Reactome | Degradation multiubiquitinated Cyclin A

Degradation multiubiquitinated Cyclin A

Stable Identifier

R-HSA-174255

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Homo sapiens)
        
        Degradation multiubiquitinated Cyclin A (Homo sapiens)

General

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Following multiubiquitination, Cyclin A is targeted for destruction by the 26S proteasome.

Literature References

PubMed ID	Title	Journal	Year
11285280	Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint Peters, JM, Gannon, J, Geley, S, Kramer, E, Gieffers, C, Hunt, T	J Cell Biol	2001