Reactome | PTTG1 [cytosol]

PTTG1 [cytosol]

Stable Identifier

R-HSA-174190

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Securin, Pituitary tumor-transforming gene 1 protein

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O95997 PTTG1

Gene Names

PTTG1, EAP1, PTTG, TUTR1

Chain

initiator methionine:, chain:2-202

Reference Genes

BioGPS Gene:9232 PTTG1

COSMIC (genes):PTTG1 PTTG1

CTD Gene:9232 PTTG1

dbSNP Gene:9232 PTTG1

ENSEMBL:ENSG00000164611 PTTG1

ENSEMBL_homo_sapiens_GENE:ENSG00000164611.13 PTTG1

HGNC:9690 PTTG1

KEGG Gene (Homo sapiens):9232 PTTG1

Monarch:9232 PTTG1

NCBI Gene:9232 PTTG1

OMIM:604147 PTTG1

Reference Transcript

Other Identifiers

11717521_x_at

203554_PM_x_at

203554_x_at

2838202

2838203

2838204

2838205

2838207

2838209

2838211

2838212

2838213

40412_at

8109639

9232

A_14_P126126

A_23_P7636

GE87669

GO:0004869

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0006281

GO:0006974

GO:0007049

GO:0007059

GO:0007283

GO:0017124

GO:0022414

GO:0043226

GO:0045143

GO:0051276

GO:0051301

GO:0098772

GO:0140013

GO:0140677

HMNXSV003055972

ILMN_1753196

ILMN_2042771

TC05000896.hg

g11038651_3p_x_at

Participates

as a component of

as an input of

as a member of

(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Homo sapiens)

Other forms of this molecule

K11polyUb-PTTG1 [cytosol]

Inferred To

XB5905938 [cytosol] (Xenopus tropicalis)

Ghost homologue of PTTG1 [cytosol] (Dictyostelium discoideum)

Ghost homologue of PTTG1 [cytosol] (Drosophila melanogaster)

Pttg1 [cytosol] (Mus musculus)

Pttg1 [cytosol] (Rattus norvegicus)

PTTG1 [cytosol] (Bos taurus)

PTTG1 [cytosol] (Canis familiaris)

PTTG1 [cytosol] (Gallus gallus)

PTTG1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001269312.1, NP_004210.1, NP_001269311.1

OpenTargets

ENSG00000164611

GeneCards

O95997

HPA

ENSG00000164611-PTTG1

Ensembl

ENST00000393964, ENST00000520452, ENSP00000377536, ENSP00000430642, ENST00000352433, ENSP00000344936, ENSG00000164611

PRO

O95997

Pharos - Targets

O95997

PDB

7NJ1, 7NJ0

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14674 ESPL1	4	ESPL1(1-1506) [cytosol] (R-HSA-2467768) ESPL1(1507-1535) [cytosol] (R-HSA-2500272) ESPL1(1536-2120) [cytosol] (R-HSA-2467767) ESPL1 [cytosol] (R-HSA-1638167)	0.748	7
UniProt:Q16698 DECR1	1	DECR1 [mitochondrial matrix] (R-HSA-53523)	0.564	2
UniProt:P60330	4	Espl1 [cytosol] (R-MMU-2467768) Espl1 [cytosol] (R-MMU-2500272) Espl1 [cytosol] (R-MMU-2467767) Espl1 [cytosol] (R-MMU-1638167)	0.564	2
UniProt:P16885 PLCG2	8	p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.488	2