Reactome | PSMA3 [nucleoplasm]

PSMA3 [nucleoplasm]

Stable Identifier

R-HSA-174323

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome subunit alpha type 3 , Proteasome component C8, Macropain subunit C8, Multicatalytic endopeptidase complex subunit C8

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMA3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25788 PSMA3

Gene Names

PSMA3, HC8, PSC8

Chain

initiator methionine:1, chain:2-255

Reference Genes

BioGPS Gene:5684 PSMA3

COSMIC (genes):PSMA3 PSMA3

CTD Gene:5684 PSMA3

dbSNP Gene:5684 PSMA3

ENSEMBL:ENSG00000100567.13 PSMA3

HGNC:9532 PSMA3

KEGG Gene (Homo sapiens):5684 PSMA3

Monarch:5684 PSMA3

NCBI Gene:5684 PSMA3

OMIM:176843 PSMA3

OMIM:176845 PSMA3

UCSC:P25788 PSMA3

Reference Transcript

Other Identifiers

0001580519

11715835_a_at

11715836_x_at

1448_at

16784642

201532_PM_at

201532_at

3537757

3537758

3537765

3537767

3537769

3537771

3537776

3537778

3537784

3537788

3537790

3537794

3537795

3537796

5684

7974603

A_23_P140301

D00762_at

GE61594

GO:0000502

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0006511

GO:0010498

GO:0019773

GO:0030163

GO:0031625

GO:0032991

GO:0043161

GO:0043226

GO:0045202

GO:0051603

GO:0052548

GO:0070062

HMNXSV003050350

ILMN_1694931

ILMN_2318011

ILMN_2387553

TC14000346.hg

TC14001708.hg

g4506182_3p_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMA3 [cytosol]

Inferred To

psmA3 [nucleoplasm] (Dictyostelium discoideum)

Proteasome subunit alpha type-3 [nucleoplasm] (Mus musculus)

Psma3 [nucleoplasm] (Rattus norvegicus)

PSMA3 [nucleoplasm] (Bos taurus)

PSMA3 [nucleoplasm] (Canis familiaris)

PSMA3 [nucleoplasm] (Gallus gallus)

PSMA3 [nucleoplasm] (Sus scrofa)

psma3 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of PSMA3 [nucleoplasm] (Caenorhabditis elegans)

Prosalpha7 [nucleoplasm] (Drosophila melanogaster)

zgc:114044 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_687033.1, NP_002779.1

OpenTargets

ENSG00000100567

GeneCards

P25788

HPA

ENSG00000100567-PSMA3

Ensembl

ENSG00000100567, ENSP00000216455, ENST00000412908, ENST00000216455, ENSP00000390491

PRO

P25788

Pharos - Targets

P25788

Orphanet

24829

PDB

5T0C, 5LF4, 6MSG, 7V5M, 5GJR, 4R67, 6MSK, 5LE5, 5LF3, 6MSD, 5DSV, 6MSB, 6MSJ, 5LEX, 5L4G, 6WJD, 5T0H, 5VFQ, 6AVO, 5LF0, 6E5B, 5LF6, 7PG9, 5VFP, 7LXV, 5T0G, 5VFT, 6MSE, 5T0J, 5VFO, 5LEZ, 5LN3, 6REY, 6WJN, 5GJQ, 6RGQ, 5T0I, 7V5G, 7NHT, 5VFS, 5LEY, 5M32, 6KWY, 4R3O, 5LF1, 7AWE, 5LF7, 7E55, 5VFR, 6XMJ, 5VFU, 5A0Q, 6MSH, 6R70, 7B12

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14565 DMC1	1	DMC1 [nucleoplasm] (R-HSA-912490)	0.781	7
UniProt:P23769 GATA2	1	GATA2 [nucleoplasm] (R-HSA-996735)	0.666	4
UniProt:Q9BUF7 CRB3	1	CRB3 [plasma membrane] (R-HSA-420009)	0.556	3
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.556	3
UniProt:Q9BTD8 RBM42	1	RBM42 [nucleoplasm] (R-HSA-9769526)	0.556	3
UniProt:Q12846 STX4	4	STX4 [plasma membrane] (R-HSA-181519) STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.556	3
UniProt:Q15637 SF1	1	SF1 [nucleoplasm] (R-HSA-8865928)	0.556	3
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.556	3
UniProt:Q96PC5 MIA2	1	MIA2 [endoplasmic reticulum membrane] (R-HSA-9637821)	0.556	3
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.556	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.527	2
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P29590 PML	5	polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) PML [cytosol] (R-HSA-5624327)	0.508	2
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.495	2
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.488	2