Reactome | RALGDS [cytosol]

RALGDS [cytosol]

Stable Identifier

R-HSA-171001

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RalGDS, Guanine-nucleotide releasing factor

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q12967 RALGDS

Gene Names

RALGDS, KIAA1308, RGF

Chain

chain:1-914

Reference Genes

BioGPS Gene:5900 RALGDS

COSMIC (genes):RALGDS RALGDS

CTD Gene:5900 RALGDS

dbSNP Gene:5900 RALGDS

ENSEMBL:ENSG00000160271 RALGDS

HGNC:9842 RALGDS

KEGG:hsa:5900 RALGDS

Monarch:5900 RALGDS

NCBI Gene:5900 RALGDS

OMIM:601619 RALGDS

UCSC:Q12967 RALGDS

Reference Transcript

Participates

as an input of

Ral-GDS binds to Ras-GTP (Homo sapiens)

as a component of

Ras-GTP:RalGDS complex [plasma membrane] (Homo sapiens)

as a member of

RAL GDS proteins [cytosol] (Homo sapiens)

Inferred To

gefA [cytosol] (Dictyostelium discoideum)

gefS [cytosol] (Dictyostelium discoideum)

gefJ [cytosol] (Dictyostelium discoideum)

gefH [cytosol] (Dictyostelium discoideum)

rgl-1 [cytosol] (Caenorhabditis elegans)

gefD [cytosol] (Dictyostelium discoideum)

gefM [cytosol] (Dictyostelium discoideum)

gefF [cytosol] (Dictyostelium discoideum)

gefK [cytosol] (Dictyostelium discoideum)

ralgds [cytosol] (Xenopus tropicalis)

Ralgds [cytosol] (Mus musculus)

Ralgds [cytosol] (Rattus norvegicus)

gefR [cytosol] (Dictyostelium discoideum)

gefI [cytosol] (Dictyostelium discoideum)

gefB [cytosol] (Dictyostelium discoideum)

Rgl [cytosol] (Drosophila melanogaster)

gefY [cytosol] (Dictyostelium discoideum)

RALGDS [cytosol] (Bos taurus)

RALGDS [cytosol] (Canis familiaris)

RALGDS [cytosol] (Dictyostelium discoideum)

RALGDS [cytosol] (Gallus gallus)

RALGDS [cytosol] (Sus scrofa)

gefN [cytosol] (Dictyostelium discoideum)

gefE [cytosol] (Dictyostelium discoideum)

gefV [cytosol] (Dictyostelium discoideum)

gefAA [cytosol] (Dictyostelium discoideum)

Homologues of RALGDS [cytosol] (Dictyostelium discoideum)

gefG [cytosol] (Dictyostelium discoideum)

gefL [cytosol] (Dictyostelium discoideum)

gefQ [cytosol] (Dictyostelium discoideum)

gflD [cytosol] (Dictyostelium discoideum)

Cross References

ENSEMBL

ENST00000393160, ENSP00000376864, ENSG00000160271, ENSP00000361120, ENST00000393157, ENSP00000361132, ENST00000372050, ENST00000372062, ENSP00000361117, ENST00000372047, ENSP00000376867

OpenTargets

ENSG00000160271

GeneCards

RALGDS

HPA

ENSG00000160271-RALGDS

PRO

Q12967

Pharos - Targets

Q12967

GlyGen

Q12967

HMDB Protein

HMDBP08430

PDB

3KH0, 2B3A, 2RGF, 1RAX

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) HRAS [plasma membrane] (R-HSA-62717) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) proHRAS [cytosol] (R-HSA-9647765) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.683	3
UniProt:P61224 RAP1B	2	RAP1B [plasma membrane] (R-HSA-377590) RAP1B [azurophil granule membrane] (R-HSA-6804972)	0.573	2

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