APC/C:Cdc20 mediated degradation of Cyclin B

Stable Identifier
R-HSA-174048
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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APC/C:Cdc20 mediated degradation of Cyclin B
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The degradation of cyclin B1, which appears to occur at the mitotic spindle, is delayed until the metaphase /anaphase transition by the spindle assembly checkpoint and is required in order for sister chromatids to separate (Geley et al. 2001;Hagting et al, 2002).
Literature References
PubMed ID Title Journal Year
11285280 Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint

Peters, JM, Gannon, J, Geley, S, Kramer, E, Gieffers, C, Hunt, T

J Cell Biol 2001
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
anaphase-promoting complex-dependent catabolic process (0031145)
Orthologous Events
APC/C:Cdc20 mediated degradation of Cyclin B (Bos taurus)
APC/C:Cdc20 mediated degradation of Cyclin B (Canis familiaris)
APC/C:Cdc20 mediated degradation of Cyclin B (Dictyostelium discoideum)
APC/C:Cdc20 mediated degradation of Cyclin B (Drosophila melanogaster)
APC/C:Cdc20 mediated degradation of Cyclin B (Gallus gallus)
APC/C:Cdc20 mediated degradation of Cyclin B (Mus musculus)
APC/C:Cdc20 mediated degradation of Cyclin B (Rattus norvegicus)
APC/C:Cdc20 mediated degradation of Cyclin B (Sus scrofa)
APC/C:Cdc20 mediated degradation of Cyclin B (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Castro, A  (2006-01-26)
Lorca, T  (2006-01-26)
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-02-17)
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