Reactome | PSMD2 [nucleoplasm]

PSMD2 [nucleoplasm]

Stable Identifier

R-HSA-174311

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit S2, 26S proteasome subunit p97, Tumor necrosis factor type 1 receptor associated protein 2, 55.11 protein

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMD2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13200 PSMD2

Gene Names

PSMD2, TRAP2

Chain

chain:1-908

Reference Genes

BioGPS Gene:5708 PSMD2

COSMIC (genes):PSMD2 PSMD2

CTD Gene:5708 PSMD2

dbSNP Gene:5708 PSMD2

ENSEMBL:ENSG00000175166 PSMD2

ENSEMBL:ENSG00000175166.17 PSMD2

HGNC:9559 PSMD2

KEGG Gene (Homo sapiens):5708 PSMD2

Monarch:5708 PSMD2

NCBI Gene:5708 PSMD2

OMIM:606223 PSMD2

UCSC:Q13200 PSMD2

Reference Transcript

Other Identifiers

1166_at

11715565_at

11758266_s_at

11758702_s_at

16948871

200830_PM_at

200830_at

2463105

2463107

2463110

2463111

2463113

2463117

2463118

2463119

2463120

2463127

2463128

2655654

2655658

2655659

2655660

2655662

2655663

2655665

2655666

2655667

2655668

2655670

2655672

2655673

2655675

2655677

2655678

2655679

2655680

2655682

2655683

2655684

2655686

2655687

5708

8084423

A_24_P42681

A_33_P3373469

D78151_at

GE57295

GE58933

GO:0000502

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005829

GO:0005838

GO:0008540

GO:0016020

GO:0022624

GO:0030163

GO:0030234

GO:0031410

GO:0034515

GO:0034774

GO:0042176

GO:0043161

GO:0043226

GO:0070062

GO:0098772

GO:1904813

HMNXSV003047036

ILMN_1712432

PH_hs_0030008

TC03000999.hg

g4506226_3p_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMD2 [secretory granule lumen]

PSMD2 [extracellular region]

PSMD2 [ficolin-1-rich granule lumen]

PSMD2 [cytosol]

Inferred To

Ghost homologue of PSMD2 [nucleoplasm] (Danio rerio)

Ghost homologue of PSMD2 [nucleoplasm] (Sus scrofa)

PSMD2 [nucleoplasm] (Bos taurus)

PSMD2 [nucleoplasm] (Canis familiaris)

PSMD2 [nucleoplasm] (Gallus gallus)

Rpn1 [nucleoplasm] (Drosophila melanogaster)

psmd2 [nucleoplasm] (Xenopus tropicalis)

psmD2 [nucleoplasm] (Dictyostelium discoideum)

Psmd2 [nucleoplasm] (Mus musculus)

Psmd2 [nucleoplasm] (Rattus norvegicus)

rpn-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002799.3, NP_001265637.1, NP_001265638.1

OpenTargets

ENSG00000175166

GeneCards

Q13200

HPA

ENSG00000175166-PSMD2

Ensembl

ENSP00000402618, ENST00000439383, ENSP00000310129, ENST00000435761, ENST00000310118, ENSG00000175166, ENSP00000416028

PRO

Q13200

Pharos - Targets

Q13200

PDB

5VFP, 5VHS, 7W3J, 5T0I, 5VFU, 7QXU, 6WJD, 7QXW, 5GJR, 5T0H, 7W3K, 5GJQ, 7W3H, 5VHQ, 7QYB, 5VFQ, 6MSG, 5VHR, 7W3I, 6MSH, 5VHO, 6MSB, 7W37, 5L4K, 6MSD, 5VHP, 7W38, 8CVT, 5VHM, 7QYA, 5T0G, 5T0C, 5LN3, 5VHN, 5VHI, 7W3A, 5VHH, 6MSJ, 7QXP, 5VFR, 5VHJ, 5T0J, 7UJD, 7W39, 7W3F, 7W3G, 7QXN, 6MSK, 5VFT, 7W3M, 5VHF, 7QY7, 6WJN, 7UIH, 7W3B, 7QXX, 7W3C, 5VFS

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.758	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	17
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.623	4
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.621	3
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.61	4
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.602	3
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.589	2
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
UniProt:P17612 PRKACA	3	PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.556	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	3

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