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PSMA6 [nucleoplasm]
Stable Identifier
R-HSA-174314
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit alpha type 6 , Proteasome iota chain, Macropain iota chain, Multicatalytic endopeptidase complex iota chain, 27 kDa prosomal protein, PROS-27, p27K
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA6 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA6 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA6 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA6 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA6 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA6 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA6 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA6 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA6 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA6 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60900 PSMA6
Gene Names
PSMA6, PROS27
Chain
chain:1-246
Reference Genes
BioGPS Gene:5687 PSMA6
COSMIC (genes):PSMA6 PSMA6
CTD Gene:5687 PSMA6
dbSNP Gene:5687 PSMA6
ENSEMBL:ENSG00000100902.11 PSMA6
HGNC:9535 PSMA6
KEGG Gene (Homo sapiens):5687 PSMA6
Monarch:5687 PSMA6
NCBI Gene:5687 PSMA6
OMIM:602855 PSMA6
UCSC:P60900 PSMA6
Reference Transcript
RefSeq:XM_017021468.1 PSMA6
RefSeq:NM_001282232.1 PSMA6
RefSeq:NM_001282233.1 PSMA6
RefSeq:NM_001282234.1 PSMA6
RefSeq:NM_002791.2 PSMA6
Other Identifiers
0003990368
11757295_x_at
208805_3p_at
208805_PM_at
208805_at
3532457
3532459
3532460
3532461
3532462
3532465
3532468
3532469
3532472
3532473
3532475
3532479
3532480
3532481
3532482
36122_at
4030209
4030210
4030212
4030213
5687
7973936
A_23_P25735
GE59844
GO:0000502
GO:0000932
GO:0003723
GO:0004175
GO:0005515
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0005844
GO:0006351
GO:0006355
GO:0006511
GO:0006954
GO:0010498
GO:0016363
GO:0016787
GO:0019773
GO:0030016
GO:0030017
GO:0030163
GO:0032991
GO:0035639
GO:0043161
GO:0043226
GO:0050727
GO:0051059
GO:0051092
GO:0051603
GO:0070062
GO:0140096
HMNXSV003043053
ILMN_1704094
ILMN_2151818
TC14002294.hg
X59417_at
g12804240_3p_at
g12804240_3p_s_at
Participates
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMA6 [cytosol]
Inferred To
pas-1 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of PSMA6 [nucleoplasm]
(Canis familiaris)
Ghost homologue of PSMA6 [nucleoplasm]
(Sus scrofa)
PSMA6 [nucleoplasm]
(Bos taurus)
PSMA6 [nucleoplasm]
(Canis familiaris)
PSMA6 [nucleoplasm]
(Danio rerio)
PSMA6 [nucleoplasm]
(Gallus gallus)
psma6 [nucleoplasm]
(Xenopus tropicalis)
Prosalpha1 [nucleoplasm]
(Drosophila melanogaster)
psmA6 [nucleoplasm]
(Dictyostelium discoideum)
Proteasome subunit alpha type-6 [nucleoplasm]
(Mus musculus)
Psma6 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_002782.1
,
NP_001269161.1
,
NP_001269163.1
,
XP_016876957.1
,
NP_001269162.1
OpenTargets
ENSG00000100902
HPA
ENSG00000100902-PSMA6
GeneCards
P60900
Ensembl
ENST00000622405
,
ENST00000540871
,
ENSP00000261479
,
ENST00000261479
,
ENSG00000100902
,
ENSP00000479620
,
ENSP00000444844
,
ENST00000555764
,
ENSP00000452566
PRO
P60900
Pharos - Targets
P60900
PDB
6MSD
,
5LF1
,
5VFS
,
5VFO
,
5LF4
,
4R67
,
5T0G
,
6XMJ
,
6WJD
,
6R70
,
5VFT
,
7AWE
,
5LF6
,
5T0H
,
5VFQ
,
7V5G
,
6KWY
,
5LF7
,
6REY
,
5T0C
,
5LEY
,
5T0I
,
5GJQ
,
5LE5
,
4R3O
,
5M32
,
5LF0
,
7NHT
,
5T0J
,
6MSK
,
6RGQ
,
5LF3
,
5VFP
,
5A0Q
,
5GJR
,
7PG9
,
6MSH
,
6E5B
,
7LXV
,
6MSG
,
5VFU
,
6AVO
,
7V5M
,
5L4G
,
6MSB
,
5LEZ
,
5VFR
,
7B12
,
5LEX
,
6WJN
,
5LN3
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.669
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
4
UniProt:Q9BY67 CADM1
1
CADM1 [plasma membrane]
(R-HSA-420589)
0.556
3
UniProt:P62875 POLR2L
2
POLR2L [nucleoplasm]
(R-HSA-83715)
POLR2L [cytosol]
(R-HSA-1964467)
0.556
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.495
2
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