Reactome | PSMC6 [nucleoplasm]

PSMC6 [nucleoplasm]

Stable Identifier

R-HSA-174319

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S protease regulatory subunit S10B, Proteasome subunit p42, p44, Conserved ATPase domain protein 44, CADp44

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMC6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62333 PSMC6

Gene Names

PSMC6, SUG2

Chain

chain:1-389

Reference Genes

BioGPS Gene:5706 PSMC6

COSMIC (genes):PSMC6 PSMC6

CTD Gene:5706 PSMC6

dbSNP Gene:5706 PSMC6

ENSEMBL:ENSG00000100519 PSMC6

ENSEMBL:ENSG00000100519.12 PSMC6

HGNC:9553 PSMC6

KEGG Gene (Homo sapiens):5706 PSMC6

Monarch:5706 PSMC6

NCBI Gene:5706 PSMC6

OMIM:602708 PSMC6

UCSC:P62333 PSMC6

Reference Transcript

RefSeq:NM_002806.3 PSMC6

Other Identifiers

11720983_s_at

16784228

201699_PM_at

201699_at

3136120

3136122

3136123

3136124

3136125

3136126

3136127

3136128

3535886

3535889

3535890

3535892

3535896

3535897

3535898

3535899

3535904

3535906

3535907

3535910

3535911

3535914

3535916

3535917

3535918

3535919

3535920

3535921

5706

7974380

8150870

949_s_at

A_23_P128930

A_24_P381625

D78275_at

GE57296

GO:0000166

GO:0000502

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0008540

GO:0016020

GO:0016234

GO:0016787

GO:0016887

GO:0022624

GO:0030163

GO:0030433

GO:0030674

GO:0031597

GO:0036402

GO:0042802

GO:0043161

GO:0043226

GO:0045899

GO:0060090

GO:0065003

GO:0070062

GO:0090261

GO:0140657

GO:1901800

HMNXSV003008240

ILMN_1655316

ILMN_2096759

PH_hs_0029255

TC14000309.hg

g4506214_3p_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMC6 [cytosol]

Inferred To

Ghost homologue of PSMC6 [nucleoplasm] (Xenopus tropicalis)

Psmc6 [nucleoplasm] (Rattus norvegicus)

fb20g04 [nucleoplasm] (Danio rerio)

Homologues of PSMC6 [nucleoplasm] (Canis familiaris)

Rpt4 [nucleoplasm] (Drosophila melanogaster)

PSMC6 [nucleoplasm] (Bos taurus)

PSMC6 [nucleoplasm] (Caenorhabditis elegans)

PSMC6 [nucleoplasm] (Canis familiaris)

PSMC6 [nucleoplasm] (Dictyostelium discoideum)

PSMC6 [nucleoplasm] (Gallus gallus)

PSMC6 [nucleoplasm] (Mus musculus)

PSMC6 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_002797.3

OpenTargets

ENSG00000100519

GeneCards

P62333

HPA

ENSG00000100519-PSMC6

Ensembl

ENSG00000100519, ENSP00000401802, ENST00000445930

PRO

P62333

Pharos - Targets

P62333

PDB

6MSH, 5VHR, 5VFU, 5GJQ, 5VHI, 5GJR, 8CVT, 5T0H, 5VHQ, 5VHH, 6MSG, 5T0G, 6MSE, 5VFS, 5VHP, 5M32, 5VHN, 5LN3, 5VHF, 5VFT, 5T0C, 6MSD, 5VHO, 5L4G, 6MSB, 5VFQ, 5VGZ, 5VFR, 5VHM, 6WJN, 6MSK, 5VHJ, 5T0J, 5VHS, 5VFP, 6MSJ, 5T0I

