Reactome | PSMC6 [nucleoplasm]

PSMC6 [nucleoplasm]

Stable Identifier

R-HSA-174319

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S protease regulatory subunit S10B, Proteasome subunit p42, p44, Conserved ATPase domain protein 44, CADp44

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC3:PSMC6 [nucleoplasm] (Homo sapiens)
        
        PSMC6 [nucleoplasm] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC3:PSMC6 [nucleoplasm] (Homo sapiens)
        
        PSMC6 [nucleoplasm] (Homo sapiens)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
        
        Degradation of multiubiquitinated Cdh1 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC3:PSMC6 [nucleoplasm] (Homo sapiens)
        
        PSMC6 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC3:PSMC6 [nucleoplasm] (Homo sapiens)
        
        PSMC6 [nucleoplasm] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC3:PSMC6 [nucleoplasm] (Homo sapiens)
        
        PSMC6 [nucleoplasm] (Homo sapiens)

DNA Replication (Homo sapiens)

- DNA Replication Pre-Initiation (Homo sapiens)
  - Assembly of the pre-replicative complex (Homo sapiens)
    - Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC3:PSMC6 [nucleoplasm] (Homo sapiens)
        
        PSMC6 [nucleoplasm] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Gastrulation (Homo sapiens)
  - Formation of paraxial mesoderm (Homo sapiens)
    - Somitogenesis (Homo sapiens)
      - RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC3:PSMC6 [nucleoplasm] (Homo sapiens)
        
        PSMC6 [nucleoplasm] (Homo sapiens)
        
        TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC3:PSMC6 [nucleoplasm] (Homo sapiens)
        
        PSMC6 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - Regulation of RUNX2 expression and activity (Homo sapiens)
        
        26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC3:PSMC6 [nucleoplasm] (Homo sapiens)
        
        PSMC6 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX3 (Homo sapiens)
      - Regulation of RUNX3 expression and activity (Homo sapiens)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC3:PSMC6 [nucleoplasm] (Homo sapiens)
        
        PSMC6 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Hedgehog (Homo sapiens)
  - Hedgehog 'on' state (Homo sapiens)
    - GLI2,3 are degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC3:PSMC6 [nucleoplasm] (Homo sapiens)
        
        PSMC6 [nucleoplasm] (Homo sapiens)
- Signaling by NOTCH (Homo sapiens)
  - Signaling by NOTCH4 (Homo sapiens)
    - Negative regulation of NOTCH4 signaling (Homo sapiens)
      - Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP base [nucleoplasm] (Homo sapiens)
        
        PSMC3:PSMC6 [nucleoplasm] (Homo sapiens)
        
        PSMC6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62333 PSMC6

Gene Names

PSMC6, SUG2

Chain

chain:1-389

Reference Genes

BioGPS Gene:5706 PSMC6

COSMIC (genes):PSMC6 PSMC6

CTD Gene:5706 PSMC6

dbSNP Gene:5706 PSMC6

ENSEMBL:ENSG00000100519 PSMC6

ENSEMBL_homo_sapiens_GENE:ENSG00000100519.12 PSMC6

HGNC:9553 PSMC6

KEGG Gene (Homo sapiens):5706 PSMC6

Monarch:5706 PSMC6

NCBI Gene:5706 PSMC6

OMIM:602708 PSMC6

UCSC:P62333 PSMC6

Reference Transcript

RefSeq:NM_002806.3 PSMC6

Other Identifiers

11720983_s_at

16784228

201699_PM_at

201699_at

3136120

3136122

3136123

3136124

3136125

3136126

3136127

3136128

3535886

3535889

3535890

3535892

3535896

3535897

3535898

3535899

3535904

3535906

3535907

3535910

3535911

3535914

3535916

3535917

3535918

3535919

3535920

3535921

5706

7974380

8150870

949_s_at

A_23_P128930

A_24_P381625

D78275_at

GE57296

GO:0000166

GO:0000502

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0008540

GO:0016020

GO:0016234

GO:0016787

GO:0016887

GO:0022624

GO:0030163

GO:0030433

GO:0030674

GO:0031597

GO:0036402

GO:0042802

GO:0043161

GO:0043226

GO:0045899

GO:0060090

GO:0065003

GO:0070062

GO:0090261

GO:0140657

GO:1901800

HMNXSV003008240

ILMN_1655316

ILMN_2096759

PH_hs_0029255

TC14000309.hg

g4506214_3p_at

Participates

as a component of

PSMC3:PSMC6 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMC6 [cytosol]

Inferred To

LOC100687259 [nucleoplasm] (Canis familiaris)

Psmc6 [nucleoplasm] (Rattus norvegicus)

Rpt4 [nucleoplasm] (Drosophila melanogaster)

PSMC6 [nucleoplasm] (Bos taurus)

PSMC6 [nucleoplasm] (Caenorhabditis elegans)

PSMC6 [nucleoplasm] (Dictyostelium discoideum)

PSMC6 [nucleoplasm] (Gallus gallus)

PSMC6 [nucleoplasm] (Mus musculus)

PSMC6 [nucleoplasm] (Sus scrofa)

psmc6 [nucleoplasm] (Danio rerio)

psmc6 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_002797.3

OpenTargets

ENSG00000100519

HPA

ENSG00000100519-PSMC6

GeneCards

P62333

Ensembl

ENSP00000401802, ENSG00000100519, ENST00000445930

PRO

P62333

Pharos - Targets

P62333

PDB

5VFT, 5VHS, 5VHN, 5T0C, 5VGZ, 5GJR, 6MSE, 5VFS, 5VHR, 5VHM, 5VHJ, 7QY7, 6MSJ, 5M32, 6MSD, 5VFR, 5VHQ, 5VHI, 5LN3, 5GJQ, 5T0J, 6MSB, 5VFQ, 5VHP, 5T0I, 5VFP, 5VHH, 6MSH, 8CVT, 5L4G, 6MSK, 5VHO, 5T0H, 6WJN, 5VHF, 5T0G, 5VFU, 6MSG

