Reactome | Cleavage of the viral Env gp160 precursor polyprotein

Cleavage of the viral Env gp160 precursor polyprotein

Stable Identifier

R-HSA-171288

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - HIV Infection (Homo sapiens)
    - HIV Life Cycle (Homo sapiens)
      - Late Phase of HIV Life Cycle (Homo sapiens)
        
        Assembly Of The HIV Virion (Homo sapiens)
        
        Synthesis and processing of ENV and VPU (Homo sapiens)
        
        Cleavage of the viral Env gp160 precursor polyprotein (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Cleavage of the viral Env gp160 precursor polyprotein

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The trimeric gp160 complexes are cleaved into the gp41 and gp120 subunits by the cellular protease furin.

Literature References

PubMed ID	Title	Journal	Year
8163529	The convertases furin and PC1 can both cleave the human immunodeficiency virus (HIV)-1 envelope glycoprotein gp160 into gp120 (HIV-1 SU) and gp41 (HIV-I TM) Kompelli, A, Jean, F, Ruysschaert, JM, Marshall, G, Cogniaux, J, Decroly, E, Basak, A, Howard, SC, Jacob, GS, Vandenbranden, M	J. Biol. Chem.	1994