Interactors (52)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17980 PSMC3	5	PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [cytosol] (R-HSA-68774)	0.919	16
UniProt:P62195 PSMC5	2	PSMC5 [nucleoplasm] (R-HSA-174312) PSMC5 [cytosol] (R-HSA-68780)	0.905	14
UniProt:O00233 PSMD9	2	PSMD9 [nucleoplasm] (R-HSA-174321) PSMD9 [cytosol] (R-HSA-68810)	0.904	15
UniProt:P62191 PSMC1	2	PSMC1 [nucleoplasm] (R-HSA-174338) PSMC1 [cytosol] (R-HSA-68768)	0.825	7
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.781	10
UniProt:P35998 PSMC2	5	PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [cytosol] (R-HSA-68771)	0.772	5
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.718	6
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.703	5
UniProt:P51665 PSMD7	5	PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [cytosol] (R-HSA-68806)	0.681	3
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.669	4
UniProt:O00232 PSMD12	5	PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [cytosol] (R-HSA-68792)	0.667	3
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.666	4
UniProt:Q8TAB5 CA216			0.666	4
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.652	3
UniProt:P49720 PSMB3	2	PSMB3 [nucleoplasm] (R-HSA-174341) PSMB3 [cytosol] (R-HSA-68747)	0.638	3
UniProt:Q13200 PSMD2	5	PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.621	3
UniProt:O75832 PSMD10	2	PSMD10 [cytosol] (R-HSA-68788) PSMD10 [nucleoplasm] (R-HSA-174322)	0.564	3
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.557	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:P52655 GTF2A1	2	GTF2A1(275-376) [nucleoplasm] (R-HSA-109768) GTF2A1(1-274) [nucleoplasm] (R-HSA-109767)	0.556	3
UniProt:Q969G3 SMARCE1	1	SMARCE1 [nucleoplasm] (R-HSA-389258)	0.556	3
UniProt:Q6BCY4 CYB5R2	1	CYB5R2 [endoplasmic reticulum membrane] (R-HSA-6806861)	0.556	3
UniProt:O43304 S14L5			0.556	3
UniProt:Q8IYE0-2 CCDC146			0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.556	3
UniProt:P33297	4	PSMC3 [cytosol] (R-SCE-68774) PSMC3 [ficolin-1-rich granule lumen] (R-SCE-6800429) PSMC3 [extracellular region] (R-SCE-6806496) PSMC3 [secretory granule lumen] (R-SCE-6800917)	0.556	3
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189)	0.556	3
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.556	5
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:Q9UNM6 PSMD13	5	PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [cytosol] (R-HSA-68794)	0.553	2
UniProt:Q15008 PSMD6	5	PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [cytosol] (R-HSA-68804)	0.553	2
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.553	2
UniProt:P55036 PSMD4	2	PSMD4 [nucleoplasm] (R-HSA-174330) PSMD4 [cytosol] (R-HSA-68800)	0.553	2
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.528	2
UniProt:Q16401 PSMD5	2	PSMD5 [nucleoplasm] (R-HSA-174346) PSMD5 [cytosol] (R-HSA-68802)	0.527	2
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.527	3
UniProt:P28070 PSMB4	2	PSMB4 [nucleoplasm] (R-HSA-174343) PSMB4 [cytosol] (R-HSA-68750)	0.495	2
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.495	2
UniProt:Q99436 PSMB7	5	PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [cytosol] (R-HSA-68759)	0.495	2
UniProt:P28074 PSMB5	2	PSMB5 [nucleoplasm] (R-HSA-174344) PSMB5 [cytosol] (R-HSA-68753)	0.495	2
UniProt:P28072 PSMB6	2	PSMB6 [nucleoplasm] (R-HSA-174342) PSMB6 [cytosol] (R-HSA-68756)	0.495	2
UniProt:P49721 PSMB2	2	PSMB2 [nucleoplasm] (R-HSA-174335) PSMB2 [cytosol] (R-HSA-68744)	0.495	2
UniProt:P20618 PSMB1	5	PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [cytosol] (R-HSA-68738)	0.495	2
UniProt:P28066 PSMA5	5	PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [cytosol] (R-HSA-68732)	0.495	2
UniProt:P25787 PSMA2	5	PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [cytosol] (R-HSA-68726)	0.495	2
UniProt:P25788 PSMA3	2	PSMA3 [nucleoplasm] (R-HSA-174323) PSMA3 [cytosol] (R-HSA-68728)	0.495	2
UniProt:P25789 PSMA4	2	PSMA4 [nucleoplasm] (R-HSA-174324) PSMA4 [cytosol] (R-HSA-68730)	0.495	2
UniProt:P60900 PSMA6	2	PSMA6 [nucleoplasm] (R-HSA-174314) PSMA6 [cytosol] (R-HSA-68734)	0.495	2

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