Reactome | PSMC6 [nucleoplasm]

PSMC6 [nucleoplasm]

Stable Identifier

R-HSA-174319

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S protease regulatory subunit S10B, Proteasome subunit p42, p44, Conserved ATPase domain protein 44, CADp44

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMC6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62333 PSMC6

Gene Names

PSMC6, SUG2

Chain

chain:1-389

Reference Genes

BioGPS Gene:5706 PSMC6

COSMIC (genes):PSMC6 PSMC6

CTD Gene:5706 PSMC6

dbSNP Gene:5706 PSMC6

ENSEMBL:ENSG00000100519 PSMC6

HGNC:9553 PSMC6

KEGG Gene (Homo sapiens):5706 PSMC6

Monarch:5706 PSMC6

NCBI Gene:5706 PSMC6

OMIM:602708 PSMC6

UCSC:P62333 PSMC6

Reference Transcript

RefSeq:NM_002806.3 PSMC6

Other Identifiers

0006020059

11720983_s_at

16784228

201699_at

3136120

3136122

3136123

3136124

3136125

3136126

3136127

3136128

3535886

3535889

3535890

3535892

3535896

3535897

3535898

3535899

3535904

3535906

3535907

3535910

3535911

3535914

3535916

3535917

3535918

3535919

3535920

3535921

5706

7974380

8150870

949_s_at

A_23_P128930

A_24_P381625

D78275_at

GE57296

GO:0000165

GO:0000166

GO:0000209

GO:0000278

GO:0000502

GO:0002223

GO:0002376

GO:0002479

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006464

GO:0006511

GO:0006520

GO:0006521

GO:0006810

GO:0006950

GO:0007049

GO:0007165

GO:0007267

GO:0008150

GO:0008540

GO:0009056

GO:0009058

GO:0010972

GO:0016020

GO:0016234

GO:0016579

GO:0016787

GO:0016887

GO:0022607

GO:0022624

GO:0030154

GO:0030163

GO:0030433

GO:0030674

GO:0031145

GO:0031146

GO:0031597

GO:0032991

GO:0033209

GO:0034641

GO:0034655

GO:0036388

GO:0036402

GO:0038061

GO:0038095

GO:0042802

GO:0043161

GO:0043167

GO:0043226

GO:0043488

GO:0043687

GO:0044281

GO:0045899

GO:0048856

GO:0050852

GO:0055085

GO:0060071

GO:0061418

GO:0065003

GO:0070062

GO:0070498

GO:0090090

GO:0090261

GO:0090263

GO:1901800

GO:1901990

GO:1902036

HMNXSV003008240

ILMN_1655316

ILMN_2096759

PH_hs_0029255

TC14000309.hg

g4506214_3p_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMC6 [cytosol]

Inferred To

LOC100687259 [nucleoplasm] (Canis familiaris)

Psmc6 [nucleoplasm] (Mus musculus)

Psmc6 [nucleoplasm] (Rattus norvegicus)

psmC6 [nucleoplasm] (Dictyostelium discoideum)

rpt-4 [nucleoplasm] (Caenorhabditis elegans)

rpt4 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of PSMC6 [nucleoplasm] (Canis familiaris)

Rpt4 [nucleoplasm] (Drosophila melanogaster)

PSMC6 [nucleoplasm] (Canis familiaris)

PSMC6 [nucleoplasm] (Sus scrofa)

psmc6 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_002797.3

OpenTargets

ENSG00000100519

HPA

ENSG00000100519-PSMC6

GeneCards

P62333

Ensembl

ENSP00000401802, ENSG00000100519, ENST00000445930

PRO

P62333

Pharos - Targets

P62333

GlyGen

P62333

PDB

5VHR, 5VFP, 5T0H, 6MSK, 5T0G, 5VHQ, 5GJQ, 6MSH, 5VFQ, 5T0I, 5VHS, 6WJN, 6MSJ, 5VGZ, 6MSG, 5VHN, 6MSD, 5VHP, 5LN3, 5T0C, 5M32, 6MSE, 5VHO, 5L4G, 5VHJ, 6MSB, 5VHI, 5VFU, 5VHM, 5VFS, 5VHF, 5VFR, 5T0J, 5GJR, 5VHH, 5VFT

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.781	10
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.718	6
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.669	4
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.557	3
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.556	5
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.528	2
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.527	3