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SMAD2,3 [cytosol]
Stable Identifier
R-HSA-171172
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Synonyms
R-SMAD2,3
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Signaling by NODAL (Homo sapiens)
Phosphorylation of R-SMAD2/3 by NODAL receptor (Homo sapiens)
SMAD2,3 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by TGF-beta Receptor Complex in Cancer (Homo sapiens)
Loss of Function of TGFBR1 in Cancer (Homo sapiens)
TGFBR1 KD Mutants in Cancer (Homo sapiens)
An anchoring protein ZFYVE9 (SARA) does not recruit SMAD2/3 to TGFB1:TGFBR2:p-TGFBR1 KD Mutants (Homo sapiens)
SMAD2,3 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
Dephosphorylated SMAD2/3 translocates to the cytosol (Homo sapiens)
SMAD2,3 [cytosol] (Homo sapiens)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Homo sapiens)
SMAD2,3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by Activin (Homo sapiens)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Homo sapiens)
SMAD2,3 [cytosol] (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Activated type I receptor phosphorylates SMAD2/3 directly (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Homo sapiens)
SMAD2,3 [cytosol] (Homo sapiens)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Homo sapiens)
SMAD2,3 [cytosol] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Homo sapiens)
SMAD2,3 [cytosol] (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
MTMR4 dephosphorylates SMAD2/3 (Homo sapiens)
SMAD2,3 [cytosol] (Homo sapiens)
PMEPA1 sequesters unphosphorylated SMAD2/3 (Homo sapiens)
SMAD2,3 [cytosol] (Homo sapiens)
SMAD2/3:PMEPA1 [plasma membrane] (Homo sapiens)
SMAD2,3 [cytosol] (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
Dephosphorylated SMAD2/3 translocates to the cytosol (Homo sapiens)
SMAD2,3 [cytosol] (Homo sapiens)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Homo sapiens)
SMAD2,3 [cytosol] (Homo sapiens)
Participants
members
SMAD2 [cytosol]
(Homo sapiens)
SMAD3 [cytosol]
(Homo sapiens)
Participates
as an input of
An anchoring protein ZFYVE9 (SARA) does not recruit SMAD2/3 to TGFB1:TGFBR2:p-TGFBR1 KD Mutants (Homo sapiens)
PMEPA1 sequesters unphosphorylated SMAD2/3 (Homo sapiens)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Homo sapiens)
Phosphorylation of R-SMAD2/3 by NODAL receptor (Homo sapiens)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Homo sapiens)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Homo sapiens)
as a component of
SMAD2/3:PMEPA1 [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Homo sapiens)
as an output of
MTMR4 dephosphorylates SMAD2/3 (Homo sapiens)
Dephosphorylated SMAD2/3 translocates to the cytosol (Homo sapiens)
Inferred To
Smox [cytosol]
(Drosophila melanogaster)
SMAD2,3 [cytosol]
(Bos taurus)
SMAD2,3 [cytosol]
(Canis familiaris)
SMAD2,3 [cytosol]
(Danio rerio)
SMAD2,3 [cytosol]
(Gallus gallus)
SMAD2,3 [cytosol]
(Mus musculus)
SMAD2,3 [cytosol]
(Rattus norvegicus)
SMAD2,3 [cytosol]
(Sus scrofa)
daf-8 [cytosol]
(Caenorhabditis elegans)
smad2 [cytosol]
(Xenopus tropicalis)
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