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p-2S-SMAD2,3 [cytosol]
Stable Identifier
R-HSA-171182
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S465,467-SMAD2,p-S423,425-SMAD3, Phospho-R-SMAD
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Signaling by NODAL (Homo sapiens)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
Phosphorylation of R-SMAD2/3 by NODAL receptor (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by TGF-beta Receptor Complex in Cancer (Homo sapiens)
Loss of Function of SMAD4 in Cancer (Homo sapiens)
SMAD4 MH2 Domain Mutants in Cancer (Homo sapiens)
SMAD4 MH2 Domain Mutants do not bind phosphorylated SMAD2 and SMAD3 (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by Activin (Homo sapiens)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Activated type I receptor phosphorylates SMAD2/3 directly (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
MTMR4 binds phosphorylated SMAD2/3 (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
MTMR4 dephosphorylates SMAD2/3 (Homo sapiens)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
PMEPA1 sequesters phosphorylated SMAD2/3 (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-2S-SMAD2/3:PMEPA1 [early endosome membrane] (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
Phosphorylated SMAD2/3 dissociates from TGFBR (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
Participants
members
p-S465,S467-SMAD2 [cytosol]
(Homo sapiens)
p-S423,S425-SMAD3 [cytosol]
(Homo sapiens)
Participates
as an input of
SMAD4 MH2 Domain Mutants do not bind phosphorylated SMAD2 and SMAD3 (Homo sapiens)
PMEPA1 sequesters phosphorylated SMAD2/3 (Homo sapiens)
MTMR4 binds phosphorylated SMAD2/3 (Homo sapiens)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Homo sapiens)
as a component of
p-2S-SMAD2/3:PMEPA1 [early endosome membrane] (Homo sapiens)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Homo sapiens)
as an output of
Phosphorylation of R-SMAD2/3 by NODAL receptor (Homo sapiens)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Homo sapiens)
Phosphorylated SMAD2/3 dissociates from TGFBR (Homo sapiens)
Inferred To
phospho-Smox [cytosol]
(Drosophila melanogaster)
p-2S-SMAD2,3 [cytosol]
(Bos taurus)
p-2S-SMAD2,3 [cytosol]
(Canis familiaris)
p-2S-SMAD2,3 [cytosol]
(Danio rerio)
p-2S-SMAD2,3 [cytosol]
(Gallus gallus)
p-2S-SMAD2,3 [cytosol]
(Mus musculus)
p-2S-SMAD2,3 [cytosol]
(Rattus norvegicus)
p-2S-SMAD2,3 [cytosol]
(Sus scrofa)
phospho-smad2 [cytosol]
(Xenopus tropicalis)
phospho-daf-8 [cytosol]
(Caenorhabditis elegans)
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