Reactome | Phosphorylated Emi1 binds the beta-TrCP in the SCF complex

Phosphorylated Emi1 binds the beta-TrCP in the SCF complex

Stable Identifier

R-HSA-174209

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
        
        SCF-beta-TrCP mediated degradation of Emi1 (Homo sapiens)
        
        Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Homo sapiens)

General

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Phosphorylated Emi1 binds the beta-TrCP in the SCF complex

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Cdk mediated phosphorylation of Emi1 is believed to promotes its phospho- Ser145-Ser149 dependent association with beta-TrCP.

Literature References

PubMed ID	Title	Journal	Year
12791267	Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase Reimann, JD, Loktev, A, Hsu, JY, Jackson, PK, Margottin-Goguet, F, Hsieh, HM	Dev Cell	2003
10023660	The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin Chiaur, DS, Latres, E, Pagano, M	Oncogene	1999