Reactome | PSMC5 [nucleoplasm]

PSMC5 [nucleoplasm]

Stable Identifier

R-HSA-174312

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Probable 26S protease regulatory subunit 8

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
        
        Degradation of multiubiquitinated Cdh1 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)

DNA Replication (Homo sapiens)

- DNA Replication Pre-Initiation (Homo sapiens)
  - Assembly of the pre-replicative complex (Homo sapiens)
    - Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Gastrulation (Homo sapiens)
  - Formation of paraxial mesoderm (Homo sapiens)
    - Somitogenesis (Homo sapiens)
      - RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)
        
        TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - Regulation of RUNX2 expression and activity (Homo sapiens)
        
        26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX3 (Homo sapiens)
      - Regulation of RUNX3 expression and activity (Homo sapiens)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Homo sapiens)
        
        USP37:RUVLB1:PSMC5:CCNA1,CCNA2 [nucleoplasm] (Homo sapiens)
        
        USP37:RUVLB1:PSMC5 [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)
        
        USP37:RUVLB1:PSMC5:PolyUb-CCNA1,PolyUb-CCNA2 [nucleoplasm] (Homo sapiens)
        
        USP37:RUVLB1:PSMC5 [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Hedgehog (Homo sapiens)
  - Hedgehog 'on' state (Homo sapiens)
    - GLI2,3 are degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)
- Signaling by NOTCH (Homo sapiens)
  - Signaling by NOTCH4 (Homo sapiens)
    - Negative regulation of NOTCH4 signaling (Homo sapiens)
      - Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62195 PSMC5

Gene Names

PSMC5, SUG1

Chain

initiator methionine:, chain:2-406

Reference Genes

BioGPS Gene:5705 PSMC5

COSMIC (genes):PSMC5 PSMC5

CTD Gene:5705 PSMC5

dbSNP Gene:5705 PSMC5

ENSEMBL:ENSG00000087191 PSMC5

HGNC:9552 PSMC5

KEGG:hsa:5705 PSMC5

Monarch:5705 PSMC5

NCBI Gene:5705 PSMC5

OMIM:601681 PSMC5

UCSC:P62195 PSMC5

Reference Transcript

Other Identifiers

11756554_x_at

16837029

209503_PM_s_at

209503_s_at

3730942

3730943

3730944

3730945

3730946

3730947

3730948

3730949

3730950

3730951

3730952

3730953

3730954

3730955

3730956

3730957

3730958

3730959

3730960

3730961

3730962

3730963

3730964

3730965

3730966

3730967

3730968

3730969

3730970

3730971

3730972

3730973

37766_s_at

5705

8009227

A_14_P106486

A_14_P125043

A_23_P164035

GE54277

GO:0000502

GO:0003824

GO:0005102

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005838

GO:0006355

GO:0006357

GO:0008134

GO:0008540

GO:0016020

GO:0016787

GO:0016887

GO:0022624

GO:0030163

GO:0031410

GO:0031531

GO:0036402

GO:0043069

GO:0043161

GO:0043226

GO:0045892

GO:0045893

GO:0070062

GO:0072562

GO:0140296

GO:0140297

GO:0140657

GO:1901800

HMNXSV003036198

ILMN_1780189

L38810_at

PH_hs_0004597

TC17000772.hg

g2661070_3p_a_at

Participates

as a component of

Other forms of this molecule

PSMC5 [cytosol]

Inferred To

Ghost homologue of PSMC5 [nucleoplasm] (Dictyostelium discoideum)

PSMC5 [nucleoplasm] (Bos taurus)

PSMC5 [nucleoplasm] (Caenorhabditis elegans)

PSMC5 [nucleoplasm] (Canis familiaris)

PSMC5 [nucleoplasm] (Drosophila melanogaster)

PSMC5 [nucleoplasm] (Gallus gallus)

PSMC5 [nucleoplasm] (Mus musculus)

PSMC5 [nucleoplasm] (Rattus norvegicus)

PSMC5 [nucleoplasm] (Schizosaccharomyces pombe)

PSMC5 [nucleoplasm] (Sus scrofa)

psmc5 [nucleoplasm] (Danio rerio)

psmc5 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001186092.1, NP_002796.4

OpenTargets

ENSG00000087191

ENSEMBL

ENSP00000364970, ENSP00000462495, ENST00000580864, ENSP00000310572, ENST00000375812, ENST00000581882, ENSP00000463938, ENST00000310144

HPA

ENSG00000087191-PSMC5

PRO

P62195

Pharos - Targets

P62195

GlyGen

P62195

PDB

3KW6, 5VHH, 5VHO, 7QYB, 5VHI, 5L4G, 5GJQ, 8CVT, 5T0I, 7W3F, 5VHS, 7QXX, 7QY7, 5VHN, 7W3C, 5GJR, 6MSH, 5T0H, 5VGZ, 6WJN, 6MSG, 7W37, 7W38, 5VHF, 6MSK, 7W3H, 5VFR, 7W3J, 5VFU, 5VFT, 6WJD, 2KRK, 5VHP, 7QYA, 5VHQ, 5T0C, 5VHR, 5VHJ, 5T0J, 7W3K, 7W3M, 7QXN, 7QXP, 6MSD, 5M32, 5VHM, 7W39, 5T0G, 5LN3, 7QXW, 7W3G, 7QXU, 7W3B, 6MSB, 7W3A, 7W3I, 5VFP, 5VFQ, 6MSJ, 5VFS

