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PSMC6 [nucleoplasm]
Stable Identifier
R-HSA-174319
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
26S protease regulatory subunit S10B, Proteasome subunit p42, p44, Conserved ATPase domain protein 44, CADp44
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62333 PSMC6
Gene Names
PSMC6, SUG2
Chain
chain:1-389
Reference Genes
BioGPS Gene:5706 PSMC6
COSMIC (genes):PSMC6 PSMC6
CTD Gene:5706 PSMC6
dbSNP Gene:5706 PSMC6
ENSEMBL:ENSG00000100519 PSMC6
HGNC:9553 PSMC6
KEGG Gene (Homo sapiens):5706 PSMC6
Monarch:5706 PSMC6
NCBI Gene:5706 PSMC6
OMIM:602708 PSMC6
UCSC:P62333 PSMC6
Reference Transcript
RefSeq:NM_002806.3 PSMC6
Other Identifiers
0006020059
11720983_s_at
16784228
201699_at
3136120
3136122
3136123
3136124
3136125
3136126
3136127
3136128
3535886
3535889
3535890
3535892
3535896
3535897
3535898
3535899
3535904
3535906
3535907
3535910
3535911
3535914
3535916
3535917
3535918
3535919
3535920
3535921
5706
7974380
8150870
949_s_at
A_23_P128930
A_24_P381625
D78275_at
GE57296
GO:0000165
GO:0000166
GO:0000209
GO:0000278
GO:0000502
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006511
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0008540
GO:0009056
GO:0009058
GO:0010972
GO:0016020
GO:0016234
GO:0016579
GO:0016787
GO:0016887
GO:0022607
GO:0022624
GO:0030154
GO:0030163
GO:0030433
GO:0030674
GO:0031145
GO:0031146
GO:0031597
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0036388
GO:0036402
GO:0038061
GO:0038095
GO:0042802
GO:0043161
GO:0043167
GO:0043226
GO:0043488
GO:0043687
GO:0044281
GO:0045899
GO:0048856
GO:0050852
GO:0055085
GO:0060071
GO:0061418
GO:0065003
GO:0070062
GO:0070498
GO:0090090
GO:0090261
GO:0090263
GO:1901800
GO:1901990
GO:1902036
HMNXSV003008240
ILMN_1655316
ILMN_2096759
PH_hs_0029255
TC14000309.hg
g4506214_3p_at
Participates
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMC6 [cytosol]
Inferred To
LOC100687259 [nucleoplasm]
(Canis familiaris)
Psmc6 [nucleoplasm]
(Mus musculus)
Psmc6 [nucleoplasm]
(Rattus norvegicus)
psmC6 [nucleoplasm]
(Dictyostelium discoideum)
rpt-4 [nucleoplasm]
(Caenorhabditis elegans)
rpt4 [nucleoplasm]
(Schizosaccharomyces pombe)
Homologues of PSMC6 [nucleoplasm]
(Canis familiaris)
Rpt4 [nucleoplasm]
(Drosophila melanogaster)
PSMC6 [nucleoplasm]
(Canis familiaris)
PSMC6 [nucleoplasm]
(Sus scrofa)
psmc6 [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_002797.3
OpenTargets
ENSG00000100519
HPA
ENSG00000100519-PSMC6
GeneCards
P62333
Ensembl
ENSP00000401802
,
ENSG00000100519
,
ENST00000445930
PRO
P62333
Pharos - Targets
P62333
GlyGen
P62333
PDB
5VHR
,
5VFP
,
5T0H
,
6MSK
,
5T0G
,
5VHQ
,
5GJQ
,
6MSH
,
5VFQ
,
5T0I
,
5VHS
,
6WJN
,
6MSJ
,
5VGZ
,
6MSG
,
5VHN
,
6MSD
,
5VHP
,
5LN3
,
5T0C
,
5M32
,
6MSE
,
5VHO
,
5L4G
,
5VHJ
,
6MSB
,
5VHI
,
5VFU
,
5VHM
,
5VFS
,
5VHF
,
5VFR
,
5T0J
,
5GJR
,
5VHH
,
5VFT
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.781
10
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.718
6
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.669
4
UniProt:P59595 N
9
N [cytosol]
(R-COV-9683625)
p-S177-N [cytosol]
(R-COV-9683754)
ADPr-p-S177-N [cytosol]
(R-COV-9686058)
SUMO1-K62-ADPr-p-S177-N [cytosol]
(R-COV-9682916)
SUMO1-K62-ADPr-p-S177-N [viral capsid]
(R-COV-9685478)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9683641)
N [plasma membrane]
(R-COV-9683611)
SUMO1-K62-ADPr-p-S177-N [nucleolus]
(R-COV-9683730)
SUMO1-K62-ADPr-p-S177-N [plasma membrane]
(R-COV-9686063)
0.557
3
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.556
5
UniProt:Q14957 GRIN2C
3
GRIN2C [plasma membrane]
(R-HSA-419560)
GRIN2C [endoplasmic reticulum membrane]
(R-HSA-9609761)
p-Y-GRIN2C [plasma membrane]
(R-HSA-9612189)
0.556
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P04792 HSPB1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:Q13895 BYSL
2
BYSL [nucleoplasm]
(R-HSA-6791526)
BYSL [cytosol]
(R-HSA-6791518)
0.556
3
UniProt:O00487 PSMD14
5
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [cytosol]
(R-HSA-68722)
0.528
2
UniProt:Q16186 ADRM1
1
ADRM1 [cytosol]
(R-HSA-5665939)
0.527
3
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