The CDK activity of the Cyclin A:Cdk2 complex is inhibited by phosphorylation at Tyr-15 by the WEE1 kinase (Gu et al. 1992, Wu et al. 2001). WEE1-mediated phosphorylation of cyclin A-bound CDK2 is positively regulated by CABLES1 (Wu et al. 2001).
Chung, DC, Zukerberg, LR, Xiao, H, Chuang, Y, Wu, CL, Kirley, SD
Gu, Y, Rosenblatt, J, Morgan, DO
protein tyrosine kinase activity of WEE1 [nucleoplasm]
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