Reactome | PSMD13 [nucleoplasm]

PSMD13 [nucleoplasm]

Stable Identifier

R-HSA-174326

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S proteasome non-ATPase regulatory subunit 13, 26S proteasome regulatory subunit S11, 26S proteasome regulatory subunit p40.5

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD13 [nucleoplasm] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD13 [nucleoplasm] (Homo sapiens)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
        
        Degradation of multiubiquitinated Cdh1 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD13 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD13 [nucleoplasm] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD13 [nucleoplasm] (Homo sapiens)

DNA Replication (Homo sapiens)

- DNA Replication Pre-Initiation (Homo sapiens)
  - Assembly of the pre-replicative complex (Homo sapiens)
    - Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD13 [nucleoplasm] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Gastrulation (Homo sapiens)
  - Formation of paraxial mesoderm (Homo sapiens)
    - Somitogenesis (Homo sapiens)
      - RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD13 [nucleoplasm] (Homo sapiens)
        
        TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD13 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - Regulation of RUNX2 expression and activity (Homo sapiens)
        
        26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD13 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX3 (Homo sapiens)
      - Regulation of RUNX3 expression and activity (Homo sapiens)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD13 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Hedgehog (Homo sapiens)
  - Hedgehog 'on' state (Homo sapiens)
    - GLI2,3 are degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD13 [nucleoplasm] (Homo sapiens)
- Signaling by NOTCH (Homo sapiens)
  - Signaling by NOTCH4 (Homo sapiens)
    - Negative regulation of NOTCH4 signaling (Homo sapiens)
      - Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD13 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UNM6 PSMD13

Gene Names

PSMD13

Chain

chain:1-376

Reference Genes

BioGPS Gene:5719 PSMD13

COSMIC (genes):PSMD13 PSMD13

CTD Gene:5719 PSMD13

dbSNP Gene:5719 PSMD13

ENSEMBL:ENSG00000185627 PSMD13

ENSEMBL_homo_sapiens_GENE:ENSG00000185627.19 PSMD13

HGNC:9558 PSMD13

KEGG Gene (Homo sapiens):5719 PSMD13

Monarch:5719 PSMD13

NCBI Gene:5719 PSMD13

OMIM:603481 PSMD13

UCSC:Q9UNM6 PSMD13

Reference Transcript

Other Identifiers

11719927_a_at

11741771_a_at

11756188_x_at

16720006

201232_PM_s_at

201232_s_at

201233_PM_at

201233_at

32211_at

3315550

3315551

3315552

3315554

3315555

3315556

3315557

3315558

3315559

3315562

3315564

3315567

3315572

3315574

3315576

3315577

5719

7937287

A_23_P75889

GE81196

GO:0000502

GO:0005198

GO:0005576

GO:0005634

GO:0005654

GO:0005829

GO:0005838

GO:0006511

GO:0007127

GO:0008541

GO:0016020

GO:0022414

GO:0022624

GO:0030163

GO:0031410

GO:0034774

GO:0043161

GO:0043226

GO:0140013

GO:1904813

HMNXSV003050587

ILMN_1704404

ILMN_2342121

PH_hs_0014359

TC11000006.hg

TC11002481.hg

g4506222_3p_s_at

Participates

as a component of

PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMD13 [secretory granule lumen]

PSMD13 [extracellular region]

PSMD13 [ficolin-1-rich granule lumen]

PSMD13 [cytosol]

Inferred To

Psmd13 [nucleoplasm] (Mus musculus)

Psmd13 [nucleoplasm] (Rattus norvegicus)

psmD13 [nucleoplasm] (Dictyostelium discoideum)

Rpn9 [nucleoplasm] (Drosophila melanogaster)

PSMD13 [nucleoplasm] (Bos taurus)

PSMD13 [nucleoplasm] (Canis familiaris)

PSMD13 [nucleoplasm] (Gallus gallus)

PSMD13 [nucleoplasm] (Sus scrofa)

psmd13 [nucleoplasm] (Danio rerio)

psmd13 [nucleoplasm] (Xenopus tropicalis)

rpn-9 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002808.3, NP_787128.2

OpenTargets

ENSG00000185627

HPA

ENSG00000185627-PSMD13

GeneCards

Q9UNM6

Ensembl

ENSP00000436186, ENST00000532097, ENSG00000185627, ENSP00000396937, ENST00000431206

PRO

Q9UNM6

Pharos - Targets

Q9UNM6

PDB

6MSD, 7W3J, 5L4K, 6MSB, 7QXU, 5T0I, 6WJD, 5VFP, 6WJN, 5GJQ, 7W39, 5VHI, 7W3A, 5VHF, 7QXN, 5VFT, 7QXP, 5VFS, 7W3K, 7W3C, 7W3B, 6MSG, 5VGZ, 5VFR, 6MSH, 5T0J, 5VFQ, 7QXW, 7W3M, 7QXX, 5GJR, 7W3F, 6MSJ, 5T0H, 7W37, 6MSK, 7W3G, 5T0G, 7QY7, 8CVT, 5VHS, 7W3H, 7W38, 5M32, 7QYA, 7W3I, 5T0C, 5VFU, 5LN3, 5VHH, 7QYB, 6MSE

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.758	5
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.745	5
UniProt:O00231 PSMD11	5	PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [cytosol] (R-HSA-68790)	0.745	6
UniProt:P62191 PSMC1	2	PSMC1 [nucleoplasm] (R-HSA-174338) PSMC1 [cytosol] (R-HSA-68768)	0.744	5
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.725	6
UniProt:O00232 PSMD12	5	PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [cytosol] (R-HSA-68792)	0.669	5
UniProt:P51665 PSMD7	5	PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [cytosol] (R-HSA-68806)	0.669	4
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.669	6
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.669	4
UniProt:P35998 PSMC2	5	PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [cytosol] (R-HSA-68771)	0.669	5
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.669	4
UniProt:P62195 PSMC5	2	PSMC5 [nucleoplasm] (R-HSA-174312) PSMC5 [cytosol] (R-HSA-68780)	0.669	5
UniProt:Q13200 PSMD2	5	PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.669	5
UniProt:Q15008 PSMD6	5	PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [cytosol] (R-HSA-68804)	0.669	6
UniProt:O43242 PSMD3	5	PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [cytosol] (R-HSA-68798)	0.669	5
UniProt:P17980 PSMC3	5	PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [cytosol] (R-HSA-68774)	0.669	4
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.643	4
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.589	2
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.564	2
UniProt:P60900 PSMA6	2	PSMA6 [nucleoplasm] (R-HSA-174314) PSMA6 [cytosol] (R-HSA-68734)	0.564	2
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.564	2
UniProt:P48556 PSMD8	2	PSMD8 [nucleoplasm] (R-HSA-174318) PSMD8 [cytosol] (R-HSA-68808)	0.564	3
UniProt:P49720 PSMB3	2	PSMB3 [nucleoplasm] (R-HSA-174341) PSMB3 [cytosol] (R-HSA-68747)	0.527	3
UniProt:P49721 PSMB2	2	PSMB2 [nucleoplasm] (R-HSA-174335) PSMB2 [cytosol] (R-HSA-68744)	0.527	2
UniProt:Q16186 ADRM1	2	ADRM1 [nucleoplasm] (R-HSA-9918361) ADRM1 [cytosol] (R-HSA-5665939)	0.527	4
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	5
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.527	3
UniProt:Q9BRP4 PAAF1	1	PAAF1 [cytosol] (R-HSA-9907973)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	11