Phosphorylation of the Emi1 DSGxxS degron by Plk1

Stable Identifier
R-HSA-174174
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of the Emi1 DSGxxS degron by Plk1
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The phosphorylation of Emi1 by Plk1 is believed to be involved in the degradation of Emi1 during mitosis. Plk1 phosphorylates serine residues in the DSGxxS degron sequence of Emi1 recruiting the SCF(betaTrCP) ubiquitin ligase.

Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T210-PLK1 [nucleoplasm]

Physical Entity
p-T210-PLK1 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Bos taurus)
Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Canis familiaris)
Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Danio rerio)
Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Drosophila melanogaster)
Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Gallus gallus)
Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Mus musculus)
Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Rattus norvegicus)
Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Sus scrofa)
Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Xenopus tropicalis)
Authored
Castro, A  (2006-01-26)
Lorca, T  (2006-01-26)
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-02-17)
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