Reactome | PSMC3 [nucleoplasm]

PSMC3 [nucleoplasm]

Stable Identifier

R-HSA-174313

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S protease regulatory subunit 6A, TAT-binding protein 1, TBP-1, Proteasome subunit P50

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMC3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P17980 PSMC3

Gene Names

PSMC3, TBP1

Chain

chain:1-439

Reference Genes

BioGPS Gene:5702 PSMC3

COSMIC (genes):PSMC3 PSMC3

CTD Gene:5702 PSMC3

dbSNP Gene:5702 PSMC3

ENSEMBL:ENSG00000165916 PSMC3

ENSEMBL:ENSG00000165916.9 PSMC3

HGNC:9549 PSMC3

KEGG Gene (Homo sapiens):5702 PSMC3

Monarch:5702 PSMC3

NCBI Gene:5702 PSMC3

OMIM:186852 PSMC3

UCSC:P17980 PSMC3

Reference Transcript

RefSeq:NM_002804.4 PSMC3

Other Identifiers

11715815_a_at

16738023

201267_PM_s_at

201267_s_at

3164161

3164167

3164172

3164173

3372212

3372213

3372215

3372216

3372217

3372218

3372219

3372220

3372221

3372222

3372223

3372224

3372225

3372226

3372227

3372229

3372230

5702

592_at

7947867

A_23_P104607

GE61288

GO:0000166

GO:0000502

GO:0000932

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0008540

GO:0016020

GO:0016787

GO:0016887

GO:0022624

GO:0030163

GO:0031410

GO:0034774

GO:0036402

GO:0042802

GO:0043161

GO:0043226

GO:0043921

GO:0045944

GO:0140657

GO:1901800

GO:1904813

HMNXSV003034992

Hs.250758.0.S1_3p_s_at

ILMN_1809010

M34079_at

PH_hs_0028031

TC11001738.hg

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMC3 [secretory granule lumen]

PSMC3 [extracellular region]

PSMC3 [ficolin-1-rich granule lumen]

PSMC3 [cytosol]

Inferred To

wu:fb39a02 [nucleoplasm] (Danio rerio)

Rpt5 [nucleoplasm] (Drosophila melanogaster)

PSMC3 [nucleoplasm] (Bos taurus)

PSMC3 [nucleoplasm] (Caenorhabditis elegans)

PSMC3 [nucleoplasm] (Canis familiaris)

PSMC3 [nucleoplasm] (Dictyostelium discoideum)

PSMC3 [nucleoplasm] (Gallus gallus)

PSMC3 [nucleoplasm] (Mus musculus)

PSMC3 [nucleoplasm] (Rattus norvegicus)

PSMC3 [nucleoplasm] (Sus scrofa)

psmc3 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_002795.2

OpenTargets

ENSG00000165916

HPA

ENSG00000165916-PSMC3

GeneCards

P17980

Ensembl

ENSP00000481029, ENST00000298852, ENSP00000298852, ENSG00000165916, ENST00000619920

PRO

P17980

Pharos - Targets

P17980

PDB

7QY7, 7QXX, 5L4G, 5VFP, 5VFQ, 7QXU, 5LN3, 5VFS, 6MSB, 5T0C, 7QXW, 5VFR, 6MSE, 5VFU, 7W3A, 5T0G, 6MSD, 7W3J, 7W3K, 5M32, 5VFT, 6MSH, 5VHI, 6MSG, 5T0I, 7W3H, 7W39, 7W3I, 5VHR, 5T0H, 5VHQ, 6MSJ, 6WJN, 7W3G, 7W3F, 7W37, 8CVT, 7W38, 5T0J, 5VHJ, 5VHS, 7W3C, 7W3B, 6WJD, 5VGZ, 7W3M, 5VHN, 5VHM, 6MSK, 5GJR, 5VHF, 5GJQ, 5VHP, 5VHO, 7QYA, 7QYB, 7QXN, 5VHH, 7QXP

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.919	16
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.669	4
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	6
UniProt:P00441 SOD1	5	SOD1 [extracellular region] (R-HSA-350705) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	6
UniProt:O14561 NDUFAB1	3	Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8934586) PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8933545) NDUFAB1 [mitochondrial inner membrane] (R-HSA-163925)	0.556	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.556	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.547	2
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	7

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