SMURF2 ubiquitinates SMAD2

Stable Identifier
R-HSA-173542
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SMURF2 ubiquitinates SMAD2
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SMAD2 is polyubiquitinated by SMURF2 and targeted for proteasome-mediated degradation.

Literature References
PubMed ID Title Journal Year
11158580 Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

Zhang, Y, Gehling, DJ, Chang, C, Hemmati-Brivanlou, A, Derynck, R

Proc Natl Acad Sci U S A 2001
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Output
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Catalyst Activity

ubiquitin-protein transferase activity of SMAD2:SMURF2 [cytosol]

Physical Entity
SMAD2:SMURF2 [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
SMURF2 ubiquitinates SMAD2 (Bos taurus)
SMURF2 ubiquitinates SMAD2 (Canis familiaris)
SMURF2 ubiquitinates SMAD2 (Danio rerio)
SMURF2 ubiquitinates SMAD2 (Drosophila melanogaster)
SMURF2 ubiquitinates SMAD2 (Gallus gallus)
SMURF2 ubiquitinates SMAD2 (Mus musculus)
SMURF2 ubiquitinates SMAD2 (Rattus norvegicus)
SMURF2 ubiquitinates SMAD2 (Sus scrofa)
SMURF2 ubiquitinates SMAD2 (Xenopus tropicalis)
Authored
Jassal, B  (2006-02-02)
Huminiecki, L  (2006-02-02)
Moustakas, A  (2006-02-02)
Heldin, CH  (2006-02-02)
Reviewed
Huang, T  (2012-05-14)
Heldin, CH  (2006-04-18)
Created
Jassal, B  (2006-02-14)
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