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PSMA3 [nucleoplasm]
Stable Identifier
R-HSA-174323
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit alpha type 3 , Proteasome component C8, Macropain subunit C8, Multicatalytic endopeptidase complex subunit C8
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25788 PSMA3
Gene Names
PSMA3, HC8, PSC8
Chain
initiator methionine:, chain:2-255
Reference Genes
BioGPS Gene:5684 PSMA3
COSMIC (genes):PSMA3 PSMA3
CTD Gene:5684 PSMA3
dbSNP Gene:5684 PSMA3
ENSEMBL:ENSG00000100567 PSMA3
ENSEMBL_homo_sapiens_GENE:ENSG00000100567.13 PSMA3
HGNC:9532 PSMA3
KEGG Gene (Homo sapiens):5684 PSMA3
Monarch:5684 PSMA3
NCBI Gene:5684 PSMA3
OMIM:176843 PSMA3
OMIM:176845 PSMA3
UCSC:P25788 PSMA3
Reference Transcript
RefSeq:NM_002788.3 PSMA3
RefSeq:NM_152132.2 PSMA3
Other Identifiers
11715835_a_at
11715836_x_at
1448_at
16784642
201532_PM_at
201532_at
3537757
3537758
3537765
3537767
3537769
3537771
3537776
3537778
3537784
3537788
3537790
3537794
3537795
3537796
5684
7974603
A_23_P140301
D00762_at
GE61594
GO:0000502
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0006511
GO:0010498
GO:0019773
GO:0030163
GO:0031625
GO:0043161
GO:0043226
GO:0045202
GO:0051603
GO:0052548
GO:0070062
HMNXSV003050350
ILMN_2318011
ILMN_2387553
TC14000346.hg
TC14001708.hg
g4506182_3p_at
Participates
as a component of
20S CP outer ring [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMA3 [cytosol]
Inferred To
psmA3 [nucleoplasm]
(Dictyostelium discoideum)
Psma3 [nucleoplasm]
(Mus musculus)
Psma3 [nucleoplasm]
(Rattus norvegicus)
PSMA3 [nucleoplasm]
(Bos taurus)
PSMA3 [nucleoplasm]
(Canis familiaris)
PSMA3 [nucleoplasm]
(Gallus gallus)
PSMA3 [nucleoplasm]
(Sus scrofa)
psma3 [nucleoplasm]
(Danio rerio)
psma3 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of PSMA3 [nucleoplasm]
(Caenorhabditis elegans)
Prosalpha7 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_002779.1
,
NP_687033.1
OpenTargets
ENSG00000100567
GeneCards
P25788
HPA
ENSG00000100567-PSMA3
Ensembl
ENST00000412908
,
ENST00000216455
,
ENSP00000216455
,
ENSG00000100567
,
ENSP00000390491
PRO
P25788
Pharos - Targets
P25788
PDB
6MSK
,
5VFQ
,
5LF1
,
7QXU
,
7W3J
,
5T0J
,
5VFP
,
7LXV
,
7NAO
,
7W3A
,
5LF0
,
5DSV
,
5T0I
,
5VFO
,
5LF6
,
7QYB
,
7W3H
,
8QYN
,
7AWE
,
7NHT
,
7W39
,
7W3I
,
7W38
,
7W3F
,
5LF7
