447241
HPA
ENSG00000166225-FRS2
PRO
Q8WU20
Pharos - Targets
Q8WU20
GlyGen
Q8WU20
PDB
1XR0
,
2MFQ
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q06124 PTPN11
4
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
PTPN11 [cytosol]
(R-HSA-162563)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
0.649
4
UniProt:P11362 FGFR1
9
FGFR1 [plasma membrane]
(R-HSA-9756433)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
0.569
3
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