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PSMD2 [nucleoplasm]
Stable Identifier
R-HSA-174311
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit S2, 26S proteasome subunit p97, Tumor necrosis factor type 1 receptor associated protein 2, 55.11 protein
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD2 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD2 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD2 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD2 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD2 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD2 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD2 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD2 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13200 PSMD2
Gene Names
PSMD2, TRAP2
Chain
chain:1-908
Reference Genes
BioGPS Gene:5708 PSMD2
COSMIC (genes):PSMD2 PSMD2
CTD Gene:5708 PSMD2
dbSNP Gene:5708 PSMD2
ENSEMBL:ENSG00000175166 PSMD2
HGNC:9559 PSMD2
KEGG Gene (Homo sapiens):5708 PSMD2
Monarch:5708 PSMD2
NCBI Gene:5708 PSMD2
OMIM:606223 PSMD2
UCSC:Q13200 PSMD2
Reference Transcript
RefSeq:NM_001278708.1 PSMD2
RefSeq:NM_001278709.1 PSMD2
RefSeq:NM_002808.4 PSMD2
Other Identifiers
0000070433
1166_at
11715565_at
11758266_s_at
11758702_s_at
16948871
200830_at
2463105
2463107
2463110
2463111
2463113
2463117
2463118
2463119
2463120
2463127
2463128
2655654
2655658
2655659
2655660
2655662
2655663
2655665
2655666
2655667
2655668
2655670
2655672
2655673
2655675
2655677
2655678
2655679
2655680
2655682
2655683
2655684
2655686
2655687
5708
8084423
A_24_P42681
A_33_P3373469
D78151_at
GE57295
GE58933
GO:0000165
GO:0000209
GO:0000278
GO:0000502
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0004175
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005838
GO:0006464
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0008233
GO:0008540
GO:0009056
GO:0009058
GO:0010972
GO:0016020
GO:0016192
GO:0016579
GO:0022607
GO:0022624
GO:0030154
GO:0030234
GO:0031145
GO:0031146
GO:0031410
GO:0032991
GO:0033209
GO:0034515
GO:0034641
GO:0034655
GO:0034774
GO:0036388
GO:0038061
GO:0038095
GO:0042176
GO:0043161
GO:0043226
GO:0043312
GO:0043488
GO:0043687
GO:0044281
GO:0048856
GO:0050790
GO:0050852
GO:0055085
GO:0060071
GO:0061418
GO:0065003
GO:0070062
GO:0070498
GO:0090090
GO:0090263
GO:1901990
GO:1902036
GO:1904813
HMNXSV003047036
ILMN_1712432
PH_hs_0030008
TC03000999.hg
g4506226_3p_at
Participates
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMD2 [secretory granule lumen]
PSMD2 [extracellular region]
PSMD2 [ficolin-1-rich granule lumen]
PSMD2 [cytosol]
Inferred To
Ghost homologue of PSMD2 [nucleoplasm]
(Danio rerio)
Ghost homologue of PSMD2 [nucleoplasm]
(Sus scrofa)
PSMD2 [nucleoplasm]
(Canis familiaris)
Rpn1 [nucleoplasm]
(Drosophila melanogaster)
psmD2 [nucleoplasm]
(Dictyostelium discoideum)
Psmd2 [nucleoplasm]
(Mus musculus)
Psmd2 [nucleoplasm]
(Rattus norvegicus)
rpn1 [nucleoplasm]
(Schizosaccharomyces pombe)
rpn-1 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_002799.3
,
NP_001265638.1
,
NP_001265637.1
OpenTargets
ENSG00000175166
HPA
ENSG00000175166-PSMD2
GeneCards
Q13200
Ensembl
ENSP00000416028
,
ENSG00000175166
,
ENST00000310118
,
ENSP00000402618
,
ENST00000435761
,
ENSP00000310129
,
ENST00000439383
PRO
Q13200
Pharos - Targets
Q13200
GlyGen
Q13200
PDB
5VFQ
,
5VHF
,
5T0H
,
5VFR
,
5VFP
,
5VHH
,
5LN3
,
5T0G
,
5VFS
,
6MSB
,
5VHI
,
5VFT
,
5VHJ
,
5T0C
,
5VFU
,
6WJD
,
6MSD
,
6MSG
,
5VHM
,
5L4K
,
5VHN
,
6MSH
,
5VHO
,
6WJN
,
6MSJ
,
5VHP
,
6MSK
,
5VHQ
,
5VHR
,
5VHS
,
5GJR
,
5GJQ
,
5T0J
,
5T0I
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.758
5
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.643
11
UniProt:P50454 SERPINH1
1
SERPINH1 [endoplasmic reticulum lumen]
(R-HSA-2127480)
0.61
4
UniProt:Q16186 ADRM1
1
ADRM1 [cytosol]
(R-HSA-5665939)
0.602
3
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
0.589
2
UniProt:P27797 CALR
6
CALR [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
0.556
3
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128fs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128fs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.556
3
UniProt:P17612 PRKACA
3
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [cytosol]
(R-HSA-57844)
0.556
3
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.527
3
UniProt:P10636-8 MAPT
2
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.491
3
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