Multiubiquitination of APC/C-associated Cdh1

Stable Identifier
R-HSA-174057
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Multiubiquitination of APC/C-associated Cdh1
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Cdh1 is multiubiquitinated by the APC/C:Cdh1 complex prior to degradation by the 26S proteasome.
Literature References
PubMed ID Title Journal Year
15029244 Mammalian Cdh1/Fzr mediates its own degradation

Listovsky, T, Oren, YS, Yudkovsky, Y, Mahbubani, HM, Weiss, AM, Lebendiker, M, Brandeis, M

EMBO J 2004
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
ubiquitin-dependent protein catabolic process (0006511)
Catalyst Activity

ubiquitin-protein transferase activity of phospho-Cdh1:phospho-APC/C complex [nucleoplasm]

Physical Entity
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
Multiubiquitination of APC/C-associated Cdh1 (Bos taurus)
Multiubiquitination of APC/C-associated Cdh1 (Canis familiaris)
Multiubiquitination of APC/C-associated Cdh1 (Dictyostelium discoideum)
Multiubiquitination of APC/C-associated Cdh1 (Drosophila melanogaster)
Multiubiquitination of APC/C-associated Cdh1 (Gallus gallus)
Multiubiquitination of APC/C-associated Cdh1 (Mus musculus)
Multiubiquitination of APC/C-associated Cdh1 (Rattus norvegicus)
Multiubiquitination of APC/C-associated Cdh1 (Sus scrofa)
Multiubiquitination of APC/C-associated Cdh1 (Xenopus tropicalis)
Authored
Lorca, T  (2006-01-26)
Castro, A  (2006-01-26)
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-02-17)
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