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ANAPC5 [nucleoplasm]
Stable Identifier
R-HSA-174153
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Apc5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1 polyubiquitinates SKP2 (Homo sapiens)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
RB1 recruits APC/C:Cdh1 complex to SKP2 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
Phosphorylation of the APC/C (Homo sapiens)
Free APC/C phosphorylated by Cyclin B:Cdc2 (Homo sapiens)
anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Free APC/C phosphorylated by Plk1 (Homo sapiens)
anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Multiubiquitination of APC/C-associated Cdh1 (Homo sapiens)
multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
Association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Dissociation of phospho-Cdh1 from the APC/C complex (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Cdh1:APC/C complex binds EHMT1:EHMT2 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Homo sapiens)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Stimulation of IL8 transcription in senescent cells (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of mitotic cell cycle (Homo sapiens)
Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by VENTX (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UJX4 ANAPC5
Gene Names
ANAPC5, APC5
Chain
chain:1-755
Reference Genes
BioGPS Gene:51433 ANAPC5
COSMIC (genes):ANAPC5 ANAPC5
CTD Gene:51433 ANAPC5
dbSNP Gene:51433 ANAPC5
ENSEMBL:ENSG00000089053 ANAPC5
ENSEMBL_homo_sapiens_GENE:ENSG00000089053.13 ANAPC5
HGNC:15713 ANAPC5
KEGG Gene (Homo sapiens):51433 ANAPC5
Monarch:51433 ANAPC5
NCBI Gene:51433 ANAPC5
OMIM:606948 ANAPC5
UCSC:Q9UJX4 ANAPC5
Reference Transcript
RefSeq:NM_016237.4 ANAPC5
RefSeq:NM_001137559.1 ANAPC5
RefSeq:NM_001330489.1 ANAPC5
Other Identifiers
11715599_a_at
16771463
18670994
18670995
18670996
18671001
18671002
18671004
18671005
18671006
18671009
18671011
18671012
18671013
18671015
18671017
18671019
18671020
18671021
18671022
18671025
18671026
18671028
200098_PM_s_at
200098_s_at
208721_PM_s_at
208721_s_at
208722_PM_s_at
208722_s_at
211036_PM_x_at
211036_x_at
3474936
3474937
3474938
3474939
3474940
3474948
3474950
3474951
3474952
3474958
3474960
3474964
3474968
3474974
3474975
3474976
3474977
3474979
3474981
3474983
3474984
3474985
35835_at
51433
7893097
7893346
7893593
7893821
7893856
7893908
7893948
7894295
7894316
7894574
7894665
7894711
7895032
7895042
7895438
7895548
7895658
7896205
7896241
7896269
7896627
7967149
90637_at
A_23_P204448
GE62916
GE79326
GO:0000278
GO:0005515
GO:0005634
GO:0005654
GO:0005680
GO:0005737
GO:0005819
GO:0005829
GO:0005856
GO:0007049
GO:0007059
GO:0007346
GO:0016567
GO:0019903
GO:0022414
GO:0030163
GO:0031145
GO:0036211
GO:0043226
GO:0045842
GO:0051301
GO:0051445
GO:0070979
GO:0140014
HMNXSV003049276
Hs.7101.0.S1_3p_s_at
ILMN_1723177
PH_hs_0000724
TC12002062.hg
g12654502_3p_s_at
Participates
as a component of
anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
ANAPC5 [cytosol]
Inferred To
ANAPC5 [nucleoplasm]
(Bos taurus)
ANAPC5 [nucleoplasm]
(Canis familiaris)
ANAPC5 [nucleoplasm]
(Gallus gallus)
ANAPC5 [nucleoplasm]
(Sus scrofa)
Anapc5 [nucleoplasm]
(Mus musculus)
Anapc5 [nucleoplasm]
(Rattus norvegicus)
ida [nucleoplasm]
(Drosophila melanogaster)
anapc5 [nucleoplasm]
(Dictyostelium discoideum)
anapc5 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001131031.1
,
NP_001317418.1
,
NP_057321.2
OpenTargets
ENSG00000089053
GeneCards
Q9UJX4
HPA
ENSG00000089053-ANAPC5
Ensembl
ENST00000441917
,
ENST00000261819
,
ENSP00000415061
,
ENSP00000261819
,
ENSG00000089053
PRO
Q9UJX4
Pharos - Targets
Q9UJX4
PDB
5G04
,
5KHU
,
6TM5
,
5L9U
,
8PKP
,
6Q6H
,
4UI9
,
5KHR
,
5A31
,
6Q6G
,
5L9T
,
5LCW
,
7QE7
,
6TLJ
,
5G05
,
6TNT
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9JJ66
3
Cdc20 [nucleoplasm]
(R-MMU-6783069)
Cdc20 [nucleoplasm]
(R-MMU-174112)
Cdc20 [cytosol]
(R-MMU-141412)
0.564
2
UniProt:P60484 PTEN
20
K48polyUb-PTEN [cytosol]
(R-HSA-8874327)
PolyUb-PTEN [nucleoplasm]
(R-HSA-6782515)
PTEN H93R [cytosol]
(R-HSA-2318524)
PTEN C124R [cytosol]
(R-HSA-2317439)
PTEN H93Y [cytosol]
(R-HSA-2318520)
PTEN R130G [cytosol]
(R-HSA-2317339)
PTEN H93D [cytosol]
(R-HSA-2318550)
PTEN R130L [cytosol]
(R-HSA-2317430)
PTEN H93A [cytosol]
(R-HSA-2318544)
PTEN G129E [cytosol]
(R-HSA-2318509)
PTEN S170N [cytosol]
(R-HSA-2318408)
PTEN R173P [cytosol]
(R-HSA-2317480)
PTEN R130Q [cytosol]
(R-HSA-2317416)
PTEN H93Q [cytosol]
(R-HSA-2318565)
PTEN G129R [cytosol]
(R-HSA-2318501)
PTEN H123Y [cytosol]
(R-HSA-2318469)
PTEN S170R [cytosol]
(R-HSA-2318437)
PTEN R173C [cytosol]
(R-HSA-2317478)
PTEN R173H [cytosol]
(R-HSA-2317473)
PTEN C124S [cytosol]
(R-HSA-2317379)
0.462
2
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