Reactome | SKI [nucleoplasm]

SKI [nucleoplasm]

Stable Identifier

R-HSA-173473

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Ski oncogene

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P12755 SKI

Gene Names

SKI

Chain

chain:1-728

Reference Genes

BioGPS Gene:6497 SKI

COSMIC (genes):SKI SKI

CTD Gene:6497 SKI

dbSNP Gene:6497 SKI

ENSEMBL:ENSG00000157933 SKI

HGNC:10896 SKI

KEGG:hsa:6497 SKI

Monarch:6497 SKI

NCBI Gene:6497 SKI

OMIM:164780 SKI

UCSC:P12755 SKI

Reference Transcript

RefSeq:NM_003036.3 SKI

Other Identifiers

11734993_at

11734994_s_at

11734995_x_at

11734996_at

11734997_at

16657993

1918_at

204270_PM_at

204270_at

229265_PM_at

229265_at

2316386

2316387

2316388

2316389

2316390

2316391

2316392

2316393

2316394

2316401

2316449

2316450

2316451

2316452

2316453

2316454

2316455

2316456

2316457

2316458

2316459

2316460

2316461

2316462

2316463

2316464

2316465

2316466

2316467

2316469

2316470

2316472

2316474

2316476

2316477

41499_at

52776_at

6497

78059_at

7897068

A_14_P104756

A_23_P325631

A_24_P338603

A_24_P362100

GE80779

GO:0000122

GO:0000978

GO:0000981

GO:0001227

GO:0001843

GO:0002089

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005813

GO:0005815

GO:0006355

GO:0007179

GO:0008270

GO:0008285

GO:0009948

GO:0010626

GO:0014902

GO:0016604

GO:0016605

GO:0017053

GO:0019901

GO:0019904

GO:0021772

GO:0022011

GO:0030154

GO:0030177

GO:0030326

GO:0030512

GO:0030514

GO:0031625

GO:0032926

GO:0032991

GO:0035019

GO:0042802

GO:0043010

GO:0043226

GO:0043388

GO:0043585

GO:0045668

GO:0045944

GO:0046332

GO:0046811

GO:0048147

GO:0048593

GO:0048741

GO:0048856

GO:0048870

GO:0060021

GO:0060038

GO:0060041

GO:0060325

GO:0060349

GO:0060392

GO:0098772

GO:0140110

GO:0140297

HMNXSV003023017

Hs.2969.0.A2_3p_at

Hs.2969.1.S1_3p_at

ILMN_1710598

PH_hs_0027545

TC01000057.hg

X15218_at

Participates

as a component of

p-2S-SMAD1/5/8:SMAD4:SKI [nucleoplasm] (Homo sapiens)

as an input of

SKI complexes with the Smad complex, suppressing BMP2 signalling (Homo sapiens)

as a member of

SKI/SKIL [nucleoplasm] (Homo sapiens)

Inferred To

SKI [nucleoplasm] (Bos taurus)

SKI [nucleoplasm] (Canis familiaris)

SKI [nucleoplasm] (Gallus gallus)

SKI [nucleoplasm] (Sus scrofa)

skia [nucleoplasm] (Danio rerio)

Ski [nucleoplasm] (Mus musculus)

Ski [nucleoplasm] (Rattus norvegicus)

Snoo [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_003027.1

ENSEMBL

ENSP00000367797, ENST00000378536

OpenTargets

ENSG00000157933

HPA

ENSG00000157933-SKI

PRO

P12755

Pharos - Targets

P12755

GlyGen

P12755

Orphanet

SKI

HMDB Protein

HMDBP14460

PDB

1SBX, 1MR1, 6ZVQ, 5XOD

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.937	15
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009185) p-S465,S467-SMAD2 [cytosol] (R-HSA-3009186) SMAD2 [cytosol] (R-HSA-3006353) p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009189) Ub,p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-9773843) SMAD2 [nucleoplasm] (R-HSA-3006352) p-S250-SMAD2 [cytosol] (R-HSA-9731121) SMAD2 Q429* [cytosol] (R-HSA-9668727) SMAD2 S467P [cytosol] (R-HSA-3304375) SMAD2 L315* [cytosol] (R-HSA-9668725) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 S296* [cytosol] (R-HSA-9668729)	0.865	11
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.837	11
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.669	4
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.641	3
UniProt:Q9QUI1 LRA25			0.639	6
UniProt:Q60974 Ncor1	3	Ncor1 [cytosol] (R-MMU-1253324) Ncor1 [nucleoplasm] (R-MMU-442459) Ncor1 [nucleoplasm] (R-MMU-442501)	0.581	5
UniProt:Q9H871 RMND5A	1	RMND5A [cytosol] (R-HSA-9861580)	0.527	3
UniProt:SMAD7 ENSG00000101665			0.527	4
UniProt:P36941 LTBR	1	LTBR [plasma membrane] (R-HSA-5668750)	0.527	2
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.527	3
UniProt:Q6ZSG1 ARK2C			0.499	2
IntAct:EBI-4399559 UBIQ			0.499	2
UniProt:O14744 PRMT5	3	PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609) p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300)	0.462	3
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.462	2
UniProt:Q9BZK7 TBL1XR1	1	TBL1XR1 [nucleoplasm] (R-HSA-351643)	0.462	2

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