,
5T0C
,
7QYA
,
5M32
,
8CXB
,
6RGQ
,
6MSB
,
7NAP
,
8QYS
,
5T0H
,
6MSD
,
6AVO
,
8QZ9
,
7QY7
,
7NAQ
,
5GJR
,
5VFU
,
7E55
,
8BZL
,
7W3K
,
7NAN
,
5L4G
,
5LEZ
,
5VFR
,
6WJD
,
4R67
,
7PG9
,
6R70
,
5LEY
,
8QYO
,
5VFS
,
6MSH
,
5LF4
,
7QXN
,
7V5M
,
8CVS
,
7W37
,
8QYL
,
6MSJ
,
8UD9
,
6XMJ
,
5LF3
,
7QXP
,
8CVT
,
8QYM
,
5LE5
,
6MSE
,
5GJQ
,
6MSG
,
8CVR
,
5LN3
,
7W3G
,
6REY
,
7V5G
,
8QYJ
,
7W3B
,
4R3O
,
5LEX
,
5VFT
,
7QXW
,
5A0Q
,
7W3M
,
6E5B
,
7B12
,
6WJN
,
6KWY
,
7W3C
,
7QXX
,
5T0G
Interactors (93)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P25786 PSMA1
2
PSMA1 [nucleoplasm]
(R-HSA-174333)
PSMA1 [cytosol]
(R-HSA-68724)
0.951
21
UniProt:P60900 PSMA6
2
PSMA6 [nucleoplasm]
(R-HSA-174314)
PSMA6 [cytosol]
(R-HSA-68734)
0.844
10
UniProt:O14818 PSMA7
2
PSMA7 [nucleoplasm]
(R-HSA-174351)
PSMA7 [cytosol]
(R-HSA-68736)
0.835
7
UniProt:Q14565 DMC1
1
DMC1 [nucleoplasm]
(R-HSA-912490)
0.781
7
UniProt:Q8N895 ZN366
0.742
5
UniProt:P25787 PSMA2
5
PSMA2 [secretory granule lumen]
(R-HSA-6803329)
PSMA2 [extracellular region]
(R-HSA-6806506)
PSMA2 [ficolin-1-rich granule lumen]
(R-HSA-6803285)
PSMA2 [nucleoplasm]
(R-HSA-174345)
PSMA2 [cytosol]
(R-HSA-68726)
0.738
6
UniProt:Q9Y3I1 FBXO7
1
FBXO7 [cytosol]
(R-HSA-8862627)
0.718
6
UniProt:P28070 PSMB4
4
PSMB4(1-45) [cytosol]
(R-HSA-9908122)
pro-PSMB4 [cytosol]
(R-HSA-9908138)
PSMB4 [nucleoplasm]
(R-HSA-174343)
PSMB4 [cytosol]
(R-HSA-68750)
0.666
5
UniProt:Q66K41 Z385C
0.666
4
UniProt:Q6IPM2 IQCE
1
IQCE [cilium]
(R-HSA-5633055)
0.666
4
UniProt:Q9BTD8 RBM42
1
RBM42 [nucleoplasm]
(R-HSA-9769526)
0.666
4
UniProt:P23769 GATA2
1
GATA2 [nucleoplasm]
(R-HSA-996735)
0.666
4
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.643
4
UniProt:P25789 PSMA4
2
PSMA4 [nucleoplasm]
(R-HSA-174324)
PSMA4 [cytosol]
(R-HSA-68730)
0.573
4
UniProt:Q15008 PSMD6
5
PSMD6 [secretory granule lumen]
(R-HSA-6801036)
PSMD6 [extracellular region]
(R-HSA-6806486)
PSMD6 [ficolin-1-rich granule lumen]
(R-HSA-6800440)
PSMD6 [nucleoplasm]
(R-HSA-174316)
PSMD6 [cytosol]
(R-HSA-68804)
0.564
2
UniProt:Q7KZQ1 Q7KZQ1
0.556
3
UniProt:Q8N2R0 OSR2
0.556
3
UniProt:Q9HAA0 Q9HAA0
0.556
3
UniProt:Q9NZ81 PRR13
0.556
3
IntAct:EBI-10202556 257000
0.556
3
IntAct:EBI-10202517 3845
0.556
3
UniProt:Q12846 STX4
4
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.556
3
UniProt:Q6RVD6 SPAT8
0.556
3
