Reactome | RALGDS [cytosol]

RALGDS [cytosol]

Stable Identifier

R-HSA-171001

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RalGDS, Guanine-nucleotide releasing factor

Locations in the PathwayBrowser for interactor UniProt:P01112%20HRAS

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Signalling to ERKs (Homo sapiens)
        
        Signalling to RAS (Homo sapiens)
        
        p38MAPK events (Homo sapiens)
        
        Ral-GDS binds to Ras-GTP (Homo sapiens)
        
        RALGDS [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q12967 RALGDS

Gene Names

RALGDS, KIAA1308, RGF

Chain

chain:1-914

Reference Genes

BioGPS Gene:5900 RALGDS

COSMIC (genes):RALGDS RALGDS

CTD Gene:5900 RALGDS

dbSNP Gene:5900 RALGDS

ENSEMBL:ENSG00000160271 RALGDS

ENSEMBL_homo_sapiens_GENE:ENSG00000160271.16 RALGDS

HGNC:9842 RALGDS

KEGG Gene (Homo sapiens):5900 RALGDS

Monarch:5900 RALGDS

NCBI Gene:5900 RALGDS

OMIM:601619 RALGDS

UCSC:Q12967 RALGDS

Reference Transcript

Other Identifiers

11737952_a_at

11741359_a_at

11741360_x_at

11752122_a_at

11757908_x_at

17099403

209050_PM_s_at

209050_s_at

209051_PM_s_at

209051_s_at

3228464

3228465

3228471

3228475

3228477

3228479

3228480

3228481

3228484

3228485

3228487

3228488

3228489

3228490

3228491

3228492

3228493

3228495

3228497

3228498

3228500

3228501

3228509

3228510

3228516

3228517

3228518

3228522

34254_at

5900

8164810

91384_at

GE503857

GO:0005085

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0005903

GO:0007165

GO:0007264

GO:0007265

GO:0023052

GO:0030695

GO:0043226

GO:0098772

HMNXSV003048189

Hs.106185.0.S2_3p_a_at

ILMN_1699856

ILMN_2297961

PH_hs_0005909

TC09002922.hg

U14417_at

g9931301_3p_a_at

Participates

as a component of

Ras-GTP:RalGDS complex [plasma membrane] (Homo sapiens)

as an input of

Ral-GDS binds to Ras-GTP (Homo sapiens)

as a member of

RAL GDS proteins [cytosol] (Homo sapiens)

Inferred To

gefA [cytosol] (Dictyostelium discoideum)

gefS [cytosol] (Dictyostelium discoideum)

gefJ [cytosol] (Dictyostelium discoideum)

gefH [cytosol] (Dictyostelium discoideum)

rgl-1 [cytosol] (Caenorhabditis elegans)

gefD [cytosol] (Dictyostelium discoideum)

gefM [cytosol] (Dictyostelium discoideum)

gefF [cytosol] (Dictyostelium discoideum)

gefK [cytosol] (Dictyostelium discoideum)

ralgds [cytosol] (Xenopus tropicalis)

Ralgds [cytosol] (Mus musculus)

Ralgds [cytosol] (Rattus norvegicus)

gefR [cytosol] (Dictyostelium discoideum)

gefI [cytosol] (Dictyostelium discoideum)

gefB [cytosol] (Dictyostelium discoideum)

Rgl [cytosol] (Drosophila melanogaster)

gefY [cytosol] (Dictyostelium discoideum)

RALGDS [cytosol] (Bos taurus)

RALGDS [cytosol] (Canis familiaris)

RALGDS [cytosol] (Dictyostelium discoideum)

RALGDS [cytosol] (Gallus gallus)

RALGDS [cytosol] (Sus scrofa)

gefN [cytosol] (Dictyostelium discoideum)

gefE [cytosol] (Dictyostelium discoideum)

gefV [cytosol] (Dictyostelium discoideum)

gefAA [cytosol] (Dictyostelium discoideum)

Homologues of RALGDS [cytosol] (Dictyostelium discoideum)

gefG [cytosol] (Dictyostelium discoideum)

gefL [cytosol] (Dictyostelium discoideum)

gefQ [cytosol] (Dictyostelium discoideum)

gflD [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001035827.1, NP_001258703.1, NP_001258704.1, NP_006257.1, NP_001258705.1

OpenTargets

ENSG00000160271

GeneCards

Q12967

HPA

ENSG00000160271-RALGDS

Ensembl

ENST00000372047, ENSP00000361117, ENSP00000376864, ENST00000393157, ENST00000393160, ENSP00000376867, ENST00000372062, ENSP00000361132, ENST00000372050, ENSP00000361120, ENSG00000160271

PRO

Q12967

Pharos - Targets

Q12967

HMDB Protein

HMDBP08430

PDB

2RGF, 3KH0, 2B3A, 1RAX

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01112 HRAS	20	HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788)	0.683	3
UniProt:P61224 RAP1B	2	RAP1B [azurophil granule membrane] (R-HSA-6804972) RAP1B [plasma membrane] (R-HSA-377590)	0.573	2

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