FRS2 binds to active TrkA receptor

Stable Identifier
R-HSA-170964
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endosome membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FRS2 binds to active TrkA receptor
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
FRS2 binds to TRKA through the same motif (NPXY) around the TRKA phospho-tyrosine residue Y496 to which SHC proteins bind. The competition between SHC proteins and FRS2 for binding to NGF-activated TRKA may provide a novel mechanism by which proliferation and differentiation may be regulated in response to neurotrophin stimulation. Tyrosine phosphorylation of FRS2 occurs within 2 min of NGF stimulation.
Literature References
PubMed ID Title Journal Year
10629055 FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

Laks, S, Schlessinger, J, Ong, SH, Lax, I, Gotoh, N, Hadari, YR, Guy, GR

Mol Cell Biol 2000
Participants
Input
Output
Participates
as an event of
Orthologous Events
FRS2 binds to active TrkA receptor (Bos taurus)
FRS2 binds to active TrkA receptor (Canis familiaris)
FRS2 binds to active TrkA receptor (Gallus gallus)
FRS2 binds to active TrkA receptor (Mus musculus)
FRS2 binds to active TrkA receptor (Rattus norvegicus)
FRS2 binds to active TrkA receptor (Sus scrofa)
FRS2 binds to active TrkA receptor (Xenopus tropicalis)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2006-01-25)
Cite Us!