UniProt:Q7Z3D6 GLUCM
0.556
3
UniProt:Q96CW7 Q96CW7
0.556
3
UniProt:Q9BTL3 RAMAC
0.556
3
UniProt:Q6NUJ5 PWP2B
0.556
3
UniProt:O43251 RBFOX2
1
RBFOX2 [nucleoplasm]
(R-HSA-6803504)
0.556
3
UniProt:P09228 CYTT
0.556
3
UniProt:Q7L9D0 Q7L9D0
0.556
3
UniProt:Q86UY5 FAM83A
1
FAM83A [cytosol]
(R-HSA-9851391)
0.556
3
UniProt:Q8N779 Q8N779
0.556
3
UniProt:Q3LI72 KRTAP19-5
1
KRTAP19-5 [cytosol]
(R-HSA-6810300)
0.556
3
UniProt:Q86TB9 PATL1
1
PATL1 [cytosol]
(R-HSA-2028617)
0.556
3
UniProt:Q9NRJ3 CCL28
1
CCL28 [extracellular region]
(R-HSA-373300)
0.556
3
UniProt:Q8N7Y1 KIAS3
0.556
3
UniProt:Q9NQL9 DMRT3
0.556
3
IntAct:EBI-10202543 129807
0.556
3
UniProt:Q9Y4B4 ARIP4
0.556
3
UniProt:Q6UWL6 KIRREL2
1
KIRREL2 [plasma membrane]
(R-HSA-936066)
0.556
3
UniProt:Q14D33 RTP5
0.556
3
IntAct:EBI-10202502 1535
0.556
3
UniProt:Q9H3S7 PTPN23
1
PTPN23 [nucleoplasm]
(R-HSA-9008924)
0.556
3
UniProt:Q9H8Y8 GORASP2
2
GORASP2 [Golgi membrane]
(R-HSA-2422385)
p-T222,T225-GORASP2 [Golgi membrane]
(R-HSA-2422965)
0.556
3
UniProt:Q5JPT6 Q5JPT6
0.556
3
UniProt:Q96D16 Q96D16
0.556
3
UniProt:Q6PEX3 KRTAP26-1
1
KRTAP26-1 [cytosol]
(R-HSA-6810244)
0.556
3
UniProt:Q9H6H2 Q9H6H2
0.556
3
UniProt:Q66K80 RUAS1
0.556
3
UniProt:Q96HZ7 URAS1
0.556
3
UniProt:P79522 PRR3
0.556
3
UniProt:Q5TAL4 Q5TAL4
0.556
3
UniProt:Q8IUC2 KRTAP8-1
1
KRTAP8-1 [cytosol]
(R-HSA-6810288)
0.556
3
UniProt:A0A0S2Z5X4 A0A0S2Z5X4
0.556
3
UniProt:Q58A44 PCOTH
0.556
3
IntAct:EBI-10202530 284276
0.556
3
UniProt:P14678-2 SNRPB
0.556
3
UniProt:P16860 ANFB
0.556
3
UniProt:Q14CW7 Q14CW7
0.556
3
UniProt:O95561 CA105
0.556
3
IntAct:EBI-10202577 83719
0.556
3
UniProt:O95202 LETM1
2
LETM1 [endoplasmic reticulum membrane]
(R-HSA-9714759)
LETM1 [mitochondrial inner membrane]
(R-HSA-8949702)
0.556
3
UniProt:hCG_2003792 A0A024R5S0
0.556
3
UniProt:Q14847 LASP1
0.556
3
IntAct:EBI-10188417 1021
0.556
3
UniProt:Q8TBN0 RAB3IL1
1
RAB3IL1 [cytosol]
(R-HSA-8875296)
0.556
3
UniProt:Q9NWL9 Q9NWL9
0.556
3
UniProt:Q9H8E5 Q9H8E5
0.556
3
UniProt:Q8N0U1 Q8N0U1
0.556
3
UniProt:A5D8V6 VPS37C
1
VPS37C [endosome membrane]
(R-HSA-184438)
0.556
3
UniProt:Q8NAJ2 CI106
0.556
3
UniProt:B2R550 B2R550
0.556
3
UniProt:P48146 NPBWR2
1
NPBWR2 [plasma membrane]
(R-HSA-374797)
0.556
3
UniProt:Q96MZ4 F218A
0.556
3
UniProt:Q8ND83 SLAI1
0.556
3
UniProt:Q5W150 YT011
0.556
3
UniProt:P27449 ATP6V0C
7