Interactors (71)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.939	17
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.938	20
UniProt:Q13371 PDCL	2	p-S18,S19,S20,S25-PDCL [cytosol] (R-HSA-6814228) PDCL [cytosol] (R-HSA-6813727)	0.919	16
UniProt:P35998 PSMC2	5	PSMC2 [cytosol] (R-HSA-68771) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421)	0.864	14
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.84	14
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435)	0.823	14
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.802	11
UniProt:Q96BD8 SKA1	1	SKA1 [cytosol] (R-HSA-376228)	0.8	8
UniProt:Q9BRP4 PAAF1	1	PAAF1 [cytosol] (R-HSA-9907973)	0.793	6
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.788	8
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406)	0.788	6
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.758	4
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.758	12
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429)	0.758	10
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.744	5
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440)	0.744	6
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.742	5
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436)	0.725	5
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408)	0.725	7
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.725	6
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413)	0.669	5
UniProt:O76015 KRT38	1	KRT38 [cytosol] (R-HSA-6809615)	0.666	6
UniProt:Q53GL0 PKHO1			0.664	10
UniProt:P62508-3 ESRRG			0.659	5
UniProt:Q96EK4 THA11			0.659	3
UniProt:O00487 PSMD14	5	PSMD14 [cytosol] (R-HSA-68722) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419)	0.643	4
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.643	4
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.643	4
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416)	0.643	4
UniProt:Q15018 FAM175B	1	FAM175B [cytosol] (R-HSA-5691428)	0.643	4
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.643	4
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.643	4
UniProt:P19447 ERCC3	1	ERCC3 [nucleoplasm] (R-HSA-67439)	0.576	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	9
UniProt:P51449 RORC	1	RORC [nucleoplasm] (R-HSA-446177)	0.556	3
UniProt:Q9BYV9 BACH2			0.556	3
UniProt:P06753 TPM3	3	TPM3(2-258)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710848) TPM3(2-258)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710837) TPM3 [cytosol] (R-HSA-390543)	0.556	3
UniProt:Q8IYR0 CF206			0.556	3
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.556	3
UniProt:Q6FG41 Q6FG41			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q13515 BFSP2			0.556	3
UniProt:P10826-2 RARB			0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:P48788 TNNI2	1	TNNI2 [cytosol] (R-HSA-390538)	0.556	3
UniProt:Q92753-1 Q927531			0.556	3
UniProt:P09493-10 TPM1			0.556	3
IntAct:EBI-16435328 CCSB ORF ID			0.556	3
UniProt:P13805 TNNT1	1	TNNT1 [cytosol] (R-HSA-390544)	0.553	2
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.553	2
UniProt:P35398 RORA	3	polySUMO2-K240-RORA [nucleoplasm] (R-HSA-4719425) monoSUMO1-K240-RORA [nucleoplasm] (R-HSA-4719422) RORA [nucleoplasm] (R-HSA-400325)	0.553	2
UniProt:Q9NR09 BIRC6	2	BIRC6(1-958)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713451) BIRC6(1-958)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713450)	0.527	2
UniProt:P46063 RECQ1			0.527	2
UniProt:Q53HC0 CCD92			0.527	2
UniProt:Q9H9E3 COG4	2	COG4 [trans-Golgi network membrane] (R-HSA-6813868) COG4 [Golgi membrane] (R-HSA-6808722)	0.527	2
UniProt:Q8IWB1 IPRI			0.527	2
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.527	2
UniProt:Q8IWJ2 GCC2	3	GCC2 [cytosol] (R-HSA-6813880) GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9713455) GCC2(1-1204)-ALK(1059-1620) fusion [cytosol] (R-HSA-9713458)	0.527	3
UniProt:P68871 HBB	8	HBB [lysosomal lumen] (R-HSA-9625193) HBB [cytosol] (R-HSA-1008196) HBB [late endosome lumen] (R-HSA-9631108) HBB [tertiary granule lumen] (R-HSA-6800191) HBB [extracellular region] (R-HSA-2168872) HBB [ficolin-1-rich granule lumen] (R-HSA-6801015) HBB [endocytic vesicle lumen] (R-HSA-2230936) CO-H+-HBB [cytosol] (R-HSA-1237013)	0.527	2
UniProt:Q5VSL9 STRP1			0.527	2
UniProt:Q8N1B4 VPS52	1	VPS52 [trans-Golgi network membrane] (R-HSA-6811029)	0.527	2
UniProt:O14715 RGPD8			0.527	3
UniProt:Q99666 RGPD5			0.527	3
UniProt:O43805 SSNA1	1	SSNA1 [cytosol] (R-HSA-380255)	0.527	3
UniProt:Q6UWZ7 FAM175A	1	p-S406-FAM175A [nucleoplasm] (R-HSA-5682575)	0.527	2
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.527	2
UniProt:O00233 PSMD9	1	PSMD9 [cytosol] (R-HSA-68810)	0.527	2
UniProt:P03255-1			0.524	2
UniProt:O15066 KIF3B	3	KIF3B [ciliary tip] (R-HSA-5625378) KIF3B [cilium] (R-HSA-5624878) KIF3B [cytosol] (R-HSA-984662)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	11

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