Reactome | CDC27 [nucleoplasm]

CDC27 [nucleoplasm]

Stable Identifier

R-HSA-174175

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Apc3/Cdc27

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
      - Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        CDC27 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by VENTX (Homo sapiens)
      - Regulation of IL6 transcription (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        CDC27 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30260 CDC27

Gene Names

CDC27, ANAPC3, D0S1430E, D17S978E

Chain

chain:1-824

Reference Genes

BioGPS Gene:996 CDC27

COSMIC (genes):CDC27 CDC27

CTD Gene:996 CDC27

dbSNP Gene:996 CDC27

ENSEMBL:ENSG00000004897 CDC27

ENSEMBL_homo_sapiens_GENE:ENSG00000004897.12 CDC27

HGNC:1728 CDC27

KEGG Gene (Homo sapiens):996 CDC27

Monarch:996 CDC27

NCBI Gene:996 CDC27

OMIM:116946 CDC27

UCSC:P30260 CDC27

Reference Transcript

Other Identifiers

11743400_s_at

11743401_x_at

11743402_at

11743403_a_at

11752920_a_at

16846045

217878_PM_s_at

217878_s_at

217879_PM_at

217879_at

217880_PM_at

217880_at

217881_PM_s_at

217881_s_at

2506480

3760627

3760628

3760629

3760630

3760631

3760632

3760633

3760635

3760636

3760639

3760643

3760646

3760647

3760649

3760650

3760653

3760654

3760656

3760658

3760660

3760661

3760662

3760664

3760677

3760678

3760681

3760684

3760685

3760686

40591_at

63407_at

65511_at

8016324

996

A_23_P66777

GE80996

GE87728

GO:0000278

GO:0005515

GO:0005634

GO:0005654

GO:0005680

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0007059

GO:0007091

GO:0007346

GO:0016567

GO:0019903

GO:0022414

GO:0030163

GO:0031145

GO:0036211

GO:0043226

GO:0051301

GO:0051445

GO:0070979

GO:0072686

HMNXSV003051325

Hs.172405.0.S1_3p_a_at

Hs.172405.0.S3_3p_at

Hs.172405.0.S4_3p_at

ILMN_1746533

PH_hs_0027441

S78234_at

TC17001621.hg

U00001_s_at

g4557015_3p_a_at

Participates

as a component of

Other forms of this molecule

CDC27 [cytosol]

Inferred To

Cdc27 [nucleoplasm] (Drosophila melanogaster)

Cdc27 [nucleoplasm] (Mus musculus)

Cdc27 [nucleoplasm] (Rattus norvegicus)

CDC27 [nucleoplasm] (Bos taurus)

CDC27 [nucleoplasm] (Canis familiaris)

CDC27 [nucleoplasm] (Gallus gallus)

CDC27 [nucleoplasm] (Sus scrofa)

anapc3 [nucleoplasm] (Dictyostelium discoideum)

cdc27 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001247.3, NP_001107563.1

OpenTargets

ENSG00000004897

HPA

ENSG00000004897-CDC27

GeneCards

P30260

Ensembl

ENST00000531206, ENSP00000434614, ENST00000066544, ENSG00000004897, ENSP00000066544

PRO

P30260

Pharos - Targets

P30260

PDB

5KHR, 4RG6, 5L9T, 5A31, 6TM5, 6TNT, 8TAU, 7QE7, 5G05, 4RG9, 6Q6H, 4UI9, 6Q6G, 6TLJ, 5KHU, 5L9U, 8S4G, 5G04, 4RG7, 8TAR, 5LCW, 8PKP, 3T1N

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.942	14
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.914	10
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.905	8
UniProt:Q9UM11 FZR1	4	FZR1 [cytosol] (R-HSA-174249) FZR1 [nucleoplasm] (R-HSA-174099) p-FZR1 [nucleoplasm] (R-HSA-174257) p-FZR1 [cytosol] (R-HSA-174193)	0.879	15
UniProt:Q9UKT4 FBXO5	6	p-S182-FBXO5 [cytosol] (R-HSA-177324) p-S145,S149-FBXO5 [cytosol] (R-HSA-174207) FBXO5 [nucleoplasm] (R-HSA-174060) p-S182-FBXO5 [nucleoplasm] (R-HSA-176447) p-S145,S149-FBXO5 [nucleoplasm] (R-HSA-174220) p-FBXO5 [nucleoplasm] (R-HSA-163049)	0.669	3
UniProt:P51955 NEK2	1	NEK2 [cytosol] (R-HSA-177329)	0.623	3
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.616	7
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.589	2
UniProt:Q9Z1S0	1	BUB1B [cytosol] (R-MMU-141436)	0.564	2
UniProt:Q9JJ66	3	Cdc20 [nucleoplasm] (R-MMU-6783069) Cdc20 [nucleoplasm] (R-MMU-174112) Cdc20 [cytosol] (R-MMU-141412)	0.564	2
UniProt:P31350 RRM2	1	RRM2 [cytosol] (R-HSA-73639)	0.527	3
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.527	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.527	2
UniProt:O43524 FOXO3	11	p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S215 FOXO3 [cytosol] (R-HSA-5687014) FOXO3 [cytosol] (R-HSA-5687032) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) FOXO3 [nucleoplasm] (R-HSA-199305)	0.499	2
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) p-T286-CCND1 [cytosol] (R-HSA-75813)	0.499	3

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