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SCF-mediated degradation of Emi1
Stable Identifier
R-HSA-174203
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
SCF-beta-TrCP mediated degradation of Emi1 (Homo sapiens)
SCF-mediated degradation of Emi1 (Homo sapiens)
General
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Multiubiquitinated Emi1 is degraded by the 26S proteasome.
Literature References
PubMed ID
Title
Journal
Year
15469984
Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1
Hansen, DV
,
Loktev, AV
,
Ban, KH
Mol Biol Cell
2004
Participants
Input
SCF-associated multiubiquitinated Emi1complexes [cytosol]
(Homo sapiens)
Output
BTRC:CUL1:SKP1 [cytosol]
(Homo sapiens)
Cdc20/Cdh1 [cytosol]
(Homo sapiens)
x 4
Ub [cytosol]
(Homo sapiens)
Participates
as an event of
SCF-beta-TrCP mediated degradation of Emi1 (Homo sapiens)
Catalyst Activity
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
26S proteasome [cytosol]
(Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
SCF-mediated degradation of Emi1 (Rattus norvegicus)
Authored
Castro, A (2006-01-26)
Lorca, T (2006-01-26)
Reviewed
Peters, JM (2006-03-28)
Created
Matthews, L (2006-02-17)
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