Reactome | PSMD3 [nucleoplasm]

PSMD3 [nucleoplasm]

Stable Identifier

R-HSA-174328

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S proteasome non-ATPase regulatory subunit 3, 26S proteasome regulatory subunit S3, Proteasome subunit p58

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD3 [nucleoplasm] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD3 [nucleoplasm] (Homo sapiens)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
        
        Degradation of multiubiquitinated Cdh1 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD3 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD3 [nucleoplasm] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD3 [nucleoplasm] (Homo sapiens)

DNA Replication (Homo sapiens)

- DNA Replication Pre-Initiation (Homo sapiens)
  - Assembly of the pre-replicative complex (Homo sapiens)
    - Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD3 [nucleoplasm] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Gastrulation (Homo sapiens)
  - Formation of paraxial mesoderm (Homo sapiens)
    - Somitogenesis (Homo sapiens)
      - RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD3 [nucleoplasm] (Homo sapiens)
        
        TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD3 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - Regulation of RUNX2 expression and activity (Homo sapiens)
        
        26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD3 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX3 (Homo sapiens)
      - Regulation of RUNX3 expression and activity (Homo sapiens)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD3 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Hedgehog (Homo sapiens)
  - Hedgehog 'on' state (Homo sapiens)
    - GLI2,3 are degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD3 [nucleoplasm] (Homo sapiens)
- Signaling by NOTCH (Homo sapiens)
  - Signaling by NOTCH4 (Homo sapiens)
    - Negative regulation of NOTCH4 signaling (Homo sapiens)
      - Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43242 PSMD3

Gene Names

PSMD3

Chain

chain:1-534

Reference Genes

BioGPS Gene:5709 PSMD3

COSMIC (genes):PSMD3 PSMD3

CTD Gene:5709 PSMD3

dbSNP Gene:5709 PSMD3

ENSEMBL:ENSG00000108344 PSMD3

HGNC:9560 PSMD3

KEGG:hsa:5709 PSMD3

Monarch:5709 PSMD3

NCBI Gene:5709 PSMD3

OMIM:617676 PSMD3

UCSC:O43242 PSMD3

Reference Transcript

RefSeq:NM_002809.3 PSMD3

Other Identifiers

11715515_a_at

11715516_x_at

11749048_a_at

11761159_at

16833934

17117724

201388_PM_at

201388_at

3720637

3720638

3720639

3720640

3720646

3720647

3720649

3720650

3720651

3720652

3720653

3720654

3720655

3720658

3720659

3720660

3720662

3720663

3720664

3720665

3720666

3720667

3720668

3720669

3720670

3720672

3720673

3720674

39155_at

5709

8006984

ADDON000377.hg

ADDON001979.hg

A_14_P101491

A_21_P0014810

A_23_P26783

A_24_P289726

GE81195

GO:0000502

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005829

GO:0005838

GO:0006511

GO:0008541

GO:0016020

GO:0022624

GO:0030163

GO:0030234

GO:0032991

GO:0034774

GO:0042176

GO:0043161

GO:0043226

GO:0070062

GO:0098772

GO:1904813

HMNXSV003001923

HMNXSV003054365

ILMN_1796430

PH_hs_0001007

TC17000485.hg

g4506228_3p_s_at

p25073

Participates

as a component of

19S RP lid particle 3 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMD3 [cytosol]

PSMD3 [secretory granule lumen]

PSMD3 [extracellular region]

PSMD3 [ficolin-1-rich granule lumen]

Inferred To

PSMD3 [nucleoplasm] (Bos taurus)

PSMD3 [nucleoplasm] (Canis familiaris)

PSMD3 [nucleoplasm] (Gallus gallus)

PSMD3 [nucleoplasm] (Sus scrofa)

psmd3 [nucleoplasm] (Danio rerio)

psmd3 [nucleoplasm] (Xenopus tropicalis)

Rpn3 [nucleoplasm] (Drosophila melanogaster)

rpn-3 [nucleoplasm] (Caenorhabditis elegans)

Psmd3 [nucleoplasm] (Mus musculus)

Psmd3 [nucleoplasm] (Rattus norvegicus)

psmD3 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002800.2

OpenTargets

ENSG00000108344

ENSEMBL

ENST00000264639, ENSP00000264639

HPA

ENSG00000108344-PSMD3

PRO

O43242

Pharos - Targets

O43242

GlyGen

O43242

PDB

5VFU, 5VFT, 5VHF, 6MSJ, 7W3B, 5T0J, 7W3J, 7W3H, 5VFR, 5LN3, 7W3A, 6MSB, 5T0G, 5M32, 7W39, 5VGZ, 7W3C, 7QYB, 7QY7, 6MSD, 7QXX, 5VHS, 5GJR, 7W3F, 5VHH, 6WJD, 5VFS, 5VFP, 6MSK, 5T0I, 5VFQ, 5L4K, 7W38, 6MSH, 7W3I, 7QXU, 5T0H, 7W3G, 7QXW, 6WJN, 6MSG, 7W37, 5VHI, 7QXP, 7QXN, 5T0C, 8CVT, 6MSE, 7W3K, 7W3M, 7QYA, 5GJQ

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.788	6
UniProt:O43298 ZBT43			0.781	7
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.725	7
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406)	0.725	5
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435)	0.669	4
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440)	0.669	5
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.669	5
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413)	0.669	5
UniProt:Q9BRP4 PAAF1	1	PAAF1 [cytosol] (R-HSA-9907973)	0.669	4
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.669	5
UniProt:P60896 SEM1	2	SEM1 [cytosol] (R-HSA-8866674) SEM1 [nucleoplasm] (R-HSA-8866665)	0.666	4
UniProt:P60900 PSMA6	2	PSMA6 [cytosol] (R-HSA-68734) PSMA6 [nucleoplasm] (R-HSA-174314)	0.666	4
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436)	0.648	4
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.648	4
UniProt:O00487 PSMD14	5	PSMD14 [cytosol] (R-HSA-68722) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419)	0.643	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.643	6
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.643	4
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.643	3
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.643	4
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.643	4
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416)	0.643	5
UniProt:P25963 NFKBIA	9	NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) PolyUb-NFKBIA [cytosol] (R-HSA-6782960)	0.556	3
UniProt:O43395 PRPF3	1	PRPF3 [nucleoplasm] (R-HSA-6806806)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9C0F1 CEP44			0.556	3
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285)	0.527	3
UniProt:P54578 USP14	1	USP14 [cytosol] (R-HSA-5689541)	0.527	2
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.527	2
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	4
UniProt:Q53HC0 CCD92			0.527	3
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429)	0.527	3
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.527	4
UniProt:O00233 PSMD9	1	PSMD9 [cytosol] (R-HSA-68810)	0.527	2
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.527	2
UniProt:P16885 PLCG2	8	p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12

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