Reactome | Phosphorylation of Cdh1 by Cyclin A:Cdk2

Phosphorylation of Cdh1 by Cyclin A:Cdk2

Stable Identifier

R-HSA-174079

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Phosphorylation of Cdh1 by Cyclin A:Cdk2

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At the G1/S transition, the Cdh1 subunit of the APC:Cdh1 complex is phosphorylated by Cyclin A:Cdk2 and dissociates from APC/C. This inactivates APC/C and permits the accumulation of cell cycle proteins required for DNA synthesis and entry into mitosis.

Literature References

PubMed ID	Title	Journal	Year
10548110	Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex Lukas, J, Lindeneg, C, Peters, JM, Sorensen, CS, Kramer, E, Lukas, C, Santoni-Rugiu, E	Nature	1999