Reactome | CCR5 [plasma membrane]

CCR5 [plasma membrane]

Stable Identifier

R-HSA-171279

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

C-C chemokine receptor type 5

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Early Phase of HIV Life Cycle (Homo sapiens)
        
        Binding and entry of HIV virion (Homo sapiens)
        
        CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4 (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
        
        CD4:Env gp120:CCR5,CXCR4:complex [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Conformational changes in gp120 exposes gp41 (Homo sapiens)
        
        Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
        
        CD4:Env gp120:CCR5,CXCR4:complex [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Virion with gp41 exposed [extracellular region] (Homo sapiens)
        
        CCR5/CXCR4:CD4:Env gp120 (second conformation change) complex [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Fusion of viral membrane with host cell membrane (Homo sapiens)
        
        CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Fusogenic activation of gp41 (Homo sapiens)
        
        Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41 fusion peptide complex:CCR5 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Virion with gp41 exposed [extracellular region] (Homo sapiens)
        
        CCR5/CXCR4:CD4:Env gp120 (second conformation change) complex [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Insertion of gp41 fusion peptide into the target membrane (Homo sapiens)
        
        Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41 fusion peptide complex:CCR5 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41insertion complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        N and C terminal heptad repeat helices of gp41 form six-helix bundle (Homo sapiens)
        
        Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41insertion complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5, CCR1 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptors CCR3, 4 and 5 bind CCL5 ligand (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR5 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P51681 CCR5

Gene Names

CCR5, CMKBR5

Chain

chain:1-352

Reference Genes

BioGPS Gene:1234 CCR5

COSMIC (genes):CCR5 CCR5

CTD Gene:1234 CCR5

dbSNP Gene:1234 CCR5

ENSEMBL:ENSG00000160791 CCR5

ENSEMBL_homo_sapiens_GENE:ENSG00000160791.14 CCR5

HGNC:1606 CCR5

KEGG Gene (Homo sapiens):1234 CCR5

Monarch:1234 CCR5

NCBI Gene:1234 CCR5

OMIM:601373 CCR5

Reference Transcript

Other Identifiers

11730909_s_at

11730910_s_at

11748062_s_at

1234

16940182

206991_PM_s_at

206991_s_at

2620858

2620859

2620861

36724_s_at

4047176

4047177

4047179

8079401

8093298

A_23_P412321

GE80926

GO:0000165

GO:0001618

GO:0002376

GO:0002407

GO:0003779

GO:0003824

GO:0004435

GO:0004930

GO:0004950

GO:0005515

GO:0005737

GO:0005768

GO:0005886

GO:0006816

GO:0006935

GO:0006952

GO:0006954

GO:0006955

GO:0006968

GO:0007165

GO:0007166

GO:0007186

GO:0007204

GO:0007267

GO:0008092

GO:0009897

GO:0009986

GO:0012501

GO:0014808

GO:0015026

GO:0016020

GO:0016493

GO:0016787

GO:0019722

GO:0019957

GO:0023052

GO:0031410

GO:0042802

GO:0043226

GO:0046718

GO:0048870

GO:0055065

GO:0055085

GO:0060089

GO:0060326

GO:0070098

GO:0070723

GO:0071222

GO:0071791

GO:2000110

HMNXSV003029170

ILMN_1653395

ILMN_2145033

PH_hs_0031237

TC03002321.hg

U83326_s_at

U95626_rna3_at

X99393_s_at

g4502638_3p_a_at

Participates

as a member of

Inferred To

Ccr5 [plasma membrane] (Mus musculus)

Ccr5 [plasma membrane] (Rattus norvegicus)

CCR5 [plasma membrane] (Bos taurus)

CCR5 [plasma membrane] (Canis familiaris)

CCR5 [plasma membrane] (Gallus gallus)

CCR5 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001093638.1, NP_000570.1

ZINC - World Drugs

CCR5_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000160791

ZINC - FDA approved

CCR5_HUMAN

ZINC - Substances

CCR5_HUMAN

ZINC - Biogenic

CCR5_HUMAN

ZINC target

P51681

PRO

P51681

PDB

2L87, 7F1R, 6FGP, 5YD5, 5YD3, 4MBS, 2RLL, 7NW3, 5YY4, 7O7F, 7F1S, 6MEO, 7NJZ, 5YD4, 5UIW, 7F1Q, 2RRS, 6MET, 2MZX

ZINC - Investigational

CCR5_HUMAN

ZINC - Metabolites

CCR5_HUMAN

HPA

ENSG00000160791-CCR5

GeneCards

P51681

Ensembl

ENSG00000160791, ENSP00000292303, ENSP00000404881, ENST00000292303, ENST00000445772

Pharos - Targets

P51681

Orphanet

21759

ZINC - Predictions - Purchasable

CCR5_HUMAN

HMDB Protein

HMDBP07578

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61073 CXCR4	1	CXCR4 [plasma membrane] (R-HSA-2980772)	0.675	4
UniProt:P01730 CD4	4	CD4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869082) CD4 [early endosome] (R-HSA-182147) CD4 [endoplasmic reticulum membrane] (R-HSA-180575) CD4 [plasma membrane] (R-HSA-167542)	0.667	3
UniProt:P13501 CCL5	1	CCL5(24-91) [extracellular region] (R-HSA-373108)	0.656	6

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