Phosphorylation of Cyclin A:Cdk2 at Tyr 15

Stable Identifier
R-HSA-174164
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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Phosphorylation of Cyclin A:Cdk2 at Tyr 15
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The CDK activity of the Cyclin A:Cdk2 complex is inhibited by phosphorylation at Tyr-15 by the WEE1 kinase (Gu et al. 1992, Wu et al. 2001). WEE1-mediated phosphorylation of cyclin A-bound CDK2 is positively regulated by CABLES1 (Wu et al. 2001).

Literature References
PubMed ID Title Journal Year
11585773 Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers

Chung, DC, Zukerberg, LR, Xiao, H, Chuang, Y, Wu, CL, Kirley, SD

Cancer Res 2001
1396589 Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15

Gu, Y, Rosenblatt, J, Morgan, DO

EMBO J 1992
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of WEE1 [nucleoplasm]

Physical Entity
WEE1 [nucleoplasm] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
This event is regulated
Positively by
Regulator
CABLES1 [nucleoplasm] (Homo sapiens)
Orthologous Events
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Canis familiaris)
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Danio rerio)
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Dictyostelium discoideum)
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Drosophila melanogaster)
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Gallus gallus)
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Mus musculus)
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Rattus norvegicus)
Authored
Pagano, M  (2006-09-19)
Reviewed
Coqueret, O  (2006-10-06)
Created
Matthews, L  (2006-02-17)
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