Dephosphorylation of phospho-Cdh1

Stable Identifier
R-HSA-174124
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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Dephosphorylation of phospho-Cdh1
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Phosphorylation by mitotic kinases is believed to alter the conformation of Cdh1 preventing it from associating with the APC/C. Cdc14 is thought to contribute to the dephosphorylation of Cdh1 in late mitosis. Dephosphorylated Cdh1 then associates with and activates the APC/C.

Literature References
PubMed ID Title Journal Year
11598127 Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a

Bembenek, J, Yu, H

J Biol Chem 2001
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Catalyst Activity

phosphoprotein phosphatase activity of phospho-Cdh1 phosphatase [cytosol]

Physical Entity
phospho-Cdh1 phosphatase [cytosol] (Homo sapiens)
Activity
phosphoprotein phosphatase activity (GO:0004721)
Orthologous Events
Dephosphorylation of phospho-Cdh1 (Caenorhabditis elegans)
Dephosphorylation of phospho-Cdh1 (Canis familiaris)
Dephosphorylation of phospho-Cdh1 (Danio rerio)
Dephosphorylation of phospho-Cdh1 (Drosophila melanogaster)
Dephosphorylation of phospho-Cdh1 (Gallus gallus)
Dephosphorylation of phospho-Cdh1 (Mus musculus)
Dephosphorylation of phospho-Cdh1 (Rattus norvegicus)
Dephosphorylation of phospho-Cdh1 (Saccharomyces cerevisiae)
Dephosphorylation of phospho-Cdh1 (Schizosaccharomyces pombe)
Dephosphorylation of phospho-Cdh1 (Sus scrofa)
Dephosphorylation of phospho-Cdh1 (Xenopus tropicalis)
Authored
Castro, A  (2006-01-26)
Lorca, T  (2006-01-26)
Reviewed
Peters, JM  (2006-03-27)
Created
Matthews, L  (2006-02-17)
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