Reactome | PSMD4 [nucleoplasm]

PSMD4 [nucleoplasm]

Stable Identifier

R-HSA-174330

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S proteasome non-ATPase regulatory subunit 4, 26S proteasome regulatory subunit S5A, Rpn10, Multiubiquitin chain binding protein, Antisecretory factor-1, AF, ASF

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMD4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P55036 PSMD4

Gene Names

PSMD4, MCB1

Chain

chain:1-377

Reference Genes

BioGPS Gene:5710 PSMD4

COSMIC (genes):PSMD4 PSMD4

CTD Gene:5710 PSMD4

dbSNP Gene:5710 PSMD4

ENSEMBL:ENSG00000159352 PSMD4

ENSEMBL:ENSG00000159352.16 PSMD4

HGNC:9561 PSMD4

KEGG Gene (Homo sapiens):5710 PSMD4

Monarch:5710 PSMD4

NCBI Gene:5710 PSMD4

OMIM:601648 PSMD4

UCSC:P55036 PSMD4

Reference Transcript

RefSeq:NM_002810.2 PSMD4

Other Identifiers

11757699_x_at

200882_3p_s_at

200882_PM_s_at

200882_s_at

210460_PM_s_at

210460_s_at

211609_PM_x_at

211609_x_at

2358822

2358826

2358827

2358832

2358833

2358835

2358837

2358838

2358842

2358844

2358849

2358850

3300871

3300872

3300876

3300877

3930994

3930995

39749_at

5710

7905374

A_23_P12168

GE554910

GE61019

GO:0000502

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006511

GO:0008540

GO:0022624

GO:0030163

GO:0031593

GO:0042802

GO:0043161

GO:0043226

GO:0060090

HMNXSV003019851

HMNXSV003055643

ILMN_1728355

ILMN_2344130

TC01001205.hg

U24704_at

g5292160_3p_at

g8918352_3p_s_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMD4 [cytosol]

Inferred To

psmD4 [nucleoplasm] (Dictyostelium discoideum)

Psmd4 [nucleoplasm] (Mus musculus)

Psmd4 [nucleoplasm] (Rattus norvegicus)

rpn-10 [nucleoplasm] (Caenorhabditis elegans)

PSMD4 [nucleoplasm] (Bos taurus)

PSMD4 [nucleoplasm] (Canis familiaris)

PSMD4 [nucleoplasm] (Gallus gallus)

PSMD4 [nucleoplasm] (Sus scrofa)

psmd4 [nucleoplasm] (Xenopus tropicalis)

zgc:86833 [nucleoplasm] (Danio rerio)

Rpn10 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_002801.1

OpenTargets

ENSG00000159352

GeneCards

P55036

HPA

ENSG00000159352-PSMD4

Ensembl

ENST00000368884, ENSP00000357879, ENSG00000159352

PRO

P55036

Pharos - Targets

P55036

PDB

2KDF, 6MSE, 5L4K, 5VFQ, 7W3I, 5T0J, 7W3H, 6MSD, 5VHH, 7W38, 7W37, 6MSB, 5VHF, 5T0I, 5T0H, 5GJR, 7W3C, 6WJD, 8CVT, 5VFS, 7W3B, 5M32, 7W3M, 1P9D, 5LN3, 6MSJ, 6MSH, 7W3A, 7W3K, 5VHS, 1P9C, 7W3J, 5VFR, 5VHI, 7QYB, 7QYA, 7W39, 6U19, 6MSG, 7QXN, 1YX6, 5VFU, 5VFP, 7W3G, 1YX5, 6WJN, 7W3F, 1YX4, 7QY7, 5VFT, 6MUN, 2KDE, 7QXX, 5T0C, 7QXW, 6MSK, 5VGZ, 5T0G, 1UEL, 7QXU, 5GJQ, 7QXP

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.851	7
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.77	5
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.669	5
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.553	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.519	7
UniProt:P24610	1	Pax3 [nucleoplasm] (R-MMU-5603237)	0.499	3
UniProt:P41134 ID1	1	ID1 [nucleoplasm] (R-HSA-2534101)	0.463	2

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