Interactors (58)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17980 PSMC3	5	PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [cytosol] (R-HSA-68774)	0.95	20
UniProt:P62195 PSMC5	2	PSMC5 [nucleoplasm] (R-HSA-174312) PSMC5 [cytosol] (R-HSA-68780)	0.939	17
UniProt:O00233 PSMD9	1	PSMD9 [cytosol] (R-HSA-68810)	0.939	20
UniProt:P62191 PSMC1	2	PSMC1 [nucleoplasm] (R-HSA-174338) PSMC1 [cytosol] (R-HSA-68768)	0.867	8
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.825	9
UniProt:P35998 PSMC2	5	PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [cytosol] (R-HSA-68771)	0.825	6
UniProt:O00232 PSMD12	5	PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [cytosol] (R-HSA-68792)	0.804	7
UniProt:P49720 PSMB3	2	PSMB3 [nucleoplasm] (R-HSA-174341) PSMB3 [cytosol] (R-HSA-68747)	0.793	7
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.788	6
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.781	10
UniProt:Q13200 PSMD2	5	PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.775	6
UniProt:P51665 PSMD7	5	PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [cytosol] (R-HSA-68806)	0.745	4
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.745	5
UniProt:Q9UNM6 PSMD13	5	PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [cytosol] (R-HSA-68794)	0.745	5
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.744	7
UniProt:P49721 PSMB2	2	PSMB2 [nucleoplasm] (R-HSA-174335) PSMB2 [cytosol] (R-HSA-68744)	0.728	4
UniProt:P25787 PSMA2	5	PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [cytosol] (R-HSA-68726)	0.728	4
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.718	6
UniProt:Q15008 PSMD6	5	PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [cytosol] (R-HSA-68804)	0.667	3
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.666	4
UniProt:Q8TAB5 CA216			0.666	4
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.652	3
UniProt:O43242 PSMD3	5	PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [cytosol] (R-HSA-68798)	0.648	4
UniProt:Q16186 ADRM1	2	ADRM1 [nucleoplasm] (R-HSA-9918361) ADRM1 [cytosol] (R-HSA-5665939)	0.643	5
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.643	4
UniProt:P28070 PSMB4	4	PSMB4(1-45) [cytosol] (R-HSA-9908122) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4 [nucleoplasm] (R-HSA-174343) PSMB4 [cytosol] (R-HSA-68750)	0.638	3
UniProt:Q99436 PSMB7	7	PSMB7(1-43) [cytosol] (R-HSA-9908129) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [cytosol] (R-HSA-68759)	0.638	3
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.638	3
UniProt:P28066 PSMA5	5	PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [cytosol] (R-HSA-68732)	0.638	3
UniProt:P20618 PSMB1	7	PSMB1(1-28) [cytosol] (R-HSA-9908143) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [cytosol] (R-HSA-68738)	0.638	3
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.564	2
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.557	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:P52655 GTF2A1	2	GTF2A1(275-376) [nucleoplasm] (R-HSA-109768) GTF2A1(1-274) [nucleoplasm] (R-HSA-109767)	0.556	3
UniProt:Q969G3 SMARCE1	1	SMARCE1 [nucleoplasm] (R-HSA-389258)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q6BCY4 CYB5R2	1	CYB5R2 [endoplasmic reticulum membrane] (R-HSA-6806861)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3
UniProt:O43304 S14L5			0.556	3
UniProt:Q8IYE0-2 CCDC146			0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:P33297	4	PSMC3 [cytosol] (R-SCE-68774) PSMC3 [ficolin-1-rich granule lumen] (R-SCE-6800429) PSMC3 [extracellular region] (R-SCE-6806496) PSMC3 [secretory granule lumen] (R-SCE-6800917)	0.556	3
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.556	5
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.553	2
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.528	2
UniProt:O00231 PSMD11	5	PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [cytosol] (R-HSA-68790)	0.528	2
UniProt:Q53HC0 CCD92			0.527	3
UniProt:P28065 PSMB9	3	PSMB9(1-20) [cytosol] (R-HSA-9908132) PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136)	0.527	4
UniProt:P25788 PSMA3	2	PSMA3 [nucleoplasm] (R-HSA-174323) PSMA3 [cytosol] (R-HSA-68728)	0.495	2
UniProt:P28074 PSMB5	4	PSMB5(1-59) [cytosol] (R-HSA-9908134) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5 [nucleoplasm] (R-HSA-174344) PSMB5 [cytosol] (R-HSA-68753)	0.495	2
UniProt:P60900 PSMA6	2	PSMA6 [nucleoplasm] (R-HSA-174314) PSMA6 [cytosol] (R-HSA-68734)	0.495	2
UniProt:P25789 PSMA4	2	PSMA4 [nucleoplasm] (R-HSA-174324) PSMA4 [cytosol] (R-HSA-68730)	0.495	2
UniProt:P28072 PSMB6	4	PSMB6(1-34) [cytosol] (R-HSA-9908141) pro-PSMB6 [cytosol] (R-HSA-9908130) PSMB6 [nucleoplasm] (R-HSA-174342) PSMB6 [cytosol] (R-HSA-68756)	0.495	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	14

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