Reactome | Phosphorylation of Cyclin A:Cdk2 at Tyr 15

Phosphorylation of Cyclin A:Cdk2 at Tyr 15

Stable Identifier

R-HSA-174164

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Phosphorylation of Cyclin A:Cdk2 at Tyr 15

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The CDK activity of the Cyclin A:Cdk2 complex is inhibited by phosphorylation at Tyr-15 by the WEE1 kinase (Gu et al. 1992, Wu et al. 2001). WEE1-mediated phosphorylation of cyclin A-bound CDK2 is positively regulated by CABLES1 (Wu et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11585773	Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers Chung, DC, Zukerberg, LR, Xiao, H, Chuang, Y, Wu, CL, Kirley, SD	Cancer Res	2001
1396589	Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15 Gu, Y, Rosenblatt, J, Morgan, DO	EMBO J	1992