Reactome | PSMD3 [nucleoplasm]

PSMD3 [nucleoplasm]

Stable Identifier

R-HSA-174328

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S proteasome non-ATPase regulatory subunit 3, 26S proteasome regulatory subunit S3, Proteasome subunit p58

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMD3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43242 PSMD3

Gene Names

PSMD3

Chain

chain:1-534

Reference Genes

BioGPS Gene:5709 PSMD3

COSMIC (genes):PSMD3 PSMD3

CTD Gene:5709 PSMD3

dbSNP Gene:5709 PSMD3

ENSEMBL:ENSG00000108344 PSMD3

ENSEMBL:ENSG00000108344.15 PSMD3

HGNC:9560 PSMD3

KEGG Gene (Homo sapiens):5709 PSMD3

Monarch:5709 PSMD3

NCBI Gene:5709 PSMD3

OMIM:617676 PSMD3

UCSC:O43242 PSMD3

Reference Transcript

RefSeq:NM_002809.3 PSMD3

Other Identifiers

11715515_a_at

11715516_x_at

11749048_a_at

16833934

201388_PM_at

201388_at

3720637

3720638

3720639

3720640

3720646

3720647

3720649

3720650

3720651

3720653

3720659

3720660

3720662

3720663

3720665

3720670

3720672

3720673

3720674

39155_at

5709

8006984

A_23_P26783

A_24_P289726

GE81195

GO:0000502

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005829

GO:0005838

GO:0006511

GO:0008541

GO:0016020

GO:0022624

GO:0030163

GO:0030234

GO:0031410

GO:0032991

GO:0034774

GO:0042176

GO:0043161

GO:0043226

GO:0070062

GO:0098772

GO:1904813

HMNXSV003001923

ILMN_1796430

PH_hs_0001007

TC17000485.hg

g4506228_3p_s_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMD3 [secretory granule lumen]

PSMD3 [extracellular region]

PSMD3 [ficolin-1-rich granule lumen]

PSMD3 [cytosol]

Inferred To

PSMD3 [nucleoplasm] (Bos taurus)

PSMD3 [nucleoplasm] (Canis familiaris)

PSMD3 [nucleoplasm] (Gallus gallus)

PSMD3 [nucleoplasm] (Sus scrofa)

psmd3 [nucleoplasm] (Xenopus tropicalis)

Rpn3 [nucleoplasm] (Drosophila melanogaster)

rpn-3 [nucleoplasm] (Caenorhabditis elegans)

zgc:65867 [nucleoplasm] (Danio rerio)

Psmd3 [nucleoplasm] (Mus musculus)

Psmd3 [nucleoplasm] (Rattus norvegicus)

psmD3 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002800.2

OpenTargets

ENSG00000108344

GeneCards

O43242

HPA

ENSG00000108344-PSMD3

Ensembl

ENST00000264639, ENSG00000108344, ENSP00000264639

PRO

O43242

Pharos - Targets

O43242

PDB

6MSG, 7W3H, 6WJD, 7W3I, 7W3G, 7W3F, 7W3C, 7W3B, 7QXW, 7W3A, 7QXU, 5VHS, 7QXP, 5T0I, 5VHI, 5T0H, 5VHH, 8CVT, 5T0J, 5LN3, 5M32, 5VHF, 5T0G, 6MSE, 7W3M, 5T0C, 7W3K, 6MSB, 5L4K, 7W3J, 6MSD, 5VGZ, 7QYB, 7QYA, 5GJQ, 7QY7, 7QXX, 5GJR, 7W39, 5VFU, 7W37, 7W38, 5VFS, 5VFR, 7QXN, 5VFT, 5VFP, 6WJN, 6MSH, 6MSK, 5VFQ, 6MSJ

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.669	4
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.564	2
UniProt:P25963 NFKBIA	11	PolyUb-NFKBIA [cytosol] (R-HSA-6782960) NFKBIA M37K [cytosol] (R-HSA-5228805) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol] (R-HSA-5607659) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-9711050) NFKBIA S32I [cytosol] (R-HSA-5228846)	0.556	3
UniProt:P60896 SEM1	2	SEM1 [nucleoplasm] (R-HSA-8866665) SEM1 [cytosol] (R-HSA-8866674)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	3
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.527	3
UniProt:P16885 PLCG2	8	p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.508	2