ATP6V0C [endosome membrane]
(R-HSA-912591)
ATP6V0C [phagocytic vesicle membrane]
(R-HSA-1222603)
ATP6V0C [tertiary granule membrane]
(R-HSA-6800991)
ATP6V0C [plasma membrane]
(R-HSA-6806254)
ATP6V0C [azurophil granule membrane]
(R-HSA-6799363)
ATP6V0C [ficolin-1-rich granule membrane]
(R-HSA-6800908)
ATP6V0C [lysosomal membrane]
(R-HSA-9640194)
0.556
3
UniProt:O43752 STX6
2
STX6 [trans-Golgi network membrane]
(R-HSA-6811007)
STX6 [Golgi membrane]
(R-HSA-6811004)
0.556
3
UniProt:Q15637 SF1
1
SF1 [nucleoplasm]
(R-HSA-8865928)
0.556
3
UniProt:P23771 GATA3
2
GATA3 [nucleoplasm]
(R-HSA-996768)
PolyUb-GATA3 [nucleoplasm]
(R-HSA-6783009)
0.556
3
UniProt:Q96PC5 MIA2
1
MIA2 [endoplasmic reticulum membrane]
(R-HSA-9637821)
0.556
3
UniProt:Q8WVV5 BTN2A2
1
BTN2A2 [plasma membrane]
(R-HSA-8851047)
0.556
3
UniProt:Q9BUF7 CRB3
1
CRB3 [plasma membrane]
(R-HSA-420009)
0.556
3
UniProt:P25788 PSMA3
2
PSMA3 [nucleoplasm]
(R-HSA-174323)
PSMA3 [cytosol]
(R-HSA-68728)
0.553
2
UniProt:P28066 PSMA5
5
PSMA5 [secretory granule lumen]
(R-HSA-6803316)
PSMA5 [extracellular region]
(R-HSA-6806459)
PSMA5 [ficolin-1-rich granule lumen]
(R-HSA-6803328)
PSMA5 [nucleoplasm]
(R-HSA-174340)
PSMA5 [cytosol]
(R-HSA-68732)
0.527
4
UniProt:P49721 PSMB2
2
PSMB2 [nucleoplasm]
(R-HSA-174335)
PSMB2 [cytosol]
(R-HSA-68744)
0.527
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P20618 PSMB1
7
PSMB1(1-28) [cytosol]
(R-HSA-9908143)
pro-PSMB1 [cytosol]
(R-HSA-9908139)
PSMB1 [secretory granule lumen]
(R-HSA-6803287)
PSMB1 [extracellular region]
(R-HSA-6806477)
PSMB1 [ficolin-1-rich granule lumen]
(R-HSA-6803340)
PSMB1 [nucleoplasm]
(R-HSA-174347)
PSMB1 [cytosol]
(R-HSA-68738)
0.527
3
UniProt:P28065 PSMB9
3
PSMB9(1-20) [cytosol]
(R-HSA-9908132)
PSMB9 [cytosol]
(R-HSA-68765)
pro-PSMB9 [cytosol]
(R-HSA-9908136)
0.527
4
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.527
2
UniProt:P29590 PML
5
polySUMO3-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000386)
polySUMO2-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000423)
monoSUMO1-K65,160,490-PML [nucleoplasm]
(R-HSA-3000440)
PML [nucleoplasm]
(R-HSA-1031706)
PML [cytosol]
(R-HSA-5624327)
0.508
2
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.495
2
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.488
2
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