Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PTTG1 [cytosol]
Stable Identifier
R-HSA-174190
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Securin, Pituitary tumor-transforming gene 1 protein
Locations in the PathwayBrowser for interactor UniProt:Q14674 ESPL1
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
Association of Securin with Cdc20:APC/C complex (Homo sapiens)
PTTG1 [cytosol] (Homo sapiens)
PTTG1 (Securin) sequesters ESPL1 (Separase) (Homo sapiens)
PTTG1 [cytosol] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of Securin (Homo sapiens)
Association of Securin with Cdc20:APC/C complex (Homo sapiens)
PTTG1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95997 PTTG1
Gene Names
PTTG1, EAP1, PTTG, TUTR1
Chain
initiator methionine:, chain:2-202
Reference Genes
BioGPS Gene:9232 PTTG1
COSMIC (genes):PTTG1 PTTG1
CTD Gene:9232 PTTG1
dbSNP Gene:9232 PTTG1
ENSEMBL:ENSG00000164611 PTTG1
HGNC:9690 PTTG1
KEGG:hsa:9232 PTTG1
Monarch:9232 PTTG1
NCBI Gene:9232 PTTG1
OMIM:604147 PTTG1
UCSC:O95997 PTTG1
Reference Transcript
RefSeq:NM_001282382.1 PTTG1
RefSeq:NM_004219.3 PTTG1
RefSeq:NM_001282383.1 PTTG1
Other Identifiers
11717521_x_at
16991741
203554_PM_x_at
203554_x_at
2838202
2838203
2838204
2838205
2838206
2838207
2838208
2838209
2838210
2838211
2838212
2838213
40412_at
8109639
9232
A_14_P125413
A_14_P126126
A_23_P7636
GE87669
GO:0004869
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006281
GO:0007059
GO:0007283
GO:0017124
GO:0022414
GO:0043226
GO:0045143
GO:0051276
GO:0051301
GO:0098772
GO:0140677
HMNXSV003055972
ILMN_1753196
ILMN_2042771
TC05000896.hg
g11038651_3p_x_at
Participates
as a component of
PTTG1:ESPL1 [cytosol] (Homo sapiens)
CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
as an input of
PTTG1 (Securin) sequesters ESPL1 (Separase) (Homo sapiens)
Association of Securin with Cdc20:APC/C complex (Homo sapiens)
as a member of
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Homo sapiens)
Other forms of this molecule
K11polyUb-PTTG1 [cytosol]
Inferred To
XB5905938 [cytosol]
(Xenopus tropicalis)
Ghost homologue of PTTG1 [cytosol]
(Dictyostelium discoideum)
Ghost homologue of PTTG1 [cytosol]
(Drosophila melanogaster)
Pttg1 [cytosol]
(Mus musculus)
Pttg1 [cytosol]
(Rattus norvegicus)
PTTG1 [cytosol]
(Bos taurus)
PTTG1 [cytosol]
(Canis familiaris)
PTTG1 [cytosol]
(Gallus gallus)
PTTG1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_004210.1
,
NP_001269312.1
,
NP_001269311.1
ENSEMBL
ENST00000352433
,
ENSP00000344936
,
ENST00000520452
,
ENSP00000377536
,
ENST00000393964
,
ENSP00000430642
OpenTargets
ENSG00000164611
HPA
ENSG00000164611-PTTG1
PRO
O95997
Pharos - Targets
O95997
PDB
7NJ1
,
7NJ0
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14674 ESPL1
4
ESPL1(1-1506) [cytosol]
(R-HSA-2467768)
ESPL1(1507-1535) [cytosol]
(R-HSA-2500272)
ESPL1(1536-2120) [cytosol]
(R-HSA-2467767)
ESPL1 [cytosol]
(R-HSA-1638167)
0.803
8
UniProt:Q16698 DECR1
1
DECR1 [mitochondrial matrix]
(R-HSA-53523)
0.669
3
UniProt:P60330
4
Espl1 [cytosol]
(R-MMU-2467768)
Espl1 [cytosol]
(R-MMU-2500272)
Espl1 [cytosol]
(R-MMU-2467767)
Espl1 [cytosol]
(R-MMU-1638167)
0.564
2
UniProt:P16885 PLCG2
8
p-PLCG2 [plasma membrane]
(R-HSA-114602)
PLCG2 [plasma membrane]
(R-HSA-114601)
p-Y753,Y759,Y1217-PLCG2 [plasma membrane]
(R-HSA-984816)
PLCG2 [cytosol]
(R-HSA-984806)
p-4Y-PLCG2 [plasma membrane]
(R-HSA-2685601)
p-Y753,Y759-PLCG2 [plasma membrane]
(R-HSA-5607640)
p-Y753,Y759-PLCG2 [cytosol]
(R-HSA-5607631)
p-Y-PLCG2 [cytosol]
(R-HSA-9029105)
0